Evaluation of Stereotactic Radiotherapy of the Resection Cavity After Surgery of Brain Metastases Compared to Postoperative Whole-Brain Radiotherapy (ESTRON)-A Single-Center Prospective Randomized Trial
2018 | journal article
Jump to: Cite & Linked | Documents & Media | Details | Version history
Cite this publication
Evaluation of Stereotactic Radiotherapy of the Resection Cavity After Surgery of Brain Metastases Compared to Postoperative Whole-Brain Radiotherapy (ESTRON)-A Single-Center Prospective Randomized Trial
El Shafie, R. A. ; Paul, A.; Bernhardt, D.; Hauswald, H.; Welzel, T.; Sprave, T. & Hommertgen, A. et al. (2018)
Neurosurgery, 83(3) pp. 566-573. DOI: https://doi.org/10.1093/neuros/nyy021
Documents & Media
Details
- Authors
- El Shafie, Rami A. ; Paul, Angela; Bernhardt, Denise; Hauswald, Henrik; Welzel, Thomas; Sprave, Tanja; Hommertgen, Adriane; Krisam, Johannes; Schmitt, Daniela; Klüter, Sebastian; Schubert, Kai; Klose, Christina; Kieser, Meinhard; Debus, Jürgen; Rieken, Stefan
- Abstract
- Neurosurgical resection is recommended for symptomatic brain metastases, in oligometastatic patients or for histology acquisition. Without adjuvant radiotherapy, roughly two-thirds of the patients relapse at the resection site within 24 mo, while the risk of new metastases in the untreated brain is around 50%. Adjuvant whole-brain radiotherapy (WBRT) can reduce the risk of both scenarios of recurrence significantly, although the associated neurocognitive toxicity is substantial, while stereotactic radiotherapy (SRT) improves local control at comparably low toxicity.
- Issue Date
- 2018
- Journal
- Neurosurgery
- ISSN
- 0148-396X
- eISSN
- 1524-4040
- Language
- English
