Metformin Enhanced in Vitro Radiosensitivity Associates with G2/M Cell Cycle Arrest and Elevated Adenosine-5'-monophosphate-activated Protein Kinase Levels in Glioblastoma
2017-12 | journal article
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Metformin Enhanced in Vitro Radiosensitivity Associates with G2/M Cell Cycle Arrest and Elevated Adenosine-5'-monophosphate-activated Protein Kinase Levels in Glioblastoma
Adeberg, S.; Bernhardt, D.; Harrabi, S. B; Nicolay, N. H; Hörner-Rieber, J.; König, L. & Repka, M. et al. (2017)
Radiology and Oncology, 51(4) pp. 431-437. DOI: https://doi.org/10.1515/raon-2017-0042
Documents & Media
Details
- Authors
- Adeberg, Sebastian; Bernhardt, Denise; Harrabi, Semi B; Nicolay, Nils H; Hörner-Rieber, Juliane; König, Laila; Repka, Michael; Mohr, Angela; Abdollahi, Amir; Weber, Klaus-Josef; Debus, Juergen; Rieken, Stefan
- Abstract
- It is hypothesized that metabolism plays a strong role in cancer cell regulation. We have recently demonstrated improved progression-free survival in patients with glioblastoma who received metformin as an antidiabetic substance during chemoradiation. Although metformin is well-established in clinical use the influence of metformin in glioblastoma is far from being understood especially in combination with other treatment modalities such as radiation and temozolomide.
- Issue Date
- December-2017
- Journal
- Radiology and Oncology
- ISSN
- 1318-2099
- Language
- English
