O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation is a rare event in soft tissue sarcoma

2012-10-30 | journal article; research paper

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​O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation is a rare event in soft tissue sarcoma​
Jakob, J. ; Hille, M.; Sauer, C.; Ströbel, P.; Wenz, F. & Hohenberger, P.​ (2012) 
Radiation Oncology, 7(1) pp. 180​.​ DOI: https://doi.org/10.1186/1748-717X-7-180 

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Authors
Jakob, Jens ; Hille, Maren; Sauer, Christian; Ströbel, Philipp; Wenz, Frederik; Hohenberger, Peter
Abstract
Gene silencing of O6-methylguanine-DNA methyltransferase (MGMT) by promoter methylation improves the outcome of glioblastoma patients after combined therapy of alkylating chemotherapeutic agents and radiation. The purpose of this study was to assess the frequency of MGMT promoter methylation in soft tissue sarcoma to identify patients eligible for alkylating agent chemotherapy such as temozolomide.
Issue Date
30-October-2012
Journal
Radiation Oncology 
ISSN
1748-717X
Language
English

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