Glycopeptides by Linch‐Pin C−H Activations for Peptide‐Carbohydrate Conjugation by Manganese(I)‐Catalysis
2019 | journal article. A publication with affiliation to the University of Göttingen.
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Glycopeptides by Linch‐Pin C−H Activations for Peptide‐Carbohydrate Conjugation by Manganese(I)‐Catalysis
Wang, W.; Subramanian, P.; Martinazzoli, O.; Wu, J. & Ackermann, L. (2019)
Chemistry – A European Journal, 25(45) pp. 10585-10589. DOI: https://doi.org/10.1002/chem.201902788
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Details
- Authors
- Wang, Wei; Subramanian, Parthasarathi; Martinazzoli, Oscar; Wu, Jun; Ackermann, Lutz
- Abstract
- Abstract Late‐stage C−H glycosylations of structurally complex amino acids and peptides were accomplished by means of racemization‐free manganese(I)‐catalyzed C−H activation. Thus, glycosylative modifications proved to be viable by a linch‐pin approach, featuring chemo‐ and site‐selective C−H transformations. The peptide–saccharide conjugation provided modular access to structurally complex glycopeptides, likewise enabling the assembly of fluorescent‐labelled glycopeptides.
- Issue Date
- 2019
- Journal
- Chemistry – A European Journal
- ISSN
- 0947-6539
- eISSN
- 1521-3765
- ISSN
- 0947-6539
- eISSN
- 1521-3765
- Language
- English
- Sponsor
- Deutsche Forschungsgemeinschaft https://doi.org/10.13039/501100001659
China Scholarship Council https://doi.org/10.13039/501100004543
