Effects of cerebrovascular challenges on plasma endothelin
2002 | journal article
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- Authors
- Jordan, Wolfgang ; Deckers, Markus ; Kamrowski, H. ; Brunner, Edgar ; Ehrenreich, Hannelore ; Hajak, G.
- Abstract
- Plasma endothelin elevations have been associated with cerebrovascular pathology. Mechanisms of stimulation, however, are unknown. Therefore, in healthy subjects a marked physiological cerebrovascular response was experimentally provoked by hypercapnia, hypocapnia, and alternating capneic conditions. During these challenges plasma immunoreactive- endothelin-1 (ir-ET-1) concentrations were determined using a radioimmunassay. Physiological effects were continuously recorded for pCO(2), cerebral blood flow velocity, pulse frequency, and arterial blood pressure. No alterations in plasma ET-1 levels were found upon any of the cerebrovascular stimuli. We conclude that massive cerebrovascular challenges in healthy individuals do not lead to high circulating ET-I levels. (C) 2002 Elsevier Science Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
- Issue Date
- 2002
- Journal
- Neuroscience Research
- ISSN
- 0168-0102
- Language
- English