Acute and chronic effects of noradrenergic enhancement on transcranial direct current stimulation-induced neuroplasticity in humans
2017 | journal article. A publication with affiliation to the University of Göttingen.
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Acute and chronic effects of noradrenergic enhancement on transcranial direct current stimulation-induced neuroplasticity in humans
Kuo, H.-I. ; Paulus, W. ; Batsikadze, G. ; Jamil, A. ; Kuo, M.-F. & Nitsche, M. A. (2017)
The Journal of Physiology, 595(4) pp. 1305-1314. DOI: https://doi.org/10.1113/JP273137
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Details
- Title Variant(s)
- Long-term impact of noradrenaline on neuroplasticity
- Authors
- Kuo, Hsiao-I. ; Paulus, Walter ; Batsikadze, Giorgi ; Jamil, Asif ; Kuo, Min-Fang ; Nitsche, Michael A.
- Abstract
- Chronic administration of the selective noradrenaline reuptake inhibitor (NRI) reboxetine (RBX) increased and prolonged the long-term potentiation-like plasticity induced by anodal transcranial direct current stimulation (tDCS) for over 24 h. Chronic administration of RBX converted cathodal tDCS-induced long-term depression-like plasticity into facilitation for 120 min. Chronic noradrenergic activity enhancement on plasticity of the human brain might partially explain the delayed therapeutic impact of selective NRIs in depression and other neuropsychiatric diseases.
- Issue Date
- 2017
- Journal
- The Journal of Physiology
- ISSN
- 0022-3751
- ISSN
- 1469-7793
- Language
- English
