Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis

2019 | journal article. A publication with affiliation to the University of Göttingen.

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​Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis​
Zhu, Y.; Wei, Y.; Zhang, R.; Dong, X.; Shen, S.; Zhao, Y. & Bai, J. et al.​ (2019) 
Cancer Epidemiology, Biomarkers & Prevention28(5) pp. 935​-942​.​ DOI: https://doi.org/10.1158/1055-9965.EPI-18-0356 

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Authors
Zhu, Ying; Wei, Yongyue; Zhang, Ruyang; Dong, Xuesi; Shen, Sipeng; Zhao, Yang; Bai, Jianling; Albanes, Demetrius; Caporaso, Neil E.; Landi, Maria Teresa; Zhu, Bin; Chanock, Stephen J.; Gu, Fangyi; Lam, Stephen; Tsao, Ming-Sound; Shepherd, Frances A.; Tardon, Adonina; Fernández-Somoano, Ana; Fernandez-Tardon, Guillermo; Chen, Chu; Barnett, Matthew J.; Doherty, Jennifer; Bojesen, Stig E.; Johansson, Mattias; Brennan, Paul; McKay, James D.; Carreras-Torres, Robert; Muley, Thomas; Risch, Angela; Wichmann, Heunz-Erich; Bickeboeller, Heike ; Rosenberger, Albert ; Rennert, Gad; Saliba, Walid; Arnold, Susanne M.; Field, John K.; Davies, Michael P.A.; Marcus, Michael W.; Wu, Xifeng; Ye, Yuanqing; Le Marchand, Loic; Wilkens, Lynne R.; Melander, Olle; Manjer, Jonas; Brunnström, Hans; Hung, Rayjean J.; Liu, Geoffrey; Brhane, Yonathan; Kachuri, Linda; Andrew, Angeline S.; Duell, Eric J.; Kiemeney, Lambertus A.; van der Heijden, Erik HFM; Haugen, Aage; Zienolddiny, Shanbeh; Skaug, Vidar; Grankvist, Kjell; Johansson, Mikael; Woll, Penella J.; Cox, Angela; Taylor, Fiona; Teare, Dawn M.; Lazarus, Philip; Schabath, Matthew B.; Aldrich, Melinda C.; Houlston, Richard S.; McLaughlin, John; Stevens, Victoria L.; Shen, Hongbing; Hu, Zhibin; Dai, Juncheng; Amos, Christopher I.; Han, Younghun; Zhu, Dakai; Goodman, Gary E.; Chen, Feng; Christiani, David C.
Abstract
Platelets are a critical element in coagulation and inflammation, and activated platelets are linked to cancer risk through diverse mechanisms. However, a causal relationship between platelets and risk of lung cancer remains unclear.
Issue Date
2019
Journal
Cancer Epidemiology, Biomarkers & Prevention 
ISSN
1055-9965
eISSN
1538-7755
ISSN
1055-9965; 1538-7755
eISSN
1538-7755
Language
English

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