Impact of Plasma Kynurenine Level on Functional Capacity and Outcome in Heart Failure. - Results From Studies Investigating Co-morbidities Aggravating Heart Failure (SICA-HF)
2017 | journal article. A publication with affiliation to the University of Göttingen.
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Impact of Plasma Kynurenine Level on Functional Capacity and Outcome in Heart Failure. - Results From Studies Investigating Co-morbidities Aggravating Heart Failure (SICA-HF)
Konishi, M.; Ebner, N. ; Springer, J. ; Schefold, J. C.; Doehner, W.; Dschietzig, T. B. & Anker, S. D. et al. (2017)
Circulation Journal, 81(1) pp. 52-61. DOI: https://doi.org/10.1253/circj.CJ-16-0791
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Details
- Authors
- Konishi, Masaaki; Ebner, Nicole ; Springer, Jochen ; Schefold, Joerg C.; Doehner, Wolfram; Dschietzig, Thomas Bernd; Anker, Stefan D. ; von Haehling, Stephan
- Abstract
- Background: Kynurenine is a circulating metabolite from the essential amino acid tryptophan. Accelerated degradation of kynurenine in skeletal muscle has been reported to provide an anti-inflammatory effect. The aim of this study was to investigate the association between blood kynurenine and muscle mass/function in patients with heart failure (HF), in whom diseased muscle mass/function plays a pathophysiological role. Methods and Results: Plasma kynurenine was assessed in 249 patients with HF (67 +/- 11 years, 21% women) and in 45 controls from the SICA-HF study. Kynurenine was higher in 173 HF patients with reduced ejection fraction (EF) and in 76 patients with preserved EF than controls (3.5 +/- 1.5, 3.4 +/- 1.3, and 2.4 +/- 1.1 mu mol/L, P<0.001). In HF patients, kynurenine had an inverse association with handgrip strength (r=-0.26, P<0.01), peak oxygen consumption (r=-0.29, P<0.01), 6-min walk distance (r=-0.23, P<0.01), and had a positive association with kidney and liver function parameters. No correlation was observed between kynurenine and lean mass. On multivariable linear regression analysis, a significant association was noted between kynurenine and peak oxygen consumption even after adjustment for age, gender, BMI, and hemoglobin (beta-0.23, P<0.001). Patients with higher kynurenine were at higher risk of death (adjusted HR, 1.46 per 1 mu mol/L, P<0.01). Conclusions: In stable HF patients, plasma kynurenine was inversely correlated with muscle strength and functional capacity as well as with liver and kidney function.
- Issue Date
- 2017
- Status
- published
- Publisher
- Japanese Circulation Soc
- Journal
- Circulation Journal
- ISSN
- 1346-9843
- eISSN
- 1347-4820
- ISSN
- 1347-4820; 1346-9843
- Language
- English