Automated cerebrospinal fluid cytology
2008 | journal article; research paper. A publication with affiliation to the University of Göttingen.
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- Authors
- Heller, T.; Nagel, I.; Ehrlich, B.; Bähr, M. ; Strik, H.
- Abstract
- OBJECTIVE: To evaluate the Abbott CELL-DYN Sapphire cytometer for cerebrospinal fluid (CSF) cell count and differentiation. METHODS: One hundred three analyses of CSF cells by the CELL-DYN Sapphire were compared with routine cell count and microscopic differentiation and correlation coefficients calculated. RESULTS: The total cell count of both methods correlated well. The detection of erythrocytes was good (0.898), and a higher content of erythrocytes > 100/mu L had little effect on total leukocyte count. The correlation between both methods was best with higher leukocyte counts > 25/mu L (r = 0.987), whereas at cell counts < 25/mu L, the correlation was considerably less precise (r = 0.613). For the differentiation of cells, lymphocytes and neutrophils showed moderate correlation. The results for monocytes and eosinophils did not correlate. CONCLUSION: The results for the total cell count in this study are comparable with those achieved with the Bayer Advia 120. While the Abbott CELL-DYN Sapphire yielded slightly better results for erythrocytes and total cell count with a higher erythrocyte content, the Advia 120 achieved slightly better results of lymphocyte and neutrophil count in a previous study.
- Issue Date
- 2008
- Journal
- Analytical and quantitative cytology and histology
- ISSN
- 0884-6812
- Language
- English