Cerebral proton magnetic resonance spectroscopy of a patient with giant axonal neuropathy
2003 | journal article. A publication with affiliation to the University of Göttingen.
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Cerebral proton magnetic resonance spectroscopy of a patient with giant axonal neuropathy
Brockmann, K.; Pouwels, P. J.; Dechent, P.; Flanigan, K. M.; Frahm, J. & Hanefeld, F. (2003)
Brain and Development, 25(1) pp. 45-50. DOI: https://doi.org/10.1016/s0387-7604(02)00154-7
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Details
- Authors
- Brockmann, Knut; Pouwels, Petra J.W.; Dechent, Peter; Flanigan, Kevin M.; Frahm, Jens; Hanefeld, Folker
- Abstract
- Magnetic resonance imaging of a girl with giant axonal neuropathy revealed a progressive white matter disease. In close agreement with histopathological features reported previously, localized proton magnetic resonance spectroscopy at 9 and 12 years of age indicated a specific damage or loss of axons (reduced N-acetylaspartate and N-acetylaspartylglutamate) accompanied by acute demyelination (elevated choline-containing compounds, myo-inositol, and lactate) in white matter as well as a generalized proliferation of glial cells (elevated choline-containing compounds and myo-inositol) in both gray and white matter. (C) 2002 Elsevier Science B.V. All rights reserved.
- Issue Date
- 2003
- Journal
- Brain and Development
- ISSN
- 0387-7604
- Language
- English
