The Human Brain Is Best Described as Being on a Female/Male Continuum: Evidence from a Neuroimaging Connectivity Study
2021 | journal article. A publication with affiliation to the University of Göttingen.
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The Human Brain Is Best Described as Being on a Female/Male Continuum: Evidence from a Neuroimaging Connectivity Study
Zhang, Y.; Luo, Q.; Huang, C.-C.; Lo, C. Lo, Chun-Yi Zac; Langley, C.; Desrivières, S. & Quinlan, E. B. et al. (2021)
Cerebral Cortex, 31(6) pp. 3021-3033. DOI: https://doi.org/10.1093/cercor/bhaa408
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Details
- Authors Group
- for the IMAGEN consortium
The authors list is uncomplete: - Authors
- Zhang, Yi; Luo, Qiang; Huang, Chu-Chung; Lo, Chun-Yi Zac; Langley, Christelle; Desrivières, Sylvane; Quinlan, Erin Burke; Banaschewski, Tobias ; Millenet, Sabina; Feng, Jianfeng
- Abstract
- Abstract Psychological androgyny has long been associated with greater cognitive flexibility, adaptive behavior, and better mental health, but whether a similar concept can be defined using neural features remains unknown. Using the neuroimaging data from 9620 participants, we found that global functional connectivity was stronger in the male brain before middle age but became weaker after that, when compared with the female brain, after systematic testing of potentially confounding effects. We defined a brain gender continuum by estimating the likelihood of an observed functional connectivity matrix to represent a male brain. We found that participants mapped at the center of this continuum had fewer internalizing symptoms compared with those at the 2 extreme ends. These findings suggest a novel hypothesis proposing that there exists a neuroimaging concept of androgyny using the brain gender continuum, which may be associated with better mental health in a similar way to psychological androgyny.
Abstract Psychological androgyny has long been associated with greater cognitive flexibility, adaptive behavior, and better mental health, but whether a similar concept can be defined using neural features remains unknown. Using the neuroimaging data from 9620 participants, we found that global functional connectivity was stronger in the male brain before middle age but became weaker after that, when compared with the female brain, after systematic testing of potentially confounding effects. We defined a brain gender continuum by estimating the likelihood of an observed functional connectivity matrix to represent a male brain. We found that participants mapped at the center of this continuum had fewer internalizing symptoms compared with those at the 2 extreme ends. These findings suggest a novel hypothesis proposing that there exists a neuroimaging concept of androgyny using the brain gender continuum, which may be associated with better mental health in a similar way to psychological androgyny. - Issue Date
- 2021
- Journal
- Cerebral Cortex
- ISSN
- 1047-3211
- eISSN
- 1460-2199
- Language
- English