Reference point insensitive molecular data analysis
2017 | journal article; research paper
Jump to: Cite & Linked | Documents & Media | Details | Version history
Documents & Media
Details
- Authors
- Altenbuchinger, Michael ; Rehberg, T.; Zacharias, H. U.; Stämmler, F.; Dettmer, K.; Weber, D.; Hiergeist, A.; Gessner, A.; Holler, E.; Oefner, P. J.; Spang, R.
- Abstract
- In biomedicine, every molecular measurement is relative to a reference point, like a fixed aliquot of RNA extracted from a tissue, a defined number of blood cells, or a defined volume of biofluid. Reference points are often chosen for practical reasons. For example, we might want to assess the metabolome of a diseased organ but can only measure metabolites in blood or urine. In this case, the observable data only indirectly reflects the disease state. The statistical implications of these discrepancies in reference points have not yet been discussed.
- Issue Date
- 2017
- Journal
- Bioinformatics
- ISSN
- 1367-4803; 1460-2059
- eISSN
- 1367-4811
- Language
- English