Satb2 determines miRNA expression and long-term memory in the adult central nervous system
2016 | journal article. A publication with affiliation to the University of Göttingen.
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Satb2 determines miRNA expression and long-term memory in the adult central nervous system
Jaitner, C.; Reddy, C.; Abentung, A.; Whittle, N.; Rieder, D.; Delekate, A. & Korte, M. et al. (2016)
eLife, 5 art. e1736. DOI: https://doi.org/10.7554/eLife.17361
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Details
- Authors
- Jaitner, Clemens; Reddy, Chethan; Abentung, Andreas; Whittle, Nigel; Rieder, Dietmar; Delekate, Andrea; Korte, Martin; Jain, Gaurav; Fischer, Andre; Sananbenesi, Farahnaz; Cera, Isabella; Singewald, Nicolas; Dechant, Georg; Apostolova, Galina
- Abstract
- SATB2 is a risk locus for schizophrenia and encodes a DNA-binding protein that regulates higher-order chromatin configuration. In the adult brain Satb2 is almost exclusively expressed in pyramidal neurons of two brain regions important for memory formation, the cerebral cortex and the CA1-hippocampal field. Here we show that Satb2 is required for key hippocampal functions since deletion of Satb2 from the adult mouse forebrain prevents the stabilization of synaptic long-term potentiation and markedly impairs long-term fear and object discrimination memory. At the molecular level, we find that synaptic activity and BDNF up-regulate Satb2, which itself binds to the promoters of coding and non-coding genes. Satb2 controls the hippocampal levels of a large cohort of miRNAs, many of which are implicated in synaptic plasticity and memory formation. Together, our findings demonstrate that Satb2 is critically involved in long-term plasticity processes in the adult forebrain that underlie the consolidation and stabilization of context-linked memory.
- Issue Date
- 2016
- Journal
- eLife
- Organization
- Universitätsmedizin Göttingen
- ISSN
- 2050-084X
- Language
- English