Benefit of postoperative radiotherapy for early tumors with single ipsilateral lymph node metastasis
2019 | journal article. A publication with affiliation to the University of Göttingen.
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Benefit of postoperative radiotherapy for early tumors with single ipsilateral lymph node metastasis
Weiss, B. G.; Anczykowski, M. Z.; Flach, S.; Spiegel, J. L.; Kitz, J.; Bertlich, M. & Canis, M. et al. (2019)
The Laryngoscope, 130(10) pp. 1-9. DOI: https://doi.org/10.1002/lary.28394
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Details
- Authors
- Weiss, Bernhard G.; Anczykowski, Mahalia Z.; Flach, Susanne; Spiegel, Jennifer L.; Kitz, Julia; Bertlich, Mattis; Canis, Martin; Jakob, Mark; Ihler, Friedrich
- Abstract
- OBJECTIVES/HYPOTHESIS: Indication for postoperative radiotherapy in patients with locally circumscribed tumors (pT1-pT2) and a single ipsilateral lymph node metastasis (pN1) is debatable. The aim of this study was to evaluate the oncological long-term outcome of patients with pT1-pT2 pN1 squamous cell carcinoma (SCC) of the oral cavity, the oropharynx, and the hypopharynx without extracapsular spread (ECS) after a margin-negative surgical resection, who either received or did not receive postoperative (chemo)radiotherapy. STUDY DESIGN: Retrospective case series. METHODS: The oncological outcome of patients with pT1-pT2 pN1 SCC without ECS was evaluated retrospectively. All patients underwent primary tumor resection that included transoral laser microsurgery and neck dissection at an academic tertiary referral center. RESULTS: Of 65 identified patients treated between 1986 and 2015 (18 oral cavity, 30 oropharynx, 17 hypopharynx), 21 (32%) received postoperative radiotherapy, and 44 (68%) were treated by surgery alone. The group of patients receiving postoperative treatment showed a significantly superior 5-year disease-specific (94.4% vs. 73.2%, P = .029) and recurrence-free survival (85.2% vs. 43.2%, P = .002), as well as a higher local control rate (90.2% vs. 64.9%, P = .042). The overall survival was 71.4% vs. 62.6% (P = .53). The mean follow-up was 80.7 months. CONCLUSIONS: Patients with locally circumscribed carcinomas and a single ipsilateral ECS-negative lymph node metastasis seem to benefit from postoperative radiotherapy. LEVEL OF EVIDENCE: 4 Laryngoscope, 2019.
- Issue Date
- 2019
- Journal
- The Laryngoscope
- Organization
- Universitätsmedizin Göttingen
- ISSN
- 0023-852X
- eISSN
- 1531-4995
- ISSN
- 1531-4995; 0023-852X
- eISSN
- 1531-4995
- Language
- English