N-cadherin regulates cytoskeletally associated lQGAP1/ERK signaling and memory formation
2007 | journal article; research paper. A publication with affiliation to the University of Göttingen.
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- Authors
- Schrick, Christina; Fischer, Andre ; Srivastava, Deepak P.; Tronson, Natalie C.; Penzes, Peter; Radulovic, Jelena
- Abstract
- Cadherin-mediated interactions are integral to synapse formation and potentiation. Here we show that N-cadherin is required for memory formation and regulation of a subset of underlying biochemical processes. N-cadherin antagonistic peptide containing the His-Ala-Val motif (HAV-N) transiently disrupted hippocampal N-cadherin dimerization and impaired the formation of long-term contextual fear memory while sparing short-term memory, retrieval, and extinction. HAV-N impaired the learning-induced phosphorylation of a distinctive, cytoskeletally associated fraction of hippocampal Erk-1/2 and altered the distribution of IQGAP1, a scaffold protein linking cadherin-mediated cell adhesion to the cytoskeleton. This effect was accompanied by reduction of N-cadherin/ IQGAP1/Erk-2 interactions. Similarly, in primary neuronal cultures, HAV-N prevented NMDA-induced dendritic Erk-1/2 phosphorylation and caused relocation of IQGAP1 from dendritic spines into the shafts. The data suggest that the newly identified role of hippocampal N-cadherin in memory consolidation may be mediated, at least in part, by cytoskeletal IQGAP1/Erk signaling.
- Issue Date
- 2007
- Journal
- Neuron
- ISSN
- 0896-6273
- Language
- English