SFB 1002 | A08: Translationale und posttranslationale Kontrolle trunkierter Titinproteine in Kardiomyozyten von Patienten mit dilatativer Kardiomyopathie RSS Feed


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  • 2023 Journal Article | Overview
    ​ ​Titin takes centerstage among cytoskeletal contributions to myocardial passive stiffness​
    Loescher, C. M. & Linke, W. A.​ (2023) 
    Cytoskeleton,.​ DOI: https://doi.org/10.1002/cm.21827 
    Details  DOI  PMID  PMC 
  • 2023 Journal Article
    ​ ​The history-dependent features of muscle force production: A challenge to the cross-bridge theory and their functional implications​
    Hahn, D.; Han, S.-W. & Joumaa, V.​ (2023) 
    Journal of Biomechanics152 art. 111579​.​ DOI: https://doi.org/10.1016/j.jbiomech.2023.111579 
    Details  DOI  PMID  PMC 
  • 2022 Journal Article
    ​ ​Titin force in muscle cells alters lattice order, thick and thin filament protein formation​
    Hessel, A. L.; Ma, W.; Mazara, N.; Rice, P. E.; Nissen, D.; Gong, H. & Kuehn, M. et al.​ (2022) 
    Proceedings of the National Academy of Sciences of the United States of America119(48) art. e2209441119​.​ DOI: https://doi.org/10.1073/pnas.2209441119 
    Details  DOI  PMID  PMC 
  • 2019 Journal Article | Research Paper
    ​ ​The Translational Landscape of the Human Heart​
    van Heesch, S.; Witte, F.; Schneider-Lunitz, V.; Schulz, J. F; Adami, E.; Faber, A. B. & Kirchner, M. et al.​ (2019) 
    Cell178(1) pp. 242.e29​-260.e29​.​ DOI: https://doi.org/10.1016/j.cell.2019.05.010 
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  • 2019 Journal Article | Research Paper
    ​ ​Cronos Titin Is Expressed in Human Cardiomyocytes and Necessary for Normal Sarcomere Function​
    Zaunbrecher, R. J.; Abel, A. N.; Beussman, K.; Leonard, A.; von Frieling-Salewsky, M.; Fields, P. A. & Pabon, L. et al.​ (2019) 
    Circulation140(20) pp. 1647​-1660​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.119.039521 
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  • 2018 Journal Article | Overview
    ​ ​Titin as a force generating muscle protein under regulatory control​
    Freundt, J. K. & Linke, W. A. ​ (2018) 
    Journal of Applied Physiology,.​ DOI: https://doi.org/10.1152/japplphysiol.00865.2018 
    Details  DOI 
  • 2018 Journal Article | Research Paper
    ​ ​A-Band Titin Truncation in Zebrafish Causes Dilated Cardiomyopathy and Hemodynamic Stress Intolerance​
    Huttner, I. G.; Wang, L. W.; Santiago, C. F.; Horvat, C.; Johnson, R.; Cheng, D. & von Frieling-Salewsky, M. et al.​ (2018) 
    Circulation: Genomic and Precision Medicine11(8) art. e002135​.​ DOI: https://doi.org/10.1161/CIRCGEN.118.002135 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | Research Paper
    ​ ​Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing​
    Long, C.; Li, H.; Tiburcy, M. ; Rodriguez-Caycedo, C.; Kyrychenko, V.; Zhou, H. & Zhang, Y. et al.​ (2018) 
    Science Advances4(1) art. eaap9004​.​ DOI: https://doi.org/10.1126/sciadv.aap9004 
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  • 2018 Journal Article | Overview
    ​ ​Titin Gene and Protein Functions in Passive and Active Muscle​
    Linke, W. A. ​ (2018) 
    Annual Review of Physiology80(1) pp. 389​-411​.​ DOI: https://doi.org/10.1146/annurev-physiol-021317-121234 
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  • 2017 Journal Article | Research Paper
    ​ ​Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair​
    Tiburcy, M. ; Hudson, J. E.; Balfanz, P.; Schlick, S.; Meyer, T. ; Chang Liao, M.-L. & Levent, E. et al.​ (2017) 
    Circulation135(19) pp. 1832​-1847​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.116.024145 
    Details  DOI 
  • 2017 Journal Article | Research Paper
    ​ ​Titin-truncating variants affect heart function in disease cohorts and the general population​
    Schäfer, S. ; de Marvao, A.; Adami, E.; Fiedler, L. R.; Ng, B.; Khin, E. & Rackham, O. J. L. et al.​ (2017) 
    Nature Genetics49(1) pp. 46​-53​.​ DOI: https://doi.org/10.1038/ng.3719 
    Details  DOI  PMID  PMC 
  • 2016 Journal Article | Research Paper
    ​ ​Cardioprotection and lifespan extension by the natural polyamine spermidine​
    Eisenberg, T.; Abdellatif, M.; Schroeder, S.; Primessnig, U.; Stekovic, S.; Pendl, T. & Harger, A. et al.​ (2016) 
    Nature Medicine22(12) pp. 1428​-1438​.​ DOI: https://doi.org/10.1038/nm.4222 
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  • 2015 Journal Article | Research Paper
    ​ ​Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy​
    Hinson, J. T.; Chopra, A.; Nafissi, N.; Polacheck, W. J.; Benson, C. C.; Swist, S. & Gorham, J. et al.​ (2015) 
    Science349(6251) pp. 982​-986​.​ DOI: https://doi.org/10.1126/science.aaa5458 
    Details  DOI  PMID  PMC 
  • 2014 Journal Article | Overview
    ​ ​Gigantic Business: ​Titin Properties and Function Through Thick and Thin​
    Linke, W. A.   & Hamdani, N.​ (2014) 
    Circulation Research114(6) pp. 1052​-1068​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.114.301286 
    Details  DOI 
  • 2014 Journal Article | Research Paper
    ​ ​Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins​
    Kötter, S.; Unger, A.; Hamdani, N.; Lang, P.; Vorgerd, M.; Nagel-Steger, L. & Linke, W. A. ​ (2014) 
    The Journal of Cell Biology204(2) pp. 187​-202​.​ DOI: https://doi.org/10.1083/jcb.201306077 
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  • 2014 Journal Article | Research Paper
    ​ ​S-Glutathionylation of Cryptic Cysteines Enhances Titin Elasticity by Blocking Protein Folding​
    Alegre-Cebollada, J.; Kosuri, P.; Giganti, D.; Eckels, E.; Rivas-Pardo, J. A.; Hamdani, N. & Warren, C. M. et al.​ (2014) 
    Cell156(6) pp. 1235​-1246​.​ DOI: https://doi.org/10.1016/j.cell.2014.01.056 
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  • 2013 Journal Article | Research Paper
    ​ ​Crucial Role for Ca2+/Calmodulin-Dependent Protein Kinase-II in Regulating Diastolic Stress of Normal and Failing Hearts via Titin Phosphorylation​
    Hamdani, N.; Krysiak, J.; Kreusser, M. M.; Neef, S.; dos Remedios, C. G.; Maier, L. S. & Krueger, M. et al.​ (2013) 
    Circulation Research112(4) pp. 664​-+​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.111.300105 
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  • 2013 Journal Article | Research Paper
    ​ ​Deranged myofilament phosphorylation and function in experimental heart failure with preserved ejection fraction​
    Hamdani, N.; Bishu, K. G.; von Frieling-Salewsky, M.; Redfield, M. M. & Linke, W. A. ​ (2013) 
    Cardiovascular Research97(3) pp. 464​-471​.​ DOI: https://doi.org/10.1093/cvr/cvs353 
    Details  DOI  PMID  PMC 
  • 2013 Journal Article | Research Paper
    ​ ​Lysine methyltransferase Smyd2 regulates Hsp90-mediated protection of the sarcomeric titin springs and cardiac function​
    Voelkel, T.; Andresen, C.; Unger, A.; Just, S.; Rottbauer, W. & Linke, W. A. ​ (2013) 
    Biochimica et Biophysica Acta (BBA) - Molecular Cell Research1833(4) pp. 812​-822​.​ DOI: https://doi.org/10.1016/j.bbamcr.2012.09.012 
    Details  DOI  PMID  PMC  WoS 

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