Prof. Dr. Reinhard Lührmann

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  • 2021 | Journal Article | 
    ​ ​Structural insights into how Prp5 proofreads the pre-mRNA branch site​
    Zhang, Z.; Rigo, N.; Dybkov, O.; Fourmann, J.-B.; Will, C. L.; Kumar, V. & Urlaub, H.  et al.​ (2021) 
    Nature, 596(7871) pp. 296​-300​.​ DOI: https://doi.org/10.1038/s41586-021-03789-5 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Structural Insights into the Roles of Metazoan-Specific Splicing Factors in the Human Step 1 Spliceosome​
    Bertram, K.; El Ayoubi, L.; Dybkov, O.; Agafonov, D. E.; Will, C. L.; Hartmuth, K. & Urlaub, H.  et al.​ (2020) 
    Molecular Cell, 80(1) pp. 127​-139.e6​.​ DOI: https://doi.org/10.1016/j.molcel.2020.09.012 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Molecular architecture of the human 17S U2 snRNP​
    Zhang, Z.; Will, C. L.; Bertram, K.; Dybkov, O.; Hartmuth, K.; Agafonov, D. E. & Hofele, R. et al.​ (2020) 
    Nature, 583(7815) pp. 310​-313​.​ DOI: https://doi.org/10.1038/s41586-020-2344-3 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes​
    Kastner, B.; Will, C. L.; Stark, H.   & Lührmann, R. ​ (2019) 
    Cold Spring Harbor Perspectives in Biology, 11(11) pp. a032417​.​ DOI: https://doi.org/10.1101/cshperspect.a032417 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​The RES complex is required for efficient transformation of the precatalytic B spliceosome into an activated B act complex​
    Bao, P.; Will, C. L.; Urlaub, H. ; Boon, K.-L.   & Lührmann, R. ​ (2018) 
    Genes & Development, 31(23-24) pp. 2416​-2429​.​ DOI: https://doi.org/10.1101/gad.308163.117 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds​
    Cretu, C. ; Agrawal, A. A.; Cook, A.; Will, C. L.; Fekkes, P.; Smith, P. G. & Lührmann, R.  et al.​ (2018) 
    Molecular Cell, 70(2) pp. 265​-273.e8​.​ DOI: https://doi.org/10.1016/j.molcel.2018.03.011 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article
    ​ ​Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation​
    Bertram, K.; Agafonov, D. E.; Dybkov, O.; Haselbach, D.; Leelaram, M. N.; Will, C. L. & Urlaub, H.  et al.​ (2017) 
    Cell, 170(4) pp. 701​-713.e11​.​ DOI: https://doi.org/10.1016/j.cell.2017.07.011 
    ​Details  DOI 
  • 2017 | Journal Article | 
    ​ ​Cryo-EM structure of a human spliceosome activated for step 2 of splicing​
    Bertram, K.; Agafonov, D. E.; Liu, W.-T.; Dybkov, O.; Will, C. L.; Hartmuth, K. & Urlaub, H.  et al.​ (2017) 
    Nature, 542(7641) pp. 318​.​ DOI: https://doi.org/10.1038/nature21079 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article
    ​ ​Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations​
    Cretu, C. ; Schmitzova, J.; Ponce-Salvatierra, A.; Dybkov, O.; De laurentiis, E. I.; Sharma, K. & Will, C. L. et al.​ (2016) 
    Molecular Cell, 64(2) pp. 307​-319​.​ DOI: https://doi.org/10.1016/j.molcel.2016.08.036 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper | 
    ​ ​A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity​
    Boesler, C.; Rigo, N.; Anokhina, M. M.; Tauchert, M. J. ; Agafonov, D. E.; Kastner, B. & Urlaub, H.  et al.​ (2016) 
    Nature Communications, 7 art. 11997​.​ DOI: https://doi.org/10.1038/ncomms11997 
    ​Details  DOI  PMID  PMC  WoS 
  • 2007 | Journal Article
    ​ ​Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes​
    Behzadnia, N.; Golas, M. M.; Hartmuth, K.; Sander, B.; Kastner, B.; Deckert, J. & Dube, P. et al.​ (2007) 
    The EMBO Journal, 26(6) pp. 1737​-1748​.​ DOI: https://doi.org/10.1038/sj.emboj.7601631 
    ​Details  DOI 
  • 2006 | Journal Article
    ​ ​Protein Composition and Electron Microscopy Structure of Affinity-Purified Human Spliceosomal B Complexes Isolated under Physiological Conditions​
    Deckert, J.; Hartmuth, K.; Boehringer, D.; Behzadnia, N.; Will, C. L.; Kastner, B. & Stark, H.  et al.​ (2006) 
    Molecular and Cellular Biology, 26(14) pp. 5528​-5543​.​ DOI: https://doi.org/10.1128/MCB.00582-06 
    ​Details  DOI 
  • 2005 | Journal Article
    ​ ​Major Conformational Change in the Complex SF3b upon Integration into the Spliceosomal U11/U12 di-snRNP as Revealed by Electron Cryomicroscopy​
    Golas, M. M.; Sander, B.; Will, C. L.; Lührmann, R.   & Stark, H. ​ (2005) 
    Molecular Cell, 17(6) pp. 869​-883​.​ DOI: https://doi.org/10.1016/j.molcel.2005.02.016 
    ​Details  DOI 
  • 2003 | Journal Article | Research Paper
    ​ ​Molecular Architecture of the Multiprotein Splicing Factor SF3b​
    Golas, M. M.; Sander, B.; Will, C. L.; Lührmann, R.   & Stark, H. ​ (2003) 
    Science, 300(5621) pp. 980​-984​.​ DOI: https://doi.org/10.1126/science.1084155 
    ​Details  DOI 

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