Prof. Dr. Stefan Pöhlmann

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  • 2022 | Journal Article | Research Paper
    ​ ​Alternatives to animal models and their application in the discovery of species susceptibility to SARS-CoV-2 and other respiratory infectious pathogens: A review​
    Runft, S.; Färber, I.; Krüger, J.; Krüger, N.; Armando, F.; Rocha, C. & Pöhlmann, S.  et al.​ (2022) 
    Veterinary Pathology / Veterinary / American College of Veterinary Pathologists, pp. 030098582110736​.​ DOI: https://doi.org/10.1177/03009858211073678 
    ​Details  DOI 
  • 2022 | Journal Article
    ​ ​The effect of cilgavimab and neutralisation by vaccine-induced antibodies in emerging SARS-CoV-2 BA.4 and BA.5 sublineages​
    Arora, P.; Zhang, L.; Nehlmeier, I.; Kempf, A.; Cossmann, A.; Dopfer-Jablonka, A. & Schulz, S. R et al.​ (2022) 
    The Lancet Infectious Diseases, 22(12) pp. 1665​-1666​.​ DOI: https://doi.org/10.1016/S1473-3099(22)00693-4 
    ​Details  DOI 
  • 2021 | Journal Article
    ​ ​Molecular mechanism of inhibiting the SARS-CoV-2 cell entry facilitator TMPRSS2 with camostat and nafamostat​
    Hempel, T.; Raich, L.; Olsson, S.; Azouz, N. P.; Klingler, A. M.; Hoffmann, M. & Pöhlmann, S.  et al.​ (2021) 
    Chemical Science, 12(3) pp. 983​-992​.​ DOI: https://doi.org/10.1039/d0sc05064d 
    ​Details  DOI 
  • 2021 | Journal Article
    ​ ​Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells​
    Carpinteiro, A.; Gripp, B.; Hoffmann, M.; Pöhlmann, S. ; Hoertel, N.; Edwards, M. J. & Kamler, M. et al.​ (2021) 
    Journal of Biological Chemistry, 296 art. S0021925821004907​.​ DOI: https://doi.org/10.1016/j.jbc.2021.100701 
    ​Details  DOI 
  • 2020 | Lecture
    ​ ​Neuer Ansatz zur COVID-19-Therapie​
    Pöhlmann, S. ​ (2020)
    Ein Virus verändert die Welt: Göttinger Wissenschaftler*innen zur Corona-Pandemie; 2020-04-28​, virtuell.
    ​Details 
  • 2020 | Journal Article
    ​ ​Polymorphisms in dipeptidyl peptidase 4 reduce host cell entry of Middle East respiratory syndrome coronavirus​
    Kleine-Weber, H.; Schroeder, S.; Krüger, N.; Prokscha, A.; Naim, H. Y.; Müller, M. A. & Drosten, C. et al.​ (2020) 
    Emerging Microbes & Infections, 9(1) pp. 155​-168​.​ DOI: https://doi.org/10.1080/22221751.2020.1713705 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Nafamostat Mesylate Blocks Activation of SARS-CoV-2: New Treatment Option for COVID-19​
    Hoffmann, M.; Schroeder, S.; Kleine-Weber, H.; Müller, M. A.; Drosten, C. & Pöhlmann, S. ​ (2020) 
    Antimicrobial Agents and Chemotherapy, 64(6).​ DOI: https://doi.org/10.1128/AAC.00754-20 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells​
    Hoffmann, M.; Kleine-Weber, H. & Pöhlmann, S. ​ (2020) 
    Molecular Cell, 78(4) pp. 779​-784.e5​.​ DOI: https://doi.org/10.1016/j.molcel.2020.04.022 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies​
    Wrapp, D.; De Vlieger, D.; Corbett, K. S.; Torres, G. M.; Wang, N.; Van Breedam, W. & Roose, K. et al.​ (2020) 
    Cell, 181(5) pp. 1004​-1015.e15​.​ DOI: https://doi.org/10.1016/j.cell.2020.04.031 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Sphingosine prevents binding of SARS–CoV-2 spike to its cellular receptor ACE2​
    Edwards, M. J.; Becker, K. A.; Gripp, B.; Hoffmann, M.; Keitsch, S.; Wilker, B. & Soddemann, M. et al.​ (2020) 
    Journal of Biological Chemistry, 295(45) pp. 15174​-15182​.​ DOI: https://doi.org/10.1074/jbc.RA120.015249 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Glycan-Gold Nanoparticles as Multifunctional Probes for Multivalent Lectin–Carbohydrate Binding: Implications for Blocking Virus Infection and Nanoparticle Assembly​
    Budhadev, D.; Poole, E.; Nehlmeier, I.; Liu, Y.; Hooper, J.; Kalverda, E. & Akshath, U. S. et al.​ (2020) 
    Journal of the American Chemical Society, 142(42) pp. 18022​-18034​.​ DOI: https://doi.org/10.1021/jacs.0c06793 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor​
    Hoffmann, M.; Kleine-Weber, H.; Schroeder, S.; Krüger, N.; Herrler, T.; Erichsen, S. & Schiergens, T. S. et al.​ (2020) 
    Cell, 181(2) pp. 271​-280.e8​.​ DOI: https://doi.org/10.1016/j.cell.2020.02.052 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Tmprss2 knock-out mice are resistant to H10 influenza A virus pathogenesis​
    Lambertz, R. L. O.; Gerhauser, I.; Nehlmeier, I.; Leist, S. R.; Kollmus, H.; Pöhlmann, S.   & Schughart, K.​ (2019) 
    Journal of General Virology, 100(7) pp. 1073​-1078​.​ DOI: https://doi.org/10.1099/jgv.0.001274 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Calu-3 cells are largely resistant to entry driven by filovirus glycoproteins and the entry defect can be rescued by directed expression of DC-SIGN or cathepsin L​
    González-Hernández, M.; Müller, A.; Hoenen, T.; Hoffmann, M. & Pöhlmann, S. ​ (2019) 
    Virology, 532 pp. 22​-29​.​ DOI: https://doi.org/10.1016/j.virol.2019.03.020 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Mutations in the Spike Protein of Middle East Respiratory Syndrome Coronavirus Transmitted in Korea Increase Resistance to Antibody-Mediated Neutralization​
    Kleine-Weber, H.; Elzayat, M. T.; Wang, L.; Graham, B. S.; Müller, M. A.; Drosten, C. & Pöhlmann, S.  et al.​ (2019) 
    Journal of Virology, 93(2).​ DOI: https://doi.org/10.1128/JVI.01381-18 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Novel Virus Related to Kaposi’s Sarcoma–Associated Herpesvirus from Colobus Monkey​
    Dhingra, A.; Ganzenmueller, T.; Hage, E.; Suárez, N. M.; Mätz-Rensing, K. ; Widmer, D. & Pöhlmann, S.  et al.​ (2019) 
    Emerging Infectious Diseases, 25(8) pp. 1548​-1551​.​ DOI: https://doi.org/10.3201/eid2508.181802 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Interferon‐Induced Transmembrane Proteins Mediate Viral Evasion in Acute and Chronic Hepatitis C Virus Infection​
    Wrensch, F.; Ligat, G.; Heydmann, L.; Schuster, C.; Zeisel, M. B.; Pessaux, P. & Habersetzer, F. et al.​ (2019) 
    Hepatology, 70(5) pp. 1506​-1520​.​ DOI: https://doi.org/10.1002/hep.30699 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Kaposi Sarcoma in Mantled Guereza​
    Grewer, A.; Bleyer, M.; Mätz-Rensing, K. ; Hahn, A. S. ; Rüggeberg, T.; Babaryka, G. & Zimmermann, A. et al.​ (2019) 
    Emerging Infectious Diseases, 25(8) pp. 1552​-1555​.​ DOI: https://doi.org/10.3201/eid2508.181804 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Hemagglutinin Cleavability, Acid Stability, and Temperature Dependence Optimize Influenza B Virus for Replication in Human Airways​
    Laporte, M.; Stevaert, A.; Raeymaekers, V.; Boogaerts, T.; Nehlmeier, I.; Chiu, W. & Benkheil, M. et al.​ (2019) 
    Journal of Virology, 94(1).​ DOI: https://doi.org/10.1128/JVI.01430-19 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Tetherin Inhibits Nipah Virus but Not Ebola Virus Replication in Fruit Bat Cells​
    Hoffmann, M.; Nehlmeier, I.; Brinkmann, C.; Krähling, V.; Behner, L.; Moldenhauer, A.-S. & Krüger, N. et al.​ (2019) 
    Journal of Virology, 93(3).​ DOI: https://doi.org/10.1128/JVI.01821-18 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Spike proteins of novel MERS-coronavirus isolates from North- and West-African dromedary camels mediate robust viral entry into human target cells​
    Kleine-Weber, H.; Pöhlmann, S.   & Hoffmann, M.​ (2019) 
    Virology, 535 pp. 261​-265​.​ DOI: https://doi.org/10.1016/j.virol.2019.07.016 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​TMPRSS11A activates the influenza A virus hemagglutinin and the MERS coronavirus spike protein and is insensitive against blockade by HAI-1​
    Zmora, P.; Hoffmann, M.; Kollmus, H.; Moldenhauer, A.-S.; Danov, O.; Braun, A. & Winkler, M.  et al.​ (2018) 
    Journal of Biological Chemistry, 293(36) pp. 13863​-13873​.​ DOI: https://doi.org/10.1074/jbc.RA118.001273 
    ​Details  DOI 

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