Prof. Dr. Rubén Fernández Busnadiego

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  • 2022 | Preprint
    ​ ​The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds​
    Saha, I.; Yuste-Checa, P.; Silva Padilha, M. D.; Guo, Q.; Körner, R.; Holthusen, H.& Trinkaus, V. A. et al.​ (2022). DOI: https://doi.org/10.1101/2022.02.18.481043 
    ​Details  DOI 
  • 2021 | Preprint
    ​ ​Gel-like inclusions of C-terminal fragments of TDP-43 sequester and inhibit proteasomes in neurons​
    Riemenschneider, H.; Guo, Q.; Bader, J.; Frottin, F.; Farny, D.; Kleinberger, G.& Haass, C. et al.​ (2021). DOI: https://doi.org/10.1101/2021.03.15.435268 
    ​Details  DOI 
  • 2021 | Preprint
    ​ ​Amyloid-like aggregates cause lysosomal defects in neurons via gain-of-function toxicity​
    Riera-Tur, I.; Schäfer, T.; Hornburg, D.; Mishra, A.; Fernández-Mosquera, L.; Feigenbutz, D.& Auer, P. et al.​ (2021). DOI: https://doi.org/10.1101/2019.12.16.877431 
    ​Details  DOI 
  • 2021 | Preprint
    ​ ​PolyQ expansion does not alter the Huntingtin-HAP40 complex​
    Huang, B.; Guo, Q.; Niedermeier, M. L.; Cheng, J.; Engler, T.; Maurer, M.& Pautsch, A. et al.​ (2021). DOI: https://doi.org/10.1101/2021.02.02.429316 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper
    ​ ​Pathological polyQ expansion does not alter the conformation of the Huntingtin-HAP40 complex​
    Huang, B.; Guo, Q.; Niedermeier, M. L.; Cheng, J.; Engler, T.; Maurer, M. & Pautsch, A. et al.​ (2021) 
    Structure,.​ DOI: https://doi.org/10.1016/j.str.2021.04.003 
    ​Details  DOI  PMID  PMC 
  • 2020 | Preprint
    ​ ​In situ architecture of neuronal α-Synuclein inclusions​
    Trinkaus, V. A.; Riera-Tur, I.; Martínez-Sánchez, A.; Bäuerlein, F. J. B.; Guo, Q.; Arzberger, T.& Baumeister, W. et al.​ (2020). DOI: https://doi.org/10.1101/2020.08.07.234138 
    ​Details  DOI 
  • 2020 | Journal Article | Research Paper
    ​ ​Stress- and ubiquitylation-dependent phase separation of the proteasome​
    Yasuda, S.; Tsuchiya, H.; Kaiho, A.; Guo, Q.; Ikeuchi, K.; Endo, A. & Arai, N. et al.​ (2020) 
    Nature, 578(7794) pp. 296​-300​.​ DOI: https://doi.org/10.1038/s41586-020-1982-9 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Reliable estimation of membrane curvature for cryo-electron tomography​
    Salfer, M.; Collado, J. F.; Baumeister, W.; Fernández Busnadiego, R.   & Martínez-Sánchez, A.​ (2020) 
    PLoS Computational Biology, 16(8) pp. e1007962​.​ DOI: https://doi.org/10.1371/journal.pcbi.1007962 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Overview | 
    ​ ​Investigating the Structure of Neurotoxic Protein Aggregates Inside Cells​
    Bäuerlein, F. J. B.; Fernández Busnadiego, R.   & Baumeister, W.​ (2020) 
    Trends in Cell Biology, 30(12) pp. 951​-966​.​ DOI: https://doi.org/10.1016/j.tcb.2020.08.007 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​The evolution of the huntingtin-associated protein 40 (HAP40) in conjunction with huntingtin​
    Seefelder, M.; Alva, V.; Huang, B. ; Engler, T.; Baumeister, W.; Guo, Q. & Fernández Busnadiego, R.  et al.​ (2020) 
    BMC Evolutionary Biology, 20(1).​ DOI: https://doi.org/10.1186/s12862-020-01705-5 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Tricalbin-Mediated Contact Sites Control ER Curvature to Maintain Plasma Membrane Integrity​
    Collado, J.; Kalemanov, M.; Campelo, F.; Bourgoint, C.; Thomas, F.; Loewith, R. & Martínez-Sánchez, A. et al.​ (2019) 
    Developmental Cell, 51(4) pp. 476​-487.e7​.​ DOI: https://doi.org/10.1016/j.devcel.2019.10.018 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article
    ​ ​In Situ Architecture and Cellular Interactions of PolyQ Inclusions​
    Bäuerlein, F. J.; Saha, I.; Mishra, A.; Kalemanov, M.; Martínez-Sánchez, A.; Klein, R. & Dudanova, I. et al.​ (2017) 
    Cell, 171(1) pp. 179​-187.e10​.​ DOI: https://doi.org/10.1016/j.cell.2017.08.009 
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​Hierarchical detection and analysis of macromolecular complexes in cryo-electron tomograms using Pyto software​
    Lučić, V.; Fernández Busnadiego, R. ; Laugks, U. & Baumeister, W.​ (2016) 
    Journal of Structural Biology, 196(3) pp. 503​-514​.​ DOI: https://doi.org/10.1016/j.jsb.2016.10.004 
    ​Details  DOI 
  • 2013 | Journal Article
    ​ ​Cryo–electron tomography reveals a critical role of RIM1α in synaptic vesicle tethering​
    Fernández Busnadiego, R. ; Asano, S.; Oprisoreanu, A.-M.; Sakata, E. ; Doengi, M.; Kochovski, Z. & Zürner, M. et al.​ (2013) 
    Journal of Cell Biology, 201(5) pp. 725​-740​.​ DOI: https://doi.org/10.1083/jcb.201206063 
    ​Details  DOI 
  • 2010 | Journal Article
    ​ ​Quantitative analysis of the native presynaptic cytomatrix by cryoelectron tomography​
    Fernández Busnadiego, R. ; Zuber, B.; Maurer, U. E.; Cyrklaff, M.; Baumeister, W. & Lučić, V.​ (2010) 
    Journal of Cell Biology, 188(1) pp. 145​-156​.​ DOI: https://doi.org/10.1083/jcb.200908082 
    ​Details  DOI 

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