Prof. Dr. Rubén Fernández Busnadiego

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  • 2022 | Preprint
    ​ ​The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds​
    Saha, I.; Yuste-Checa, P.; Silva Padilha, M. D.; Guo, Q.; Körner, R.; Holthusen, H.& Trinkaus, V. A. et al.​ (2022). DOI: https://doi.org/10.1101/2022.02.18.481043 
    ​Details  DOI 
  • 2021 | Preprint
    ​ ​Gel-like inclusions of C-terminal fragments of TDP-43 sequester and inhibit proteasomes in neurons​
    Riemenschneider, H.; Guo, Q.; Bader, J.; Frottin, F.; Farny, D.; Kleinberger, G.& Haass, C. et al.​ (2021). DOI: https://doi.org/10.1101/2021.03.15.435268 
    ​Details  DOI 
  • 2021 | Preprint
    ​ ​PolyQ expansion does not alter the Huntingtin-HAP40 complex​
    Huang, B.; Guo, Q.; Niedermeier, M. L.; Cheng, J.; Engler, T.; Maurer, M.& Pautsch, A. et al.​ (2021). DOI: https://doi.org/10.1101/2021.02.02.429316 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper
    ​ ​Pathological polyQ expansion does not alter the conformation of the Huntingtin-HAP40 complex​
    Huang, B.; Guo, Q.; Niedermeier, M. L.; Cheng, J.; Engler, T.; Maurer, M. & Pautsch, A. et al.​ (2021) 
    Structure,.​ DOI: https://doi.org/10.1016/j.str.2021.04.003 
    ​Details  DOI  PMID  PMC 
  • 2020 | Preprint
    ​ ​In situ architecture of neuronal α-Synuclein inclusions​
    Trinkaus, V. A.; Riera-Tur, I.; Martínez-Sánchez, A.; Bäuerlein, F. J. B.; Guo, Q.; Arzberger, T.& Baumeister, W. et al.​ (2020). DOI: https://doi.org/10.1101/2020.08.07.234138 
    ​Details  DOI 
  • 2020 | Journal Article | Research Paper
    ​ ​Stress- and ubiquitylation-dependent phase separation of the proteasome​
    Yasuda, S.; Tsuchiya, H.; Kaiho, A.; Guo, Q.; Ikeuchi, K.; Endo, A. & Arai, N. et al.​ (2020) 
    Nature, 578(7794) pp. 296​-300​.​ DOI: https://doi.org/10.1038/s41586-020-1982-9 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​The evolution of the huntingtin-associated protein 40 (HAP40) in conjunction with huntingtin​
    Seefelder, M.; Alva, V.; Huang, B. ; Engler, T.; Baumeister, W.; Guo, Q. & Fernández Busnadiego, R.  et al.​ (2020) 
    BMC Evolutionary Biology, 20(1).​ DOI: https://doi.org/10.1186/s12862-020-01705-5 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article
    ​ ​In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment​
    Guo, Q.; Lehmer, C.; Martínez-Sánchez, A.; Rudack, T.; Beck, F.; Hartmann, H. & Pérez-Berlanga, M. et al.​ (2018) 
    Cell, 172(4) pp. 696​-705.e12​.​ DOI: https://doi.org/10.1016/j.cell.2017.12.030 
    ​Details  DOI 

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