Dr. rer. nat. Lukas Cyganek

 
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unigoe
 

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  • 2023 Preprint
    ​ ​LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome​
    Busley, A. V.; Gutiérrez-Gutiérrez, Ó.; Hammer, E.; Steinegger, M.; Böhmer, L.; Schroeder, H.& Kleinsorge, M. et al.​ (2023). DOI: https://doi.org/10.1101/2023.01.10.523203 
    Details  DOI 
  • 2022 Journal Article
    ​ ​Epigenetic mechanism of L-type calcium channel β-subunit downregulation in short QT human induced pluripotent stem cell-derived cardiomyocytes with CACNB2 mutation​
    Zhong, R.; Zhang, F.; Yang, Z.; Li, Y.; Xu, Q.; Lan, H. & Cyganek, L.  et al.​ (2022) 
    EP Europace, art. euac091​.​ DOI: https://doi.org/10.1093/europace/euac091 
    Details  DOI 
  • 2022 Preprint
    ​ ​Alteration of myocardial structure and function in RAF1-associated Noonan syndrome: Insights from cardiac disease modeling based on patient-derived iPSCs​
    Nakhaei-Rad, S.; Bazgir, F.; Dahlmann, J.; Busley, A. V.; Buchholzer, M.; Haghighi, F.& Schänzer, A. et al.​ (2022). DOI: https://doi.org/10.1101/2022.01.22.477319 
    Details  DOI 
  • 2021 Preprint
    ​ ​Single-cell transcription profiles in Bloom syndrome patients link BLM deficiency with altered condensin complex expression signatures​
    Gönenc, I. I.; Wolff, A.; Schmidt, J.; Zibat, A.; Müller, C.; Cyganek, L.  & Argyriou, L. et al.​ (2021). DOI: https://doi.org/10.1101/2021.10.01.462717 
    Details  DOI 
  • 2021 Journal Article | Research Paper
    ​ ​Truncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due to TTN mutations​
    Fomin, A.; Gärtner, A.; Cyganek, L. ; Tiburcy, M. ; Tuleta, I.; Wellers, L. & Folsche, L. et al.​ (2021) 
    Science Translational Medicine13(618).​ DOI: https://doi.org/10.1126/scitranslmed.abd3079 
    Details  DOI 
  • 2021 Journal Article
    ​ ​Abstract MP217: Nuclease-deficient Cas9 Transcription Factors Restore Krueppel-like Factor 15 Expression In Stressed Mouse And Human Cardiomyocytes​
    Schoger, E.; Rosa, K.; Rocha, C.; Jassyk, M.; Doroudgar, S.; Mueller, O. & Cyganek, L.  et al.​ (2021) 
    Circulation Research129(Suppl_1).​ DOI: https://doi.org/10.1161/res.129.suppl_1.MP217 
    Details  DOI 
  • 2021 Journal Article
    ​ ​Alpha 1-adrenoceptor signalling contributes to toxic effects of catecholamine on electrical properties in cardiomyocytes​
    Huang, M.; Fan, X.; Yang, Z.; Cyganek, L. ; Li, X.; Yuecel, G. & Lan, H. et al.​ (2021) 
    Europace23(7) pp. 1137​-1148​.​ DOI: https://doi.org/10.1093/europace/euab008 
    Details  DOI 
  • 2020 Journal Article
    ​ ​Disease Phenotypes and Mechanisms of iPSC-Derived Cardiomyocytes From Brugada Syndrome Patients With a Loss-of-Function SCN5A Mutation​
    Li, W.; Stauske, M.; Luo, X.; Wagner, S. ; Vollrath, M.; Mehnert, C. S. & Schubert, M. et al.​ (2020) 
    Frontiers in Cell and Developmental Biology8.​ DOI: https://doi.org/10.3389/fcell.2020.592893 
    Details  DOI 
  • 2020 Journal Article
    ​ ​Ionic Mechanisms of Disopyramide Prolonging Action Potential Duration in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes From a Patient With Short QT Syndrome Type 1​
    Lan, H.; Xu, Q.; El-Battrawy, I.; Zhong, R.; Li, X.; Lang, S. & Cyganek, L.  et al.​ (2020) 
    Frontiers in Pharmacology11.​ DOI: https://doi.org/10.3389/fphar.2020.554422 
    Details  DOI 
  • 2020 Journal Article | Research Paper
    ​ ​Intronic CRISPR Repair in a Preclinical Model of Noonan Syndrome–Associated Cardiomyopathy​
    Hanses, U.; Kleinsorge, M.; Roos, L.; Yigit, G. ; Li, Y. ; Barbarics, B. & El-Battrawy, I. et al.​ (2020) 
    Circulation142(11) pp. 1059​-1076​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.119.044794 
    Details  DOI  PMID  PMC 
  • 2019 Conference Paper
    ​ ​P1235Acetylcholine-activated inward-rectifier potassium currents in atrial cardiomyocytes derived from induced pluripotent stem cells and atrial engineered heart muscle preparations​
    Springer, R.; Seibertz, F.; Solano, R. A.; Rubio, T.; Cyganek, L. ; Zimmermann, W.-H.   & Voigt, N. ​ (2019)
    European Heart Journal40(Suppl. 1) ​ESC Congress 2019 together with World Congress of Cardiology​, Paris. DOI: https://doi.org/10.1093/eurheartj/ehz748.0193 
    Details  DOI 
  • 2019 Conference Abstract
    ​ ​Leaving spreadsheets behind – FAIR documentation and representation of human stem cell lines in the Collaborative Research Centre 1002 Meeting Abstract​
    Lehmann, C.; Suhr, M. ; Umbach, N.; Cyganek, L. ; Kleinsorge, M.; Nussbeck, S. Y.   & Kusch, H. ​ (2019)
    GMS German Medical Science, ​64. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS)​, Dortmund. DOI: https://doi.org/10.3205/19gmds037 
    Details  DOI 
  • 2019 Journal Article
    ​ ​‘Mature’ resting membrane potentials in hiPSC-CMs: fact or artefact?—Authors’ reply​
    El-Battrawy, I.; Cyganek, L. ; Zhou, X. & Akin, I.​ (2019) 
    Europace21(12) pp. 1928​-1929​.​ DOI: https://doi.org/10.1093/europace/euz274 
    Details  DOI 
  • 2019 Journal Article
    ​ ​Long-term follow-up of implantable cardioverter-defibrillators in Short QT syndrome​
    El-Battrawy, I.; Besler, J.; Ansari, U.; Liebe, V.; Schimpf, R.; Tülümen, E. & Rudic, B. et al.​ (2019) 
    Clinical Research in Cardiology108(10) pp. 1140​-1146​.​ DOI: https://doi.org/10.1007/s00392-019-01449-3 
    Details  DOI 
  • 2019 Journal Article | Research Paper
    ​ ​A cellular model of Brugada syndrome with SCN10A variants using human-induced pluripotent stem cell-derived cardiomyocytes​
    El-Battrawy, I.; Albers, S.; Cyganek, L. ; Zhao, Z.; Lan, H.; Li, X. & Xu, Q. et al.​ (2019) 
    Europace21(9) pp. 1410​-1421​.​ DOI: https://doi.org/10.1093/europace/euz122 
    Details  DOI  PMID  PMC 
  • 2019 Journal Article | Research Paper
    ​ ​Drug Testing in Human‐Induced Pluripotent Stem Cell–Derived Cardiomyocytes From a Patient With Short QT Syndrome Type 1​
    Zhao, Z.; Li, X.; El‐Battrawy, I.; Lan, H.; Zhong, R.; Xu, Q. & Huang, M. et al.​ (2019) 
    Clinical Pharmacology & Therapeutics106(3) pp. 642​-651​.​ DOI: https://doi.org/10.1002/cpt.1449 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | Research Paper
    ​ ​Ion Channel Dysfunctions in Dilated Cardiomyopathy in Limb-Girdle Muscular Dystrophy​
    El-Battrawy, I.; Zhao, Z.; Lan, H.; Li, X.; Yücel, G.; Lang, S. & Sattler, K. et al.​ (2018) 
    Circulation: Genomic and Precision Medicine11(3).​ DOI: https://doi.org/10.1161/CIRCGEN.117.001893 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | Research Paper
    ​ ​Electrical dysfunctions in human-induced pluripotent stem cell-derived cardiomyocytes from a patient with an arrhythmogenic right ventricular cardiomyopathy​
    El-Battrawy, I.; Zhao, Z.; Lan, H.; Cyganek, L. ; Tombers, C.; Li, X. & Buljubasic, F. et al.​ (2018) 
    Europace20(FI1) pp. f46​-f56​.​ DOI: https://doi.org/10.1093/europace/euy042 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | Research Paper
    ​ ​Modeling Short QT Syndrome Using Human‐Induced Pluripotent Stem Cell–Derived Cardiomyocytes​
    El‐Battrawy, I.; Lan, H.; Cyganek, L. ; Zhao, Z.; Li, X.; Buljubasic, F. & Lang, S. et al.​ (2018) 
    Journal of the American Heart Association7(7).​ DOI: https://doi.org/10.1161/JAHA.117.007394 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | Research Paper
    ​ ​Estradiol protection against toxic effects of catecholamine on electrical properties in human-induced pluripotent stem cell derived cardiomyocytes​
    El-Battrawy, I.; Zhao, Z.; Lan, H.; Schünemann, J.-D.; Sattler, K.; Buljubasic, F. & Patocskai, B. et al.​ (2018) 
    International Journal of Cardiology254 pp. 195​-202​.​ DOI: https://doi.org/10.1016/j.ijcard.2017.11.007 
    Details  DOI  PMID  PMC 
  • 2017 Journal Article | Research Paper
    ​ ​Stress-Activated Kinase Mitogen-Activated Kinase Kinase-7 Governs Epigenetics of Cardiac Repolarization for Arrhythmia Prevention​
    Chowdhury, S. K.; Liu, W.; Zi, M.; Li, Y.; Wang, S.; Tsui, H. & Prehar, S. et al.​ (2017) 
    Circulation135(7) pp. 683​-699​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.116.022941 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Conference Abstract
    ​ ​Custom-tailored cardiomyocytes: a directed in vitro differentiation of human pluripotent stem cells into defined cardiomyocyte subtypes​
    Cyganek, L. L. ; Sekeres, K.; Henze, S.; Li, W. & Guan, K.​ (2015)
    European Journal of Heart Failure17 
    Hoboken​: Wiley-blackwell.
    Details  WoS 
  • 2015 Conference Abstract
    ​ ​A model of anthracycline-induced cardiotoxicity using induced pluripotent stem cell-derived cardiomyocytes​
    Streckfuss-Boemeke, K.; Haupt, L.; Fomin, V. M.; Wagner, S.; Sossalla, S. T.; Cyganek, L.   & Linke, W.  et al.​ (2015)
    European Heart Journal36 , London, ENGLAND.
    Oxford​: Oxford Univ Press.
    Details  WoS 
  • 2015 Conference Abstract
    ​ ​Functional analysis of distinct ryanodine receptor type 2 mutations in induced pluripotent stem cell-derived cardiomyocytes from CPVT patients​
    Cyganek, L. L. ; Li, W.; Henze, S.; Chen, S.; Bezzina, C. R.; Wilde, A. A. M. & Guan, K.​ (2015)
    European Journal of Heart Failure17 
    Hoboken​: Wiley-blackwell.
    Details  WoS 

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