Dr. rer. nat. Lukas Cyganek

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  • 2023 | Journal Article | 
    ​ ​Electrophysiological and calcium-handling development during long-term culture of human-induced pluripotent stem cell-derived cardiomyocytes​
    Seibertz, F.; Sutanto, H.; Dülk, R.; Pronto, J. R. D.; Springer, R.; Rapedius, M. & Liutkute, A. et al.​ (2023) 
    Basic Research in Cardiology, 118(1) pp. 14​.​ DOI: https://doi.org/10.1007/s00395-022-00973-0 
    ​Details  DOI  PMID  PMC 
  • 2023 | Preprint
    ​ ​LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome​
    Busley, A. V.; Gutiérrez-Gutiérrez, Ó.; Hammer, E.; Steinegger, M.; Böhmer, L.; Schroeder, H.& Kleinsorge, M. et al.​ (2023). DOI: https://doi.org/10.1101/2023.01.10.523203 
    ​Details  DOI 
  • 2022 | Journal Article | Overview | 
    ​ ​Recent Advances in Modeling Mitochondrial Cardiomyopathy Using Human Induced Pluripotent Stem Cells​
    Pavez-Giani, M. G. & Cyganek, L. ​ (2022) 
    Frontiers in Cell and Developmental Biology, 9 art. 800529​.​ DOI: https://doi.org/10.3389/fcell.2021.800529 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | Research Paper | 
    ​ ​A review of protocols for human iPSC culture, cardiac differentiation, subtype-specification, maturation, and direct reprogramming​
    Lyra-Leite, D. M.; Gutiérrez-Gutiérrez, Ó.; Wang, M.; Zhou, Y.; Cyganek, L.   & Burridge, P. W.​ (2022) 
    STAR Protocols, 3(3) art. 101560​.​ DOI: https://doi.org/10.1016/j.xpro.2022.101560 
    ​Details  DOI 
  • 2022 | Preprint
    ​ ​Alteration of myocardial structure and function in RAF1-associated Noonan syndrome: Insights from cardiac disease modeling based on patient-derived iPSCs​
    Nakhaei-Rad, S.; Bazgir, F.; Dahlmann, J.; Busley, A. V.; Buchholzer, M.; Haghighi, F.& Schänzer, A. et al.​ (2022). DOI: https://doi.org/10.1101/2022.01.22.477319 
    ​Details  DOI 
  • 2022 | Journal Article | 
    ​ ​A modern automated patch-clamp approach for high throughput electrophysiology recordings in native cardiomyocytes​
    Seibertz, F.; Rapedius, M.; Fakuade, F. E.; Tomsits, P.; Liutkute, A.; Cyganek, L.   & Becker, N. et al.​ (2022) 
    Communications Biology, 5(1).​ DOI: https://doi.org/10.1038/s42003-022-03871-2 
    ​Details  DOI  PMID  PMC 
  • 2021 | Preprint
    ​ ​Single-cell transcription profiles in Bloom syndrome patients link BLM deficiency with altered condensin complex expression signatures​
    Gönenc, I. I.; Wolff, A.; Schmidt, J.; Zibat, A.; Müller, C.; Cyganek, L.  & Argyriou, L. et al.​ (2021). DOI: https://doi.org/10.1101/2021.10.01.462717 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper
    ​ ​Truncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due to TTN mutations​
    Fomin, A.; Gärtner, A.; Cyganek, L. ; Tiburcy, M. ; Tuleta, I.; Wellers, L. & Folsche, L. et al.​ (2021) 
    Science Translational Medicine, 13(618).​ DOI: https://doi.org/10.1126/scitranslmed.abd3079 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Establishment of a second generation homozygous CRISPRa human induced pluripotent stem cell (hiPSC) line for enhanced levels of endogenous gene activation​
    Schoger, E.; Zimmermann, W.-H. ; Cyganek, L.   & Zelarayán, L. C. ​ (2021) 
    Stem Cell Research, 56 art. S1873506121003652​.​ DOI: https://doi.org/10.1016/j.scr.2021.102518 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Monitoring mitochondrial translation in living cells​
    Yousefi, R.; Fornasiero, E. F ; Cyganek, L. ; Montoya, J.; Jakobs, S. ; Rizzoli, S. O   & Rehling, P.  et al.​ (2021) 
    EMBO reports, 22(4).​ DOI: https://doi.org/10.15252/embr.202051635 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Establishment of two homozygous CRISPR interference (CRISPRi) knock-in human induced pluripotent stem cell (hiPSC) lines for titratable endogenous gene repression​
    Schoger, E.; Zimmermann, W.-H. ; Cyganek, L.   & Zelarayán, L. C. ​ (2021) 
    Stem Cell Research, 55 art. S1873506121003202​.​ DOI: https://doi.org/10.1016/j.scr.2021.102473 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Bi-allelic missense disease-causing variants in RPL3L associate neonatal dilated cardiomyopathy with muscle-specific ribosome biogenesis​
    Ganapathi, M.; Argyriou, L.; Martínez-Azorín, F.; Morlot, S.; Yigit, G. ; Lee, T. M. & Auber, B. et al.​ (2020) 
    Human Genetics, 139(11) pp. 1443​-1454​.​ DOI: https://doi.org/10.1007/s00439-020-02188-6 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper
    ​ ​Intronic CRISPR Repair in a Preclinical Model of Noonan Syndrome–Associated Cardiomyopathy​
    Hanses, U.; Kleinsorge, M.; Roos, L.; Yigit, G. ; Li, Y. ; Barbarics, B. & El-Battrawy, I. et al.​ (2020) 
    Circulation, 142(11) pp. 1059​-1076​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.119.044794 
    ​Details  DOI  PMID  PMC 

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