Real‐Time Magnetic Resonance Imaging to Study Orthostatic Intolerance Mechanisms in Human Beings: Proof of Concept
2022 | journal article. A publication with affiliation to the University of Göttingen.
Jump to: Cite & Linked | Documents & Media | Details | Version history
Cite this publication
Real‐Time Magnetic Resonance Imaging to Study Orthostatic Intolerance Mechanisms in Human Beings: Proof of Concept
Gerlach, D. A.; Maier, A.; Manuel, J.; Bach, A.; Hoff, A.; Hönemann, J. & Heusser, K. et al. (2022)
Journal of the American Heart Association, art. e026437. DOI: https://doi.org/10.1161/JAHA.122.026437
Documents & Media
Details
- Authors
- Gerlach, Darius A.; Maier, Andrea; Manuel, Jorge; Bach, Anja; Hoff, Alex; Hönemann, Jan‐Niklas; Heusser, Karsten; Voit, Dirk; Frahm, Jens ; Jordan, Jens; Tank, Jens
- Abstract
- Background Discerning the mechanisms driving orthostatic symptoms in human beings remains challenging. Therefore, we developed a novel approach combining cardiac and cerebral real‐time magnetic resonance imaging, beat‐to‐beat physiological monitoring, and orthostatic stress testing through lower‐body negative pressure (LBNP). We conducted a proof‐of‐concept study in a patient with severe orthostatic hypotension. Methods and Results We included a 46‐year‐old man with pure autonomic failure. Without and during −30 mmHg LBNP , we obtained 3T real‐time magnetic resonance imaging of the cardiac short axis and quantitative flow measurements in the pulmonary trunk and middle cerebral artery. Blood pressure was 118/74 mmHg during supine rest and 58/35 mmHg with LBNP . With LBNP , left ventricular stroke volume decreased by 44.6%, absolute middle cerebral artery flow by 37.6%, and pulmonary trunk flow by 40%. Conclusions Combination of real‐time magnetic resonance imaging, LBNP , and continuous blood pressure monitoring provides a promising new approach to study orthostatic intolerance mechanisms in human beings.
- Issue Date
- 2022
- Journal
- Journal of the American Heart Association
- Organization
- Max-Planck-Institut für Multidisziplinäre Naturwissenschaften
- eISSN
- 2047-9980
- Language
- English