Neuronal extracellular vesicles and associated microRNAs induce circuit connectivity downstream BDNF
2023-02-06 | journal article
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Cite this publication
Neuronal extracellular vesicles and associated microRNAs induce circuit connectivity downstream BDNF
Antoniou, A.; Auderset, L.; Kaurani, L.; Sebastian, E.; Zeng, Y.; Allahham, M. & Cases-Cunillera, S. et al. (2023)
Cell Reports, 42(2) art. 112063. DOI: https://doi.org/10.1016/j.celrep.2023.112063
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Details
- Authors
- Antoniou, Anna; Auderset, Loic; Kaurani, Lalit; Sebastian, Eva; Zeng, Yuzhou; Allahham, Maria; Cases-Cunillera, Silvia; Schoch, Susanne; Gruendemann, Jan; Fischer, André ; Schneider, Anja
- Abstract
- Extracellular vesicles (EVs) have emerged as mediators of cellular communication, in part via the delivery of associated microRNAs (miRNAs), small non-coding RNAs that regulate gene expression. We show that brain-derived neurotrophic factor (BDNF) mediates the sorting of miR-132-5p, miR-218-5p, and miR-690 in neuron-derived EVs. BDNF-induced EVs in turn increase excitatory synapse formation in recipient hippocampal neurons, which is dependent on the inter-neuronal delivery of these miRNAs. Transcriptomic analysis further indicates the differential expression of developmental and synaptogenesis-related genes by BDNF-induced EVs, many of which are predicted targets of miR-132-5p, miR-218-5p, and miR-690. Furthermore, BDNF-induced EVs up-regulate synaptic vesicle (SV) clustering in a transmissible manner, thereby increasing synaptic transmission and synchronous neuronal activity. As BDNF and EV-miRNAs miR-218 and miR-132 were previously implicated in neuropsychiatric disorders such as anxiety and depression, our results contribute to a better understanding of disorders characterized by aberrant neural circuit connectivity.
- Issue Date
- 6-February-2023
- Journal
- Cell Reports
- Project
- EXC 2067: Multiscale Bioimaging
SFB 1286: Quantitative Synaptologie
SFB 1286 | B06: Die Rolle von RNA in Synapsenphysiologie und Neurodegeneration - Working Group
- RG A. Fischer (Epigenetics and Systems Medicine in Neurodegenerative Diseases)
- eISSN
- 2211-1247
- Language
- English