Comparison of cine and real-time cardiac MRI in rhesus macaques
2021-05-21 | journal article. A publication with affiliation to the University of Göttingen.
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Comparison of cine and real-time cardiac MRI in rhesus macaques
Moussavi, A.; Mißbach, S.; Serrano Ferrel, C.; Ghasemipour, H.; Kötz, K.; Drummer, C. & Behr, R. et al. (2021)
Scientific Reports, 11(1) art. 10713. DOI: https://doi.org/10.1038/s41598-021-90106-9
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Details
- Authors
- Moussavi, Amir; Mißbach, Sophie; Serrano Ferrel, Claudia; Ghasemipour, Hasti; Kötz, Kristin; Drummer, Charis; Behr, Rüdiger; Zimmermann, Wolfram-Hubertus; Boretius, Susann
- Abstract
- Abstract Cardiac MRI in rhesus macaques, a species of major relevance for preclinical studies on biological therapies, requires artificial ventilation to realize breath holding. To overcome this limitation of standard cine MRI, the feasibility of Real-Time (RT) cardiac MRI has been tested in a cohort of ten adult rhesus macaques using a clinical MR-system. In spite of lower tissue contrast and sharpness of RT-MRI, cardiac functions were similarly well assessed by RT-MRI compared to cine MRI (similar intra-subject repeatability). However, systematic underestimation of the end-diastolic volume (31 ± 9%), end-systolic volume (20 ± 11%), stroke volume (40 ± 12%) and ejection fraction (13 ± 9%) hamper the comparability of RT-MRI results with those of other cardiac MRI methods. Yet, the underestimations were very consistent (< 5% variability) for repetitive measurements, making RT-MRI an appropriate alternative to cine MRI for longitudinal studies. In addition, RT-MRI enabled the analysis of cardio-respiratory coupling. All functional parameters showed lower values during expiration compared to inspiration, most likely due to the pressure-controlled artificial ventilation. In conclusion, despite systematic underestimation of the functional parameters, RT-MRI allowed the assessment of left ventricular function in macaques with significantly less experimental effort, measurement time, risk and burden for the animals compared to cine MRI.
- Issue Date
- 21-May-2021
- Journal
- Scientific Reports
- eISSN
- 2045-2322
- Language
- English
- Sponsor
- Deutsches Primatenzentrum GmbH - Leibniz-Institut für Primatenforschung (1021)