Impaired calcium homeostasis is associated with sudden cardiac death and arrhythmias in a genetic equivalent mouse model of the human HRC-Ser96Ala variant
2017 | journal article
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Impaired calcium homeostasis is associated with sudden cardiac death and arrhythmias in a genetic equivalent mouse model of the human HRC-Ser96Ala variant
Tzimas, C.; Johnson, D. M.; Santiago, D. J.; Vafiadaki, E.; Arvanitis, D. A.; Davos, C. H. & Varela, A. et al. (2017)
Cardiovascular Research, 113(11) pp. 1403-1417. DOI: https://doi.org/10.1093/cvr/cvx113
Documents & Media
Details
- Authors
- Tzimas, Christos; Johnson, Daniel M.; Santiago, Demetrio J.; Vafiadaki, Elizabeth; Arvanitis, Demetrios A.; Davos, Constantinos H.; Varela, Aimilia; Athanasiadis, Nikolaos C.; Dimitriou, Constantinos; Katsimpoulas, Michalis; Sonntag, Stephan; Kryzhanovska, Mariya; Shmerling, Doron; Lehnart, Stephan Elmar ; Sipido, Karin R.; Kranias, Evangelia G.; Sanoudou, Despina
- Abstract
- The histidine-rich calcium-binding protein (HRC) Ser96Ala variant has previously been identified as a potential biomarker for ventricular arrhythmias and sudden cardiac death in patients with idiopathic dilated cardiomyopathy. Herein, the role of this variant in cardiac pathophysiology is delineated through a novel mouse model, carrying the human mutation in the homologous mouse position.
- Issue Date
- 2017
- Journal
- Cardiovascular Research
- ISSN
- 1755-3245
- eISSN
- 1755-3245
- Language
- English
