Optogenetic Light Crafting Tools for the Control of Cardiac Arrhythmias
2016 | book part
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Cite this publication
Optogenetic Light Crafting Tools for the Control of Cardiac Arrhythmias
Richter, C. ; Christoph, J. ; Lehnart, S. E. & Luther, S. (2016)
In:Kianianmomeni, Arash (Ed.), Optogenetics: Methods and Protocols pp. 293-302. New York: Humana Press. DOI: https://doi.org/10.1007/978-1-4939-3512-3_20
Documents & Media
Details
- Authors
- Richter, Claudia ; Christoph, Jan ; Lehnart, Stephan Elmar ; Luther, Stefan
- Editors
- Kianianmomeni, Arash
- Abstract
- The control of spatiotemporal dynamics in biological systems is a fundamental problem in nonlinear sciences and has important applications in engineering and medicine. Optogenetic tools combined with advanced optical technologies provide unique opportunities to develop and validate novel approaches to control spatiotemporal complexity in neuronal and cardiac systems. Understanding of the mechanisms and instabilities underlying the onset, perpetuation, and control of cardiac arrhythmias will enable the development and translation of novel therapeutic approaches. Here we describe in detail the preparation and optical mapping of transgenic channelrhodopsin-2 (ChR2) mouse hearts, cardiac cell cultures, and the optical setup for photostimulation using digital light processing.
- Issue Date
- 2016
- Publisher
- Humana Press
- Project
- SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz
SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung - Working Group
- RG Lehnart (Cellular Biophysics and Translational Cardiology Section)
RG Luther (Biomedical Physics) - Series
- Methods in Molecular Biology
- ISBN
- 978-1-4939-3512-3
978-1-4939-3510-9
978-1-4939-3512-3 - ISSN
- 1940-6029
- eISSN
- 1940-6029
- Language
- English
