Calcium/calmodulin-dependent protein kinase II (CaMKII) inhibition ameliorates arrhythmias elicited by junctin ablation under stress conditions
2015 | journal article
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Calcium/calmodulin-dependent protein kinase II (CaMKII) inhibition ameliorates arrhythmias elicited by junctin ablation under stress conditions
Tzimas, C.; Terrovitis, J.; Lehnart, S. E. ; Kranias, E. G. & Sanoudou, D. (2015)
Heart Rhythm, 12(7) pp. 1599-1610. DOI: https://doi.org/10.1016/j.hrthm.2015.03.043
Documents & Media
Details
- Authors
- Tzimas, Christos; Terrovitis, John; Lehnart, Stephan Elmar ; Kranias, Evangelia G.; Sanoudou, Despina
- Abstract
- Aberrant calcium signaling is considered one of the key mechanisms contributing to arrhythmias, especially in the context of heart failure. In human heart failure, there is significant down-regulation of the sarcoplasmic reticulum (SR) protein junctin, and junctin deficiency in mice is associated with stress-induced arrhythmias.
- Issue Date
- 2015
- Journal
- Heart Rhythm
- ISSN
- 1556-3871
- eISSN
- 1556-3871
- Language
- English
