A mouse model of Streptococcus pneumoniae meningitis mimicking several features of human disease
2001 | journal article. A publication with affiliation to the University of Göttingen.
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A mouse model of Streptococcus pneumoniae meningitis mimicking several features of human disease
Gerber, J.; Raivich, G.; Wellmer, A.; Noeske, C.; Kunst, T.; Werner, A. & Bruck, W. W. et al. (2001)
Acta Neuropathologica, 101(5) pp. 499-508.
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- Authors
- Gerber, Joachim; Raivich, G.; Wellmer, A.; Noeske, C.; Kunst, T.; Werner, A.; Bruck, Wolfgang W.; Nau, R.
- Abstract
- The course of bacterial titers, meningeal inflammation, behavioral abnormalities, and neuronal damage was studied in a mouse model of Streptococcus pneumoniae meningitis. At 24 h after injection of 10(4) colony-forming units (CFU) S. pneumoniae into the right forebrain, infected mice became severely lethargic. Bacterial titers in cerebrospinal fluid and cerebellum rose to 10(9) CFU/ml, with strong granulocyte invasion into the meninges and neuronal necroses in the neocortex, striatum and hippocampal formation. Meningeal inflammation and neuronal damage in intercellular cell adhesion molecule-1- and macrophage colony-stimulating factor-deficient mice was similar to that in wild-type litrermates. Untreated, the infection was fatal. Wild-type mice treated earlier than 24 h after infection with ceftriaxone (2 mg every 12 h for 3 days) survived without apparent behavioral abnormalities. Delay of treatment beyond 30 h led to the death of more than 50% of the infected mice. This mouse model is suitable fur therapeutic studies and for the investigation of inflammation in knockout mice. The neuronal damage resembles morphological abnormalities observed in humans.
- Issue Date
- 2001
- Status
- published
- Publisher
- Springer
- Journal
- Acta Neuropathologica
- ISSN
- 0001-6322