Acta Neuropathologica

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  • 2023 Journal Article | 
    ​ ​IL-10-providing B cells govern pro-inflammatory activity of macrophages and microglia in CNS autoimmunity​
    Geladaris, A.; Häusser-Kinzel, S.; Pretzsch, R.; Nissimov, N.; Lehmann-Horn, K.; Häusler, D. & Weber, M. S.​ (2023) 
    Acta Neuropathologica145(4) pp. 461​-477​.​ DOI: https://doi.org/10.1007/s00401-023-02552-6 
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  • 2023 Journal Article | Erratum | 
    ​ ​Correction to: Amplification of the PLAG-family genes—PLAGL1 and PLAGL2—is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification​
    Keck, M.-K.; Sill, M.; Wittmann, A.; Joshi, P.; Stichel, D.; Beck, P. & Okonechnikow, K. et al.​ (2023) 
    Acta Neuropathologica,.​ DOI: https://doi.org/10.1007/s00401-023-02538-4 
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  • 2023 Journal Article | Overview
    ​ ​More than meets the eye in Parkinson’s disease and other synucleinopathies: from proteinopathy to lipidopathy​
    Flores-Leon, M. & Outeiro, T. F.​ (2023) 
    Acta Neuropathologica146(3) pp. 369​-385​.​ DOI: https://doi.org/10.1007/s00401-023-02601-0 
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  • 2022 Journal Article | 
    ​ ​Hemorrhagic lesion with detection of infected endothelial cells in human bornavirus encephalitis​
    Liesche-Starnecker, F.; Schifferer, M. ; Schlegel, J.; Vollmuth, Y.; Rubbenstroth, D.; Delbridge, C. & Gempt, J. et al.​ (2022) 
    Acta Neuropathologica144(2) pp. 377​-379​.​ DOI: https://doi.org/10.1007/s00401-022-02442-3 
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  • 2022 Journal Article
    ​ ​Pyroptosis in Alzheimer’s disease: cell type-specific activation in microglia, astrocytes and neurons​
    Moonen, S.; Koper, M. J.; Van Schoor, E.; Schaeverbeke, J. M.; Vandenberghe, R.; von Arnim, C. A. F. & Tousseyn, T. et al.​ (2022) 
    Acta Neuropathologica,.​ DOI: https://doi.org/10.1007/s00401-022-02528-y 
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  • 2022 Journal Article | 
    ​ ​Amplification of the PLAG-family genes—PLAGL1 and PLAGL2—is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification​
    Keck, M.-K.; Sill, M.; Wittmann, A.; Joshi, P.; Stichel, D.; Beck, P. & Okonechnikow, K. et al.​ (2022) 
    Acta Neuropathologica,.​ DOI: https://doi.org/10.1007/s00401-022-02516-2 
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  • 2022 Journal Article | 
    ​ ​Donanemab detects a minor fraction of amyloid-β plaques in post-mortem brain tissue of patients with Alzheimer’s disease and Down syndrome​
    Bouter, Y.; Liekefeld, H.; Pichlo, S.; Westhoff, A. C.; Fenn, L.; Bakrania, P. & Bayer, T. A.​ (2022) 
    Acta Neuropathologica143(5) pp. 601​-603​.​ DOI: https://doi.org/10.1007/s00401-022-02418-3 
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  • 2022 Journal Article | Erratum
    ​ ​Correction to: Flow blockage disrupts cilia-driven fluid transport in the epileptic brain​
    Faubel, R. J.; Santos Canellas, V. S.; Gaesser, J.; Beluk, N. H.; Feinstein, T. N.; Wang, Y. & Yankova, M. et al.​ (2022) 
    Acta Neuropathologica,.​ DOI: https://doi.org/10.1007/s00401-022-02496-3 
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  • 2022 Journal Article | 
    ​ ​Flow blockage disrupts cilia-driven fluid transport in the epileptic brain​
    Faubel, R. J.; Santos Canellas, V. S.; Gaesser, J.; Beluk, N. H.; Feinstein, T. N.; Wang, Y. & Yankova, M. et al.​ (2022) 
    Acta Neuropathologica,.​ DOI: https://doi.org/10.1007/s00401-022-02463-y 
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  • 2022 Journal Article | 
    ​ ​Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers​
    Jansen, I. E.; van der Lee, S. J.; Gomez-Fonseca, D.; de Rojas, I.; Dalmasso, M. C.; Grenier-Boley, B. & Zettergren, A. et al.​ (2022) 
    Acta Neuropathologica,.​ DOI: https://doi.org/10.1007/s00401-022-02454-z 
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  • 2021 Journal Article
    ​ ​Maturation of neuronal AD-tau pathology involves site-specific phosphorylation of cytoplasmic and synaptic tau preceding conformational change and fibril formation​
    Aragão Gomes, L.; Uytterhoeven, V.; Lopez-Sanmartin, D.; Tomé, S. O.; Tousseyn, T.; Vandenberghe, R. & Vandenbulcke, M. et al.​ (2021) 
    Acta Neuropathologica141(2) pp. 173​-192​.​ DOI: https://doi.org/10.1007/s00401-020-02251-6 
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  • 2021 Journal Article
    ​ ​Huntington’s disease brain-derived small RNAs recapitulate associated neuropathology in mice​
    Creus-Muncunill, J.; Guisado-Corcoll, A.; Venturi, V.; Pantano, L.; Escaramís, G.; García de Herreros, M. & Solaguren-Beascoa, M. et al.​ (2021) 
    Acta Neuropathologica141(4) pp. 565​-584​.​ DOI: https://doi.org/10.1007/s00401-021-02272-9 
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  • 2021 Journal Article | 
    ​ ​Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors​
    Sievers, P.; Henneken, S. C.; Blume, C.; Sill, M.; Schrimpf, D.; Stichel, D. & Okonechnikov, K. et al.​ (2021) 
    Acta Neuropathologica,.​ DOI: https://doi.org/10.1007/s00401-021-02356-6 
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  • 2021 Journal Article | 
    ​ ​PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum​
    Alhalabi, K. T.; Stichel, D.; Sievers, P.; Peterziel, H.; Sommerkamp, A. C.; Sturm, D. & Wittmann, A. et al.​ (2021) 
    Acta Neuropathologica,.​ DOI: https://doi.org/10.1007/s00401-021-02354-8 
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  • 2021 Journal Article | 
    ​ ​Making sense of missense variants in TTN-related congenital myopathies​
    Rees, M.; Nikoopour, R.; Fukuzawa, A.; Kho, A. L.; Fernandez-Garcia, M. A.; Wraige, E. & Bodi, I. et al.​ (2021) 
    Acta Neuropathologica141(3) pp. 431​-453​.​ DOI: https://doi.org/10.1007/s00401-020-02257-0 
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  • 2021 Journal Article | 
    ​ ​GOPC:ROS1 and other ROS1 fusions represent a rare but recurrent drug target in a variety of glioma types​
    Sievers, P.; Stichel, D.; Sill, M.; Schrimpf, D.; Sturm, D.; Selt, F. & Ecker, J. et al.​ (2021) 
    Acta Neuropathologica,.​ DOI: https://doi.org/10.1007/s00401-021-02369-1 
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  • 2021 Journal Article | 
    ​ ​TREM2 expression in the brain and biological fluids in prion diseases​
    Diaz-Lucena, D.; Kruse, N.; Thüne, K.; Schmitz, M.; Villar-Piqué, A.; da Cunha, J. E. G. & Hermann, P. et al.​ (2021) 
    Acta Neuropathologica141(6) pp. 841​-859​.​ DOI: https://doi.org/10.1007/s00401-021-02296-1 
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  • 2021 Journal Article | 
    ​ ​Analyzing microglial phenotypes across neuropathologies: a practical guide​
    Schwabenland, M.; Brück, W.; Priller, J.; Stadelmann, C. ; Lassmann, H. & Prinz, M.​ (2021) 
    Acta Neuropathologica142(6) pp. 923​-936​.​ DOI: https://doi.org/10.1007/s00401-021-02370-8 
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  • 2021 Journal Article | Overview | 
    ​ ​Lipids, lysosomes and mitochondria: insights into Lewy body formation from rare monogenic disorders​
    Erskine, D.; Koss, D.; Korolchuk, V. I.; Outeiro, T. F. ; Attems, J. & McKeith, I.​ (2021) 
    Acta Neuropathologica141(4) pp. 511​-526​.​ DOI: https://doi.org/10.1007/s00401-021-02266-7 
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  • 2021 Journal Article | Editorial Contribution (Editorial, Introduction, Epilogue) | 
    ​ ​Emerging concepts in synucleinopathies​
    Outeiro, T. F. ​ (2021) 
    Acta Neuropathologica141(4) pp. 469​-470​.​ DOI: https://doi.org/10.1007/s00401-021-02290-7 
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  • 2020 Journal Article | 
    ​ ​Antibody signatures in patients with histopathologically defined multiple sclerosis patterns​
    Stork, L.; Ellenberger, D.; Ruprecht, K.; Reindl, M.; Beißbarth, T. ; Friede, T. & Kümpfel, T. et al.​ (2020) 
    Acta Neuropathologica139(3) pp. 547​-564​.​ DOI: https://doi.org/10.1007/s00401-019-02120-x 
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  • 2020 Journal Article
    ​ ​HIF-1α is involved in blood–brain barrier dysfunction and paracellular migration of bacteria in pneumococcal meningitis​
    Devraj, G.; Guérit, S.; Seele, J.; Spitzer, D.; Macas, J.; Khel, M. I. & Heidemann, R. et al.​ (2020) 
    Acta Neuropathologica140(2) pp. 183​-208​.​ DOI: https://doi.org/10.1007/s00401-020-02174-2 
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  • 2020 Journal Article
    ​ ​Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation​
    Castel, D.; Kergrohen, T.; Tauziède-Espariat, A.; Mackay, A.; Ghermaoui, S.; Lechapt, E. & Pfister, S. M. et al.​ (2020) 
    Acta Neuropathologica139(6) pp. 1109​-1113​.​ DOI: https://doi.org/10.1007/s00401-020-02142-w 
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  • 2020 Journal Article
    ​ ​Infratentorial IDH-mutant astrocytoma is a distinct subtype​
    Banan, R.; Stichel, D.; Bleck, A.; Hong, B.; Lehmann, U.; Suwala, A. & Reinhardt, A. et al.​ (2020) 
    Acta Neuropathologica140(4) pp. 569​-581​.​ DOI: https://doi.org/10.1007/s00401-020-02194-y 
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  • 2020 Journal Article | 
    ​ ​Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood–brain barrier​
    Hauptmann, J.; Johann, L.; Marini, F.; Kitic, M.; Colombo, E.; Mufazalov, I. A. & Krueger, M. et al.​ (2020) 
    Acta Neuropathologica140(4) pp. 549​-567​.​ DOI: https://doi.org/10.1007/s00401-020-02187-x 
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  • 2020 Journal Article | 
    ​ ​Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis​
    Suwala, A. K.; Stichel, D.; Schrimpf, D.; Kloor, M.; Wefers, A. K.; Reinhardt, A. & Maas, S. L. N. et al.​ (2020) 
    Acta Neuropathologica141(1) pp. 85​-100​.​ DOI: https://doi.org/10.1007/s00401-020-02243-6 
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  • 2020 Journal Article | 
    ​ ​PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment​
    Kleineidam, L.; Chouraki, V.; Próchnicki, T.; van der Lee, S. J.; Madrid-Márquez, L.; Wagner-Thelen, H. & Karaca, I. et al.​ (2020) 
    Acta Neuropathologica139(6) pp. 1025​-1044​.​ DOI: https://doi.org/10.1007/s00401-020-02138-6 
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  • 2020 Journal Article | 
    ​ ​SFPQ and Tau: critical factors contributing to rapid progression of Alzheimer’s disease​
    Younas, N. ; Zafar, S. ; Shafiq, M. ; Noor, A.; Siegert, A.; Arora, A. S.   & Galkin, A. et al.​ (2020) 
    Acta Neuropathologica140(3) pp. 317​-339​.​ DOI: https://doi.org/10.1007/s00401-020-02178-y 
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  • 2020 Journal Article | 
    ​ ​Inhibition of Bruton’s tyrosine kinase interferes with pathogenic B-cell development in inflammatory CNS demyelinating disease​
    Torke, S.; Pretzsch, R.; Häusler, D.; Haselmayer, P.; Grenningloh, R.; Boschert, U. & Brück, W.  et al.​ (2020) 
    Acta Neuropathologica140(4) pp. 535​-548​.​ DOI: https://doi.org/10.1007/s00401-020-02204-z 
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  • 2020 Journal Article | Research Paper | 
    ​ ​Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS​
    LaClair, K. D.; Zhou, Q.; Michaelsen, M.; Wefers, B.; Brill, M. S.; Janjic, A. & Rathkolb, B. et al.​ (2020) 
    Acta Neuropathologica140(2) pp. 121​-142​.​ DOI: https://doi.org/10.1007/s00401-020-02176-0 
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  • 2020 Journal Article | Research Paper | 
    ​ ​MOG-expressing teratoma followed by MOG-IgG-positive optic neuritis​
    Wildemann, B.; Jarius, S.; Franz, J.; Ruprecht, K.; Reindl, M. & Stadelmann, C. ​ (2020) 
    Acta Neuropathologica141(1) pp. 127​-131​.​ DOI: https://doi.org/10.1007/s00401-020-02236-5 
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  • 2019 Journal Article
    ​ ​Necrosome complex detected in granulovacuolar degeneration is associated with neuronal loss in Alzheimer’s disease​
    Koper, M. J.; Van Schoor, E.; Ospitalieri, S.; Vandenberghe, R.; Vandenbulcke, M.; von Arnim, C. A. F.   & Tousseyn, T. et al.​ (2019) 
    Acta Neuropathologica139(3) pp. 463​-484​.​ DOI: https://doi.org/10.1007/s00401-019-02103-y 
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  • 2019 Journal Article | Research Paper | 
    ​ ​Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson’s disease model​
    Wegrzynowicz, M.; Bar-On, D.; Calo’, L.; Anichtchik, O.; Iovino, M.; Xia, J. & Ryazanov, S.  et al.​ (2019) 
    Acta Neuropathologica138(4) pp. 575​-595​.​ DOI: https://doi.org/10.1007/s00401-019-02023-x 
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  • 2019 Journal Article | Erratum | 
    ​ ​Correction to: Ketogenic diet ameliorates axonal defects and promotes myelination in Pelizaeus–Merzbacher disease​
    Stumpf, S. K.; Berghoff, S. A.; Trevisiol, A.; Spieth, L.; Düking, T.; Schneider, L. V. & Schlaphoff, L. et al.​ (2019) 
    Acta Neuropathologica138(4) pp. 673​-674​.​ DOI: https://doi.org/10.1007/s00401-019-02064-2 
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  • 2019 Journal Article | 
    ​ ​Ketogenic diet ameliorates axonal defects and promotes myelination in Pelizaeus-Merzbacher disease​
    Stumpf, S. K.; Berghoff, S. A.; Trevisiol, A. ; Spieth, L.; Düking, T.; Schneider, L. V. & Schlaphoff, L. et al.​ (2019) 
    Acta Neuropathologica138(1) pp. 147​-161​.​ DOI: https://doi.org/10.1007/s00401-019-01985-2 
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  • 2018 Journal Article
    ​ ​BACE1 inhibition more effectively suppresses initiation than progression of β-amyloid pathology​
    Peters, F.; Salihoglu, H.; Rodrigues, E. ; Herzog, E.; Blume, T.; Filser, S. & Dorostkar, M. et al.​ (2018) 
    Acta Neuropathologica135(5) pp. 695​-710​.​ DOI: https://doi.org/10.1007/s00401-017-1804-9 
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  • 2018 Journal Article
    ​ ​The metalloprotease ADAMTS4 generates N-truncated Aβ4–x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer’s disease​
    Walter, S.; Jumpertz, T.; Hüttenrauch, M. ; Ogorek, I.; Gerber, H.; Storck, S. E. & Zampar, S. et al.​ (2018) 
    Acta Neuropathologica137(2) pp. 239​-257​.​ DOI: https://doi.org/10.1007/s00401-018-1929-5 
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  • 2018 Journal Article
    ​ ​Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features​
    Deng, M. Y.; Sill, M.; Chiang, J.; Schittenhelm, J.; Ebinger, M.; Schuhmann, M. U. & Monoranu, C.-M. et al.​ (2018) 
    Acta Neuropathologica136(2) pp. 239​-253​.​ DOI: https://doi.org/10.1007/s00401-018-1865-4 
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  • 2018 Journal Article | Erratum
    ​ ​Correction to: A suggestion to introduce the diagnosis of “diffuse midline glioma of the pons, H3 K27 wildtype (WHO grade IV)”​
    von Bueren, A. O. ; Karremann, M.; Gielen, G. H.; Benesch, M.; Fouladi, M.; van Vuurden, D. G. & Veldhuijzen van Zanten, S. E. M. et al.​ (2018) 
    Acta Neuropathologica136(4) pp. 661​-661​.​ DOI: https://doi.org/10.1007/s00401-018-1896-x 
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  • 2018 Journal Article
    ​ ​A suggestion to introduce the diagnosis of “diffuse midline glioma of the pons, H3 K27 wildtype (WHO grade IV)”​
    von Bueren, A. O. ; Karremann, M.; Gielen, G. H.; Benesch, M.; Fouladi, M.; van Vuurden, D. G. & van Zanten, S. E. M. V. et al.​ (2018) 
    Acta Neuropathologica136(1) pp. 171​-173​.​ DOI: https://doi.org/10.1007/s00401-018-1863-6 
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  • 2017 Journal Article
    ​ ​H3-/IDH-wild type pediatric glioblastoma is comprised of molecularly and prognostically distinct subtypes with associated oncogenic drivers​
    Korshunov, A.; Schrimpf, D.; Ryzhova, M.; Sturm, D.; Chavez, L.; Hovestadt, V. & Sharma, T. et al.​ (2017) 
    Acta Neuropathologica134(3) pp. 507​-516​.​ DOI: https://doi.org/10.1007/s00401-017-1710-1 
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  • 2017 Journal Article
    ​ ​Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination​
    Syed, Y. A.; Zhao, C.; Mahad, D.; Möbius, W. ; Altmann, F.; Foss, F. & Gonzalez, G. A. et al.​ (2017) 
    Acta Neuropathologica134(1) pp. 167​-168​.​ DOI: https://doi.org/10.1007/s00401-017-1712-z 
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  • 2017 Journal Article
    ​ ​An updated histological classification system for multiple sclerosis lesions​
    Kuhlmann, T.; Ludwin, S.; Prat, A.; Antel, J. P.; Brueck, W. & Lassmann, H.​ (2017) 
    Acta Neuropathologica133(1) pp. 13​-24​.​ DOI: https://doi.org/10.1007/s00401-016-1653-y 
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  • 2017 Journal Article | 
    ​ ​Pathogenic implications of distinct patterns of iron and zinc in chronic MS lesions​
    Popescu, B. F. G.; Frischer, J. M.; Webb, S. M.; Tham, M.; Adiele, R. C.; Robinson, C. A. & Fitz-Gibbon, P. D. et al.​ (2017) 
    Acta Neuropathologica134(1) pp. 45​-64​.​ DOI: https://doi.org/10.1007/s00401-017-1696-8 
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  • 2017 Journal Article | Research Paper
    ​ ​Identification of T cell target antigens in glioblastoma stem-like cells using an integrated proteomics-based approach in patient specimens​
    Rapp, C.; Warta, R.; Stamova, S.; Nowrouzi, A.; Geisenberger, C.; Gal, Z. & Roesch, S. et al.​ (2017) 
    Acta Neuropathologica134(2) pp. 297​-316​.​ DOI: https://doi.org/10.1007/s00401-017-1702-1 
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  • 2017 Journal Article | 
    ​ ​Differential contribution of immune effector mechanisms to cortical demyelination in multiple sclerosis​
    Lagumersindez-Denis, N.; Wrzos, C.; Mack, M.; Winkler, A.; van der Meer, F.; Reinert, M.-C. & Hollasch, H.  et al.​ (2017) 
    Acta Neuropathologica134(1) pp. 15​-34​.​ DOI: https://doi.org/10.1007/s00401-017-1706-x 
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  • 2016 Journal Article | 
    ​ ​Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination (vol 131, pg 281, 2016)​
    Syed, Y. A.; Zhao, C.; Mahad, D.; Möbius, W. ; Altmann, F.; Foss, F. & Gonzalez, G. A. et al.​ (2016) 
    Acta Neuropathologica132(1).​ DOI: https://doi.org/10.1007/s00401-016-1578-5 
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  • 2016 Journal Article | 
    ​ ​Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination​
    Syed, Y. A.; Zhao, C.; Mahad, D.; Möbius, W. ; Altmann, F.; Foss, F. & Sentuerk, A. et al.​ (2016) 
    Acta Neuropathologica131(2) pp. 281​-298​.​ DOI: https://doi.org/10.1007/s00401-015-1521-1 
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  • 2016 Review | 
    ​ ​Vascular, glial, and lymphatic immune gateways of the central nervous system​
    Engelhardt, B.; Carare, R. O.; Bechmann, I.; Fluegel, A.; Laman, J. D.& Weller, R. O.​ (2016)
    Acta Neuropathologica, 132​(3) pp. 317​-338​.​
    Springer. DOI: https://doi.org/10.1007/s00401-016-1606-5 
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  • 2016 Journal Article | Letter Note
    ​ ​Commentary on "Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes"​
    Jansen, M. H. A.; van Zanten, S. V.; Heymans, M. W.; Hargrave, D.; Kramm, C. M. & van Vuurden, D. G.​ (2016) 
    Acta Neuropathologica131(5) pp. 793​-794​.​ DOI: https://doi.org/10.1007/s00401-016-1567-8 
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  • 2016 Journal Article | 
    ​ ​Phosphorylation of the amyloid beta-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity​
    Kumar, S.; Wirths, O. ; Stueber, K.; Wunderlich, P.; Koch, P.; Theil, S. & Rezaei-Ghaleh, N. et al.​ (2016) 
    Acta Neuropathologica131(4) pp. 525​-537​.​ DOI: https://doi.org/10.1007/s00401-016-1546-0 
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  • 2016 Journal Article
    ​ ​CSF biomarkers associated with disease heterogeneity in early Parkinson's disease: the Parkinson's Progression Markers Initiative study​
    Kang, J.-H.; Mollenhauer, B.; Coffey, C. S.; Toledo, J. B.; Weintraub, D.; Galasko, D. R. & Irwin, D. J. et al.​ (2016) 
    Acta Neuropathologica131(6) pp. 935​-949​.​ DOI: https://doi.org/10.1007/s00401-016-1552-2 
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  • 2016 Journal Article | 
    ​ ​Myelin-reactive antibodies initiate T cell-mediated CNS autoimmune disease by opsonization of endogenous antigen​
    Kinzel, S.; Lehmann-Horn, K.; Torke, S.; Haeusler, D.; Winkler, A.; Stadelmann, C.   & Payne, N. L. et al.​ (2016) 
    Acta Neuropathologica132(1) pp. 43​-58​.​ DOI: https://doi.org/10.1007/s00401-016-1559-8 
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  • 2015 Journal Article | Research Paper
    ​ ​Molecular profiling of long-term survivors identifies a subgroup of glioblastoma characterized by chromosome 19/20 co-gain​
    Geisenberger, C.; Mock, A.; Warta, R.; Rapp, C.; Schwager, C.; Korshunov, A. & Nied, A.-K. et al.​ (2015) 
    Acta Neuropathologica130(3) pp. 419​-434​.​ DOI: https://doi.org/10.1007/s00401-015-1427-y 
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  • 2015 Journal Article
    ​ ​Abeta targets of the biosimilar antibodies of Bapineuzumab, Crenezumab, Solanezumab in comparison to an antibody against N-truncated Abeta in sporadic Alzheimer disease cases and mouse models​
    Bouter, Y. ; Noguerola, J. S. L.; Tucholla, P.; Crespi, G. A. N.; Parker, M. W.; Wiltfang, J.   & Miles, L. A. et al.​ (2015) 
    Acta Neuropathologica130(5) pp. 713​-729​.​ DOI: https://doi.org/10.1007/s00401-015-1489-x 
    Details  DOI 
  • 2015 Journal Article | 
    ​ ​Cell type-specific Nrf2 expression in multiple sclerosis lesions​
    Licht-Mayer, S.; Wimmer, I.; Traffehn, S.; Metz, I.; Brueck, W.; Bauer, J. & Bradl, M. et al.​ (2015) 
    Acta Neuropathologica130(2) pp. 263​-277​.​ DOI: https://doi.org/10.1007/s00401-015-1452-x 
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  • 2015 Journal Article | 
    ​ ​Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies​
    Wagner, J. ; Krauss, S.; Shi, S.; Ryazanov, S. ; Steffen, J.; Miklitz, C. & Leonov, A.  et al.​ (2015) 
    Acta Neuropathologica130(5) pp. 619​-631​.​ DOI: https://doi.org/10.1007/s00401-015-1483-3 
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  • 2015 Journal Article
    ​ ​Microglia inflict delayed brain injury after subarachnoid hemorrhage​
    Schneider, U. C.; Davids, A.-M.; Brandenburg, S.; Mueller, A.; Elke, A.; Magrini, S. & Atangana, E. et al.​ (2015) 
    Acta Neuropathologica130(2) pp. 215​-231​.​ DOI: https://doi.org/10.1007/s00401-015-1440-1 
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  • 2015 Journal Article | Research Paper | 
    ​ ​Extracellular vesicle sorting of alpha-Synuclein is regulated by sumoylation​
    Kunadt, M.; Eckermann, K.; Stuendl, A.; Gong, J.; Russo, B.; Strauss, K. & Rai, S. et al.​ (2015) 
    Acta Neuropathologica129(5) pp. 695​-713​.​ DOI: https://doi.org/10.1007/s00401-015-1408-1 
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  • 2015 Journal Article | Letter Note
    ​ ​High CCR5 expression in natalizumab-associated progressive multifocal leukoencephalopathy immune reconstitution inflammatory syndrome supports treatment with the CCR5 inhibitor maraviroc​
    Stork, L.; Brueck, W.; Bar-Or, A. & Metz, I.​ (2015) 
    Acta Neuropathologica129(3) pp. 467​-468​.​ DOI: https://doi.org/10.1007/s00401-015-1391-6 
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  • 2014 Review | 
    ​ ​Focusing the amyloid cascade hypothesis on N-truncated Abeta peptides as drug targets against Alzheimer's disease​
    Bayer, T. A.& Wirths, O.​ (2014)
    Acta Neuropathologica, 127​(6) pp. 787​-801​.​
    Springer. DOI: https://doi.org/10.1007/s00401-014-1287-x 
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  • 2014 Journal Article
    ​ ​Early loss of oligodendrocytes in human and experimental neuromyelitis optica lesions​
    Wrzos, C.; Winkler, A.; Metz, I.; Kayser, D. M.; Thal, D. R.; Wegner, C. & Brueck, W. et al.​ (2014) 
    Acta Neuropathologica127(4) pp. 523​-538​.​ DOI: https://doi.org/10.1007/s00401-013-1220-8 
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  • 2014 Journal Article | Letter Note
    ​ ​Subgroup-specific localization of human medulloblastoma based on pre-operative MRI​
    Wefers, A. K.; Warmuth-Metz, M.; Poeschl, J.; von Bueren, A. O.; Monoranu, C.-M.; Seelos, K. & Peraud, A. et al.​ (2014) 
    Acta Neuropathologica127(6) pp. 931​-933​.​ DOI: https://doi.org/10.1007/s00401-014-1271-5 
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  • 2014 Journal Article | 
    ​ ​Prognostic significance of clinical, histopathological, and molecular characteristics of medulloblastomas in the prospective HIT2000 multicenter clinical trial cohort​
    Pietsch, T.; Schmidt, R.; Remke, M.; Korshunov, A.; Hovestadt, V.; Jones, D. T. W. & Felsberg, J. et al.​ (2014) 
    Acta Neuropathologica128(1) pp. 137​-149​.​ DOI: https://doi.org/10.1007/s00401-014-1276-0 
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  • 2014 Journal Article | 
    ​ ​Oligodendroglia in cortical multiple sclerosis lesions decrease with disease progression, but regenerate after repeated experimental demyelination​
    Rodriguez, E. G.; Wegner, C.; Kreutzfeldt, M.; Neid, K.; Thal, D. R.; Juergens, T. & Brueck, W. et al.​ (2014) 
    Acta Neuropathologica128(2) pp. 231​-246​.​ DOI: https://doi.org/10.1007/s00401-014-1260-8 
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  • 2014 Journal Article | Letter Note | 
    ​ ​The oligomer modulator anle138b inhibits disease progression in a Parkinson mouse model even with treatment started after disease onset​
    Levin, J.; Schmidt, F.; Boehm, C.; Prix, C.; Boetzel, K.; Ryazanov, S.   & Leonov, A.  et al.​ (2014) 
    Acta Neuropathologica127(5) pp. 779​-780​.​ DOI: https://doi.org/10.1007/s00401-014-1265-3 
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  • 2014 Review | 
    ​ ​Is there a risk of prion-like disease transmission by Alzheimer- or Parkinson-associated protein particles?​
    Beekes, M.; Thomzig, A.; Schulz-Schaeffer, W. J.& Burger, R.​ (2014)
    Acta Neuropathologica, 128​(4) pp. 463​-476​.​
    Springer. DOI: https://doi.org/10.1007/s00401-014-1324-9 
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  • 2014 Journal Article
    ​ ​Chemokine-mediated redirection of T cells constitutes a critical mechanism of glucocorticoid therapy in autoimmune CNS responses​
    Schweingruber, N.; Fischer, H. J.; Fischer, L.; van den Brandt, J.; Karabinskaya, A.; Labi, V. & Villunger, A. et al.​ (2014) 
    Acta Neuropathologica127(5) pp. 713​-729​.​ DOI: https://doi.org/10.1007/s00401-014-1248-4 
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  • 2013 Journal Article | 
    ​ ​N-truncated amyloid beta (A beta) 4-42 forms stable aggregates and induces acute and long-lasting behavioral deficits​
    Bouter, Y.; Dietrich, K.; Wittnam, J. L.; Rezaei-Ghaleh, N.; Pillot, T.; Papot-Couturier, S. & Lefebvre, T. et al.​ (2013) 
    Acta Neuropathologica126(2) pp. 189​-205​.​ DOI: https://doi.org/10.1007/s00401-013-1129-2 
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  • 2013 Journal Article
    ​ ​Early intraneuronal accumulation and increased aggregation of phosphorylated Abeta in a mouse model of Alzheimer's disease​
    Kumar, S.; Wirths, O.; Theil, S.; Gerth, J.; Bayer, T. A. & Walter, J.​ (2013) 
    Acta Neuropathologica125(5) pp. 699​-709​.​ DOI: https://doi.org/10.1007/s00401-013-1107-8 
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  • 2013 Journal Article | 
    ​ ​Microglial nodules in early multiple sclerosis white matter are associated with degenerating axons​
    Singh, S.; Metz, I.; Amor, S.; van der Valk, P.; Stadelmann, C.   & Brueck, W.​ (2013) 
    Acta Neuropathologica125(4) pp. 595​-608​.​ DOI: https://doi.org/10.1007/s00401-013-1082-0 
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  • 2013 Journal Article | Research Paper | 
    ​ ​Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease​
    Wagner, J. ; Ryazanov, S. ; Leonov, A. ; Levin, J.; Shi, S.; Schmidt, F. & Prix, C. et al.​ (2013) 
    Acta Neuropathologica125(6) pp. 795​-813​.​ DOI: https://doi.org/10.1007/s00401-013-1114-9 
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  • 2013 Journal Article | Research Paper
    ​ ​MicroRNA-124 protects against focal cerebral ischemia via mechanisms involving Usp14-dependent REST degradation​
    Doeppner, T. R. ; Doehring, M.; Bretschneider, E. ; Zechariah, A.; Kaltwasser, B.; Müller, B. & Koch, J. C.  et al.​ (2013) 
    Acta Neuropathologica126(2) pp. 251​-265​.​ DOI: https://doi.org/10.1007/s00401-013-1142-5 
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  • 2012 Journal Article | 
    ​ ​Courage, luck and patience: in celebration of the 80th birthday of Georg W. Kreutzberg​
    Graeber, M. B.; Banati, R. B.; Fluegel, A.; Streit, W. J. & Tetzlaff, W.​ (2012) 
    Acta Neuropathologica124(4) pp. 593​-598​.​ DOI: https://doi.org/10.1007/s00401-012-1033-1 
    Details  DOI  PMID  PMC  WoS 
  • 2012 Journal Article | 
    ​ ​Reduced astrocytic NF-kappa B activation by laquinimod protects from cuprizone-induced demyelination​
    Brück, W. ; Pfoertner, R.; Pham, T.; Zhang, J.; Hayardeny, L.; Piryatinsky, V. & Hanisch, U.-K.  et al.​ (2012) 
    Acta Neuropathologica124(3) pp. 411​-424​.​ DOI: https://doi.org/10.1007/s00401-012-1009-1 
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  • 2012 Journal Article | 
    ​ ​Central nervous system rather than immune cell-derived BDNF mediates axonal protective effects early in autoimmune demyelination​
    Lee, D.-H.; Geyer, E.; Flach, A.-C. ; Jung, K.; Gold, R.; Fluegel, A. & Linker, R. A. et al.​ (2012) 
    Acta Neuropathologica123(2) pp. 247​-258​.​ DOI: https://doi.org/10.1007/s00401-011-0890-3 
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  • 2012 Journal Article | 
    ​ ​Pathology of immune reconstitution inflammatory syndrome in multiple sclerosis with natalizumab-associated progressive multifocal leukoencephalopathy​
    Metz, I.; Radue, E.-W.; Oterino, A.; Kuempfel, T.; Wiendl, H.; Schippling, S. & Kuhle, J. et al.​ (2012) 
    Acta Neuropathologica123(2) pp. 235​-245​.​ DOI: https://doi.org/10.1007/s00401-011-0900-5 
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  • 2012 Journal Article | Research Paper | 
    ​ ​Aggregation of αSynuclein promotes progressive in vivo neurotoxicity in adult rat dopaminergic neurons​
    Taschenberger, G. ; Garrido, M.; Tereshchenko, Y. ; Baehr, M. ; Zweckstetter, M.   & Kügler, S. ​ (2012) 
    Acta Neuropathologica123(5) pp. 671​-683​.​ DOI: https://doi.org/10.1007/s00401-011-0926-8 
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  • 2011 Journal Article | Research Paper | 
    ​ ​Glutathione depletion and overproduction both initiate degeneration of nigral dopaminergic neurons​
    Garrido, M.; Tereshchenko, Y. ; Zhevtsova, Z.; Taschenberger, G. ; Bähr, M.   & Kügler, S. ​ (2011) 
    Acta Neuropathologica121(4) pp. 475​-485​.​ DOI: https://doi.org/10.1007/s00401-010-0791-x 
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  • 2011 Journal Article | Research Paper | 
    ​ ​Enhancement of endogenous neurogenesis in ephrin-B3 deficient mice after transient focal cerebral ischemia​
    Doeppner, T. R. ; Bretschneider, E. ; Doehring, M.; Segura, I.; Sentürk, A.; Acker-Palmer, A. & Hasan, M. R. et al.​ (2011) 
    Acta Neuropathologica122(4) pp. 429​-442​.​ DOI: https://doi.org/10.1007/s00401-011-0856-5 
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  • 2010 Review | 
    ​ ​The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson's disease and Parkinson's disease dementia​
    Schulz-Schaeffer, W. J.​ (2010)
    Acta Neuropathologica, 120​(2) pp. 131​-143​.​
    Springer. DOI: https://doi.org/10.1007/s00401-010-0711-0 
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  • 2010 Journal Article | 
    ​ ​Accumulation of intraneuronal A beta correlates with ApoE4 genotype​
    Christensen, D. Z.; Schneider-Axmann, T.; Lucassen, P. J.; Bayer, T. A. & Wirths, O.​ (2010) 
    Acta Neuropathologica119(5) pp. 555​-566​.​ DOI: https://doi.org/10.1007/s00401-010-0666-1 
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  • 2009 Conference Abstract
    ​ ​Astroglia Pathology in Early Multiple Sclerosis​
    Koenig, F. B.; Loescher, A.; Metz, I.; Mueller, S.; Lucchinetti, C. F. & Brueck, W.​ (2009)
    Acta Neuropathologica118(3) ​54th Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Dusseldorf, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2009 Conference Abstract
    ​ ​Therapeutic treatment with Laquinimod reduces inflammation, demyelination and axonal damage in experimental autoimmune encephalomyelitis​
    Wegner, C.; Stadelmann, C.   & Brueck, W.​ (2009)
    Acta Neuropathologica118(3) ​54th Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Dusseldorf, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2009 Conference Abstract
    ​ ​The Functional Role of Puma and Noxa in Oligodendroglial Cell Death​
    Luerbke, A.; Hesse, A. R.; Salinas-Riester, G. & Kuhlmann, T.​ (2009)
    Acta Neuropathologica118(3) ​54th Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Dusseldorf, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2009 Conference Abstract
    ​ ​Brain-specific I kappa B kinase 2 is crucial for demyelination of the CNS but dispensable for myelin formation and repair.​
    Zeller, N.; Raasch, J.; van Loo, G.; Merkler, D.; Mildner, A.; Erny, D. & Knobeloch, K.-P. et al.​ (2009)
    Acta Neuropathologica118(3) ​54th Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Dusseldorf, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2009 Conference Abstract
    ​ ​Alzheimer's Disease pathology is not sufficient for CCR2(+) bone marrow engraftment in the CNS​
    Mildner, A.; Schlevogt, B.; Kierdorf, K.; Boettcher, C.; Kummer, M. P.; Wirths, O. & Henneka, M. et al.​ (2009)
    Acta Neuropathologica118(3) ​54th Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Dusseldorf, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2009 Conference Abstract
    ​ ​Synaptic mechanisms of alpha-synuclein aggregates in neurodegeneration​
    Schulz-Schaeffer, W. J.​ (2009)
    Acta Neuropathologica118(3) ​54th Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Dusseldorf, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2009 Conference Abstract
    ​ ​Increased axonal damage in p75(NTR)-knockout mice after induction of experimental autoimmune encephalomyelitis by adoptive transfer​
    Dallenga, T.; Bittner, A.; Jaeger, W.; Vollmar, P.; Oertel, W. H.; Sommer, N. & Moeller, J. C. et al.​ (2009)
    Acta Neuropathologica118(3) ​54th Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Dusseldorf, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2009 Conference Abstract
    ​ ​Selective astrocyte depletion in the mouse brain​
    Wrzos, C.; Bennett, J. L.; Brueck, W.; Nessler, S. & Stadelmann, C. ​ (2009)
    Acta Neuropathologica118(3) ​54th Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Dusseldorf, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2009 Journal Article | 
    ​ ​APP/PS1KI bigenic mice develop early synaptic deficits and hippocampus atrophy​
    Breyhan, H.; Wirths, O.; Duan, K.; Marcello, A.; Rettig, J. & Bayer, T. A.​ (2009) 
    Acta Neuropathologica117(6) pp. 677​-685​.​ DOI: https://doi.org/10.1007/s00401-009-0539-7 
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  • 2009 Journal Article | 
    ​ ​Incidence and spectrum of sporadic Creutzfeldt-Jakob disease variants with mixed phenotype and co-occurrence of PrPSc types: an updated classification​
    Parchi, P.; Strammiello, R.; Notari, S.; Giese, A.; Langeveld, J. P. M.; Ladogana, A. & Zerr, I. et al.​ (2009) 
    Acta Neuropathologica118(5) pp. 659​-671​.​ DOI: https://doi.org/10.1007/s00401-009-0585-1 
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  • 2009 Journal Article | 
    ​ ​Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model​
    Wirths, O.; Breyhan, H.; Cynis, H.; Schilling, S.; Demuth, H.-U. & Bayer, T. A.​ (2009) 
    Acta Neuropathologica118(4) pp. 487​-496​.​ DOI: https://doi.org/10.1007/s00401-009-0557-5 
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  • 2009 Journal Article | 
    ​ ​Staging/typing of Lewy body related alpha-synuclein pathology: a study of the BrainNet Europe Consortium​
    Alafuzoff, I.; Ince, P. G.; Arzberger, T.; Al-Sarraj, S.; Bell, J. E.; Bodi, I. & Bogdanovic, N. et al.​ (2009) 
    Acta Neuropathologica117(6) pp. 635​-652​.​ DOI: https://doi.org/10.1007/s00401-009-0523-2 
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  • 2009 Journal Article | 
    ​ ​Increased neurogenesis after hypoxic-ischemic encephalopathy in humans is age related​
    Mattiesen, W. Mattiesen, Wulf-Rainer C.; Tauber, S. C.; Gerber, J.; Bunkowski, S.; Brueck, W. & Nau, R.​ (2009) 
    Acta Neuropathologica117(5) pp. 525​-534​.​ DOI: https://doi.org/10.1007/s00401-009-0509-0 
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  • 2009 Journal Article | 
    ​ ​Stereologic investigation of the posterior part of the hippocampus in schizophrenia​
    Schmitt, A.; Steyskal, C.; Bernstein, H.-G.; Schneider-Axmann, T.; Parlapani, E.; Schaeffer, E. L. & Gattaz, W. F. et al.​ (2009) 
    Acta Neuropathologica117(4) pp. 395​-407​.​ DOI: https://doi.org/10.1007/s00401-008-0430-y 
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  • 2009 Journal Article | 
    ​ ​Assessment of beta-amyloid deposits in human brain: a study of the BrainNet Europe Consortium​
    Alafuzoff, I.; Thal, D. R.; Arzberger, T.; Bogdanovic, N.; Al-Sarraj, S.; Bodi, I. & Boluda, S. et al.​ (2009) 
    Acta Neuropathologica117(3) pp. 309​-320​.​ DOI: https://doi.org/10.1007/s00401-009-0485-4 
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  • 2008 Conference Abstract
    ​ ​Effect of repeated inflammatory demyelination on intrinsic remyelination in the targeted cortical EAE model​
    Garea-Rodriguez, E.; Brueck, W.; Stadelmann, C.   & Merkler, D.​ (2008)
    Acta Neuropathologica116(3) ​53rd Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Wurzburg, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2008 Conference Abstract
    ​ ​Tryptophan levels as quality control on human postmortem brain tissue​
    Gruenblatt, E.; Monoranu, C.-M.; Apfelbacher, M.; Altenhofer, D.; Alafuzoff, I.; Ferrer, I. & Al-Saraj, S. et al.​ (2008)
    Acta Neuropathologica116(3) ​53rd Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Wurzburg, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2008 Conference Abstract
    ​ ​Erythropoietin receptor is expressed in meningiomas and is downregulated in tumor recurrences​
    Kuester, O.; Simon, P.; Mittelbronn, M.; Tabatabai, G.; Strik, H.; Dietz, K. & Roser, F. et al.​ (2008)
    Acta Neuropathologica116(3) pp. 349​-350. ​53rd Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Wurzburg, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2008 Conference Abstract
    ​ ​Immunization of cuprizone-treated mice leads to cerebral inflammatory pathology​
    Escher, A.; Nessler, S.; Vollmar, P.; Merkler, D.; Boretius, S.; Brueck, W. & Reichardt, H. et al.​ (2008)
    Acta Neuropathologica116(3) ​53rd Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Wurzburg, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2008 Journal Article | 
    ​ ​Shaken baby syndrome: re-examination of diffuse axonal injury as cause of death​
    Oehmichen, M.; Schleiss, D.; Pedal, I.; Saternus, K.-S.; Gerling, I. & Meissner, C.​ (2008) 
    Acta Neuropathologica116(3) pp. 317​-329​.​ DOI: https://doi.org/10.1007/s00401-008-0356-4 
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  • 2008 Review
    ​ ​Management of a twenty-first century brain bank: experience in the BrainNet Europe consortium​
    Bell, J. E.; Alafuzoff, I.; Al-Sarraj, S.; Arzberger, T.; Bogdanovic, N.; Budka, H.& Dexter, D. T. et al.​ (2008)
    Acta Neuropathologica, 115​(5) pp. 497​-507​.​
    Springer. DOI: https://doi.org/10.1007/s00401-008-0360-8 
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  • 2008 Journal Article
    ​ ​Inter-laboratory comparison of neuropathological assessments of beta-amyloid protein: a study of the BrainNet Europe consortium​
    Alafuzoff, I.; Pikkarainen, M.; Arzberger, T.; Thal, D. R.; Al-Sarraj, S.; Bell, J. E. & Bodi, I. et al.​ (2008) 
    Acta Neuropathologica115(5) pp. 533​-546​.​ DOI: https://doi.org/10.1007/s00401-008-0358-2 
    Details  DOI  PMID  PMC  WoS 
  • 2008 Review | 
    ​ ​Diagnosis of inflammatory demyelination in biopsy specimens: a practical approach​
    Kuhlmann, T.; Lassmann, H.& Brueck, W.​ (2008)
    Acta Neuropathologica, 115​(3) pp. 275​-287​.​
    Springer. DOI: https://doi.org/10.1007/s00401-007-0320-8 
    Details  DOI  PMID  PMC  WoS 
  • 2008 Journal Article | 
    ​ ​Transient intraneuronal A beta rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice​
    Christensen, D. Z.; Kraus, S. L.; Flohr, A.; Cotel, M.-C.; Wirths, O. & Bayer, T. A.​ (2008) 
    Acta Neuropathologica116(6) pp. 647​-655​.​ DOI: https://doi.org/10.1007/s00401-008-0451-6 
    Details  DOI  PMID  PMC  WoS 
  • 2007 Conference Abstract
    ​ ​Microglia in the adult brain arise from Ly-6 Chi monocytes only under defined host conditions​
    Mildner, A.; Schmidt, H.; Nitsche, M.; Merkler, D.; Hanisch, U.-K.; Mack, M. & Heikenwalder, M. et al.​ (2007)
    Acta Neuropathologica114(3) ​Joint Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy (DGNN)/Polish-Associatin-of-Neuropathologists​, Greifswald, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2007 Conference Abstract
    ​ ​Innate immunity mediated by the MyD88-independent pathway modulates CNS autoimmunity via type I interferon induction​
    Wolter, K.; Mildner, A.; Schmidt, H.; Prinz, M. R. & Brueck, W.​ (2007)
    Acta Neuropathologica114(3) ​Joint Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy (DGNN)/Polish-Associatin-of-Neuropathologists​, Greifswald, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2007 Conference Abstract
    ​ ​Diagnosis of inflammatory demyelination in biopsy specimens​
    Brueck, W.​ (2007)
    Acta Neuropathologica114(3) ​Joint Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy (DGNN)/Polish-Associatin-of-Neuropathologists​, Greifswald, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2007 Conference Abstract
    ​ ​The brain endogenous I kappa B kinase complex is crucially involved in demyelination but not myelin formation of the CNS​
    Raasch, J.; van Loo, G.; Mildner, A.; Merkler, D.; Brueck, W.; Pasparakis, M. & Prinz, M. R.​ (2007)
    Acta Neuropathologica114(3) ​Joint Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy (DGNN)/Polish-Associatin-of-Neuropathologists​, Greifswald, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2007 Conference Abstract
    ​ ​Macrophage activation patterns in active multiple sclerosis lesions​
    Koenig, F. B.; Fischer, I.; Guenther, A.; Metz, I.; Lucchinetti, C. F. & Brueck, W.​ (2007)
    Acta Neuropathologica114(3) ​Joint Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy (DGNN)/Polish-Associatin-of-Neuropathologists​, Greifswald, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2007 Journal Article
    ​ ​A novel subtype of Creutzfeldt-Jakob disease characterized by a small 6 kDa PrP fragment​
    Krebs, B.; Bader, B.; Klehmet, J.; Grasbon-Frodl, E.; Oertel, W. H.; Zerr, I. & Stricker, S. et al.​ (2007) 
    Acta Neuropathologica114(2) pp. 195​-199​.​ DOI: https://doi.org/10.1007/s00401-007-0242-5 
    Details  DOI  PMID  PMC  WoS 
  • 2006 Conference Abstract
    ​ ​Type 1 interferon receptor (IFNAR)-dependent modulation of myeloid cell activation determines the course of experimental autoimmune encephalomyelitis​
    Schmidt, H.; Detje, C. N.; Mildner, A.; Hanisch, U.-K.; Gold, R.; Becher, B. & Brueck, W. et al.​ (2006)
    Acta Neuropathologica112(3) ​51st Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Mannheim, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2006 Conference Abstract
    ​ ​Grey matter pathology induced by immunisation with a beta-Synuclein peptide​
    Escher, A.; Merkler, D.; Diem, R.; Brueck, W. & Stadelmann, C. ​ (2006)
    Acta Neuropathologica112(3) , Mannheim, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2006 Conference Abstract
    ​ ​Rapid resolution of inflammation and extensive remyelination in a focal cortical EAE model​
    Merkler, D.; Ernsting, T.; Kerschensteiner, M.; Brueck, W. & Stadelmann, C. ​ (2006)
    Acta Neuropathologica112(3) , Mannheim, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2006 Conference Abstract
    ​ ​Brain endogenous IkB kinase complex modulates course of demyelination​
    Raasch, J.; van Loo, G.; Mildner, A.; Merkler, D.; Brueck, W.; Pasparakis, M. & Prinz, M. R.​ (2006)
    Acta Neuropathologica112(3) ​51st Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Mannheim, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2006 Conference Abstract
    ​ ​Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis​
    Prinz, M. R.; Garbe, F.; Schmidt, H.; Mildner, A.; Gutcher, I.; Wolter, K. & Piesche, M. et al.​ (2006)
    Acta Neuropathologica112(3) ​51st Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Mannheim, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2006 Conference Abstract
    ​ ​Activation pattern of macrophages in inflammatory myopathies​
    Bergmann, M.; Klingebiel, S.; Rokamm, R.; Schwendemann, G.; Engelhardt, A.; Besinger, U. A. & Brueck, W.​ (2006)
    Acta Neuropathologica112(3) pp. 371​-372. ​51st Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Mannheim, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2006 Conference Abstract
    ​ ​The presence of the chemokine receptor CCR2 on specific myeloid cells determines the outcome of autoimmune encephalomyelitis​
    Mildner, A.; Schmidt, H.; Mack, M.; Brueck, W.; Priller, J. & Prinz, M. R.​ (2006)
    Acta Neuropathologica112(3) ​51st Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Mannheim, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2005 Conference Abstract
    ​ ​CCR2 expression on myeloid cells is sufficient for disease development in a mouse model of multiple sclerosis.​
    Mildner, A.; Schmidt, H.; Pruess, H.; Priller, J.; Bruck, W. W. & Prinz, M. R.​ (2005)
    Acta Neuropathologica110(3) ​50th Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Graz, AUSTRIA.
    New york​: Springer.
    Details  WoS 
  • 2005 Conference Abstract
    ​ ​Lack of Type 1 Interferon Receptor (IFNAR) leads to exacerbation of experimental autoimmune encephalomyelitis​
    Schmidt, H.; Mildner, A.; Hanisch, U.-K.; Bruck, W. W.; Kalinke, U. & Prinz, M. R.​ (2005)
    Acta Neuropathologica110(3) ​50th Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Graz, AUSTRIA.
    New york​: Springer.
    Details  WoS 
  • 2005 Conference Abstract
    ​ ​The interferon type I induced protease UBP43 is crucial for CNS myelination​
    Raasch, J.; Horak, I.; Bruck, W. W.; Knobeloch, K. P. & Prinz, M. R.​ (2005)
    Acta Neuropathologica110(3) ​50th Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Graz, AUSTRIA.
    New york​: Springer.
    Details  WoS 
  • 2005 Conference Abstract
    ​ ​Extensive cortical demyelination in MOG-induced EAE in the common marmoset​
    Merkler, D.; Schmelting, B.; Czeh, B.; Fuchs, E.; Bruck, W. W. & Stadelmann, C. ​ (2005)
    Acta Neuropathologica110(3) ​50th Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Graz, AUSTRIA.
    New york​: Springer.
    Details  WoS 
  • 2005 Conference Abstract
    ​ ​Regression of synapses in the cerebellar dentate nucleus of patients with multiple sclerosis​
    Albert, M.; Antel, J. P.; Prineas, J. A.; Palkovits, M. & Wolff, J. R.​ (2005)
    Acta Neuropathologica110(3) ​50th Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Graz, AUSTRIA.
    New york​: Springer.
    Details  WoS 
  • 2005 Conference Abstract
    ​ ​Innate Immunity mediated by CNS-resident cells modulates pathogenicity in an animal model of multiple sclerosis​
    Prinz, M. R.; Garbe, F.; Schmidt, H.; Mildner, A.; Gutcher, I.; Piesche, M. & Schroers, R. et al.​ (2005)
    Acta Neuropathologica110(3) ​50th Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Graz, AUSTRIA.
    New york​: Springer.
    Details  WoS 
  • 2005 Conference Abstract
    ​ ​Differential expression of several S100 proteins during experimental autoimmune encephalomyelitis​
    Wolter, K.; Bruck, W. W.; Fritz, G. & Prinz, M. R.​ (2005)
    Acta Neuropathologica110(3) pp. 343​-344. ​50th Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Graz, AUSTRIA.
    New york​: Springer.
    Details  WoS 
  • 2005 Journal Article
    ​ ​Creutzfeldt-Jakob disease in a patient with an R208H mutation of the prion protein gene (PRNP) and a 17-kDa prion protein fragment​
    Roeber, S.; Krebs, B.; Neumann, M.; Windl, O.; Zerr, I.; Grasbon-Frodl, E.-M. & Kretzschmar, H. A.​ (2005) 
    Acta Neuropathologica109(4) pp. 443​-448​.​ DOI: https://doi.org/10.1007/s00401-004-0978-0 
    Details  DOI  PMID  PMC  WoS 
  • 2004 Conference Abstract
    ​ ​Stathmin as a modulator of remyelination in MS lesions?​
    Stadelmann, C. ; Liu, A. X.; Casaccia-Bonnefil, P. & Bruck, W. W.​ (2004)
    Acta Neuropathologica108(4) ​49th Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Cologne, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2004 Conference Abstract
    ​ ​Strong immunmodulatory effects of type 1 interferon receptor for the course of experimental autoimmune encephalomyelitis​
    Schmidt, H.; Bruck, W. W.; Kalinke, U. & Prinz, M. R.​ (2004)
    Acta Neuropathologica108(4) ​49th Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Cologne, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2004 Conference Abstract
    ​ ​Brain biopsies of multiple sclerosis lesions during the first clinical attack​
    Stoltenburg-Didinger, G.; Stadelmann, C. ; Beseler, A. & Altenkirch, H.​ (2004)
    Acta Neuropathologica108(4) ​49th Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Cologne, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2004 Conference Abstract
    ​ ​Brain-specific MyD88 modulates T cell encephalitogenecity during the effector phase of EAE​
    Prinz, M. R.; Garbe, F.; Pische, M.; Schroers, R.; Weiss, E.; Gutcher, I. & Bruck, W. W. et al.​ (2004)
    Acta Neuropathologica108(4) ​49th Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Cologne, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2004 Conference Abstract
    ​ ​Brain demyelination is crucially dependent on the I kappa B kinase complex in vivo​
    Prinz, M. R.; van Loo, G. & Pasparakis, M.​ (2004)
    Acta Neuropathologica108(4) ​49th Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Cologne, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2004 Conference Abstract
    ​ ​The microglia-activating potential of thrombin: Is the protease able to induce cyto- and chemokines?​
    Hanisch, U.-K.; van Rossum, D.; Gast, K.; Misselwitz, R.; Goldstein, G.; Koistinaho, J. & Moller, T.​ (2004)
    Acta Neuropathologica108(4) ​49th Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Cologne, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2004 Conference Abstract
    ​ ​Characterization of an immuno-histochemical marker of Wallerian degeneration​
    Roemer, S.; Maruschak, B.; Bruck, W. W. & Stadelmann, C. ​ (2004)
    Acta Neuropathologica108(4) ​49th Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Cologne, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2004 Conference Abstract
    ​ ​Correlation between magnetic resonance imaging and neuropatho-logical findings of demyelination and remyelination in an experimental animal model​
    Merkler, D.; Boretius, S.; Stadelmann, C. ; Ernsting, T.; Awn, N.; Michaelis, T. & Frahm, J. et al.​ (2004)
    Acta Neuropathologica108(4) ​49th Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Cologne, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2004 Conference Abstract
    ​ ​Extensive remyelination in frontal cortex in patients with long-standing multiple sclerosis​
    Albert, M.; Stadelmann, C. ; Antel, J. P. & Bruck, W. W.​ (2004)
    Acta Neuropathologica108(4) ​49th Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Cologne, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2004 Conference Abstract
    ​ ​Scrapie agent uses neural pathways for invasion of muscles​
    Wrede, A.; Thomzig, A.; Beekes, M. & Schulz-Schaeffer, W. J.​ (2004)
    Acta Neuropathologica108(4) ​49th Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Cologne, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2004 Conference Abstract
    ​ ​Expression of matrix metallo-proteinases and their inhibitors in medulloblastomas and their prognostic relevance​
    Krebs, B.; Ozen, O.; Hemmerlein, B.; Pekrun, A.; Kretzschmar, H. A. & Herms, J.​ (2004)
    Acta Neuropathologica108(4) ​49th Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy​, Cologne, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2004 Journal Article
    ​ ​Modulation of simian immunodeficiency virus neuropathology by dopaminergic drugs​
    Czub, S.; Czub, M.; Koutsilieri, E.; Sopper, S.; Villinger, F.; Müller, J. G. & Stahl-Hennig, C. et al.​ (2004) 
    Acta Neuropathologica107(3) pp. 216​-226​.​ DOI: https://doi.org/10.1007/s00401-003-0801-3 
    Details  DOI 
  • 2004 Journal Article
    ​ ​Expression of tyrosine kinases FAK and Pyk2 in 331 human astrocytomas​
    Gutenberg, A.; Bruck, W. W.; Buchfelder, M. & Ludwig, H.-C.​ (2004) 
    Acta Neuropathologica108(3) pp. 224​-230​.​ DOI: https://doi.org/10.1007/s00401-004-0886-3 
    Details  DOI  PMID  PMC  WoS 
  • 2004 Journal Article
    ​ ​Rimmed vacuoles in facioscapulohumeral muscular dystrophy: a unique ultrastructural feature​
    Neudecker, S.; Krasnianski, M.; Bahn, E. & Zierz, S.​ (2004) 
    Acta Neuropathologica108(3) pp. 257​-259​.​ DOI: https://doi.org/10.1007/s00401-004-0894-3 
    Details  DOI  PMID  PMC  WoS 
  • 2004 Journal Article | Research Paper
    ​ ​Rifampicin inhibits neurodegeneration in the optic nerve transection model in vivo and after 1-methyl-4-phenylpyridinium intoxication in vitro​
    Kilic, U.; Kilic, E. ; Lingor, P. ; Yulug, B. & Bähr, M. ​ (2004) 
    Acta Neuropathologica108(1) pp. 65​-68​.​ DOI: https://doi.org/10.1007/s00401-004-0867-6 
    Details  DOI  PMID  PMC  WoS 
  • 2003 Conference Abstract
    ​ ​Permanent axonal loss in EAE in WLDs mice occurs independently of Wallerian degeneration​
    Stadelmann, C. ; Siebert, H. & Bruck, W. W.​ (2003)
    Acta Neuropathologica106(4) ​48th Annual Meeting of the German-Society-for-Neuropathology-and-Neuroanatomy​, BERLIN, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2003 Conference Abstract
    ​ ​Significant contribution of bone marrow-derived microglia to brain pathology of murine scrapie​
    Prinz, M. R. & Priller, J.​ (2003)
    Acta Neuropathologica106(4) ​48th Annual Meeting of the German-Society-for-Neuropathology-and-Neuroanatomy​, BERLIN, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2003 Conference Abstract
    ​ ​Hippocampal synapse formation depends on hippocampal estrogen synthesis​
    Fester, L.; Kretz, O.; Brauckmann, S.; Zhao, S.; Ceranik, K.; Naumann, T. & Prange-Kiel, J. et al.​ (2003)
    Acta Neuropathologica106(4) ​48th Annual Meeting of the German-Society-for-Neuropathology-and-Neuroanatomy​, BERLIN, GERMANY.
    New york​: Springer.
    Details  WoS 
  • 2003 Journal Article
    ​ ​Molecular genetic diagnosis of a primary central nervous system T cell lymphoma​
    Harder, A.; Dudel, C.; Anagnostopoulos, I.; Hummel, M. & Bruck, W. W.​ (2003) 
    Acta Neuropathologica105(1) pp. 65​-68​.​ DOI: https://doi.org/10.1007/s00401-002-0619-4 
    Details  DOI  PMID  PMC  WoS 
  • 2002 Journal Article
    ​ ​Pre-embedding immunogold labeling of TUNEL stain enables evaluation of DNA strand breaks and ultrastructural alterations in individual cells of neuronal tissue​
    Barth, M.; Oulmi, Y.; Ehrenreich, H.   & Schilling, L.​ (2002) 
    Acta Neuropathologica104(6) pp. 621​-636​.​ DOI: https://doi.org/10.1007/s00401-002-0595-8 
    Details  DOI 
  • 2001 Journal Article | Research Paper
    ​ ​Enhancement of central nervous system pathology in early simian immunodeficiency virus infection by dopaminergic drugs​
    Czub, S.; Koutsilieri, E.; Sopper, S.; Czub, M.; Stahl-Hennig, C.; Müller, J. G. & Pedersen, V. et al.​ (2001) 
    Acta Neuropathologica101(2) pp. 85​-91​.​ DOI: https://doi.org/10.1007/s004010000313 
    Details  DOI  PMID  PMC 
  • 2001 Conference Abstract
    ​ ​Low incidence of SV40-like sequences in ependymal tumours​
    Scheil, S.; Reuther, F. J.; Löhler, J.; Herms, J.; Hugo, H. H.; Schindler, C. & Leithäuser, F. et al.​ (2001)
    Acta Neuropathologica102(5) 
    New york​: Springer.
    Details  WoS 
  • 2001 Conference Abstract
    ​ ​Evidence for local and systemic elimination of macrophages from the injured peripheral nervous system​
    Kuhlmann, T.; Bitsch, A.; Stadelmann, C. ; Siebert, H. & Bruck, W. W.​ (2001)
    Acta Neuropathologica102(5) 
    New york​: Springer.
    Details  WoS 
  • 2001 Journal Article
    ​ ​Erythropoietin and erythropoietin receptor in human ischemic/hypoxic brain​
    Siren, A. L.; Knerlich, F.; Poser, W.; Gleiter, C. H.; Bruck, W. W. & Ehrenreich, H.​ (2001) 
    Acta Neuropathologica101(3) pp. 271​-276​.​
    Details  PMID  PMC  WoS 
  • 2001 Journal Article
    ​ ​A mouse model of Streptococcus pneumoniae meningitis mimicking several features of human disease​
    Gerber, J.; Raivich, G.; Wellmer, A.; Noeske, C.; Kunst, T.; Werner, A. & Bruck, W. W. et al.​ (2001) 
    Acta Neuropathologica101(5) pp. 499​-508​.​
    Details  PMID  PMC  WoS 
  • 2001 Conference Abstract
    ​ ​Deficiency for the disintegrin/metalloprotease ADAM 10 causes disturbed alpha secretase activity and a notch deficiency like phenotype in mice​
    Hartmann, D.; de Strooper, B.; Serneels, L.; Craessaerts, K.; Herreman, A.; Annaert, W. & Lubke, T. et al.​ (2001)
    Acta Neuropathologica102(5) 
    New york​: Springer.
    Details  WoS 
  • 2000 Journal Article
    ​ ​Involvement of intercellular adhesion molecule-1 in myelin recognition by macrophages​
    Vougioukas, V. I.; Roeske, S. & Bruck, W. W.​ (2000) 
    Acta Neuropathologica99(6) pp. 673​-679​.​
    Details  PMID  PMC  WoS 
  • 2000 Journal Article
    ​ ​α-Synuclein accumulation in a case of neurodegeneration with brain iron accumulation type 1 (NBIA-1, formerly Hallervorden-Spatz syndrome) with widespread cortical and brainstem-type Lewy bodies​
    Neumann, M.; Adler, S.; Schlüter, O. M. ; Kremmer, E.; Benecke, R. & Kretzschmar, H. A.​ (2000) 
    Acta Neuropathologica100(5) pp. 568​-574​.​ DOI: https://doi.org/10.1007/s004010000224 
    Details  DOI 
  • 2000 Journal Article
    ​ ​Capillary changes in hippocampal CA1 and CA3 areas of the aging rhesus monkey​
    Keuker, J. I. H.; Luiten, P. G. M. & Fuchs, E.​ (2000) 
    Acta Neuropathologica100(6) pp. 665​-672​.​ DOI: https://doi.org/10.1007/s004010000227 
    Details  DOI 
  • 1999 Journal Article
    ​ ​Apoptosis of T lymphocytes in acute disseminated encephalomyelitis​
    Bauer, J.; Stadelmann, C. ; Bancher, C.; Jellinger, K. & Lassmann, H.​ (1999) 
    Acta Neuropathologica97(6) pp. 543​-546​.​ DOI: https://doi.org/10.1007/s004010051028 
    Details  DOI 
  • 1999 Journal Article
    ​ ​The N-methyl-D-aspartate receptor channel blocker amantadine does not cause histopathological alterations in human brain tissue​
    Kornhuber, J. ; Jellinger, K.; Wiltfang, J. ; Leblhuber, F. & Riederer, P.​ (1999) 
    Acta Neuropathologica98(1) pp. 85​-90​.​ DOI: https://doi.org/10.1007/s004010051054 
    Details  DOI  PMID  PMC 
  • 1997 Journal Article
    ​ ​Detection of JC virus by anti-VP1 immunohistochemistry in brains with progressive multifocal leukoencephalopathy​
    Jochum, W.; Weber, T.; Frye, S.; Hunsmann, G.; Lüke, W. & Aguzzi, A.​ (1997) 
    Acta Neuropathologica94(3) pp. 226​-231​.​ DOI: https://doi.org/10.1007/s004010050697 
    Details  DOI 

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