Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8(+) T Cell Responses
2016 | journal article. A publication with affiliation to the University of Göttingen.
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Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8(+) T Cell Responses
Loi, M.; Müller, A.; Steinbach, K.; Niven, J.; da Silva, R. B.; Paul, P. & Ligeon, L.-A. et al. (2016)
Cell Reports, 15(5) pp. 1076-1087. DOI: https://doi.org/10.1016/j.celrep.2016.04.002
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Details
- Authors
- Loi, Monica; Müller, Anne; Steinbach, Karin; Niven, Jennifer; da Silva, Rosa Barreira; Paul, Petra; Ligeon, Laure-Anne; Caruso, Assunta; Albrecht, Randy A.; Becker, Andrea C.; Annaheim, Nicolas; Nowag, Heike; Dengjel, Jorn; Garcia-Sastre, Adolfo; Merkler, Doron ; Münz, Christian; Gannage, Monique
- Abstract
- The macroautophagy machinery has been implicated in MHC class II restricted antigen presentation. Here, we report that this machinery assists in the internalization of MHC class I molecules. In the absence of the autophagy factors Atg5 and Atg7, MHC class I surface levels are elevated due to decreased endocytosis and degradation. Internalization of MHC class I molecules occurs less efficiently if AAK1 cannot be recruited via Atg8/LC3B. In the absence of Atg-dependent MHC class I internalization, dendritic cells stimulate CD8(+) T cell responses more efficiently in vitro and in vivo. During viral infections, lack of Atg5 results in enhanced influenzaand LCMV-specific CD8(+) T cell responses in vivo. Elevated influenza-specific CD8(+) T cell responses are associated with better immune control of this infection. Thus, the macroautophagy machinery orchestrates T cell immunity by supporting MHC class II but compromises MHC class I restricted antigen presentation.
- Issue Date
- 2016
- Journal
- Cell Reports
- ISSN
- 2211-1247