Clinicopathological Characteristics of RET Rearranged Lung Cancer in European Patients
2016 | journal article. A publication with affiliation to the University of Göttingen.
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Clinicopathological Characteristics of RET Rearranged Lung Cancer in European Patients
Michels, S.; Scheel, A. H. J.; Scheffler, M.; Schultheis, A. M.; Gautschi, O. P.; Aebersold, F. & Diebold, J. et al. (2016)
Journal of Thoracic Oncology, 11(1) pp. 122-+. DOI: https://doi.org/10.1016/j.jtho.2015.09.016
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Details
- Authors
- Michels, Sebastian; Scheel, Andreas Hans Joachim; Scheffler, Matthias; Schultheis, Anne Maria; Gautschi, Oliver Pascal; Aebersold, Franziska; Diebold, Joachim; Pall, Georg; Rothschild, Sacha; Bubendorf, Lukas; Hartmann, Wolfgang; Heukamp, Lukas Carl; Schildhaus, Hans-Ulrich ; Fassunke, Jana; Ihle, Michaela Angelika; Kuenstlinger, Helen; Heydt, Carina; Fischer, Rieke N.; Nogova, Lucia; Mattonet, Christian; Hein, Rebecca; Adams, Anne; Gerigk, Ulrich; Schulte, Wolfgang; Lueders, Heike; Grohe, Christian; Graeven, Ullrich; Mueller-Naendrup, Clemens; Draube, Andreas; Kambartel, Karl-Otto; Krüger, Stefan; Schulze-Olden, Susanne; Serke, Monika; Engel-Riedel, Walburga; Kaminsky, Britta; Randerath, Winfried J.; Merkelbach-Bruse, Sabine; Buettner, Reinhard; Wolf, Juergen
- Abstract
- Introduction: Rearrangements of RET are rare oncogenic events in patients with non-small cell lung cancer (NSCLC). While the characterization of Asian patients suggests a predominance of nonsmokers of young age in this genetically defined lung cancer subgroup, little is known about the characteristics of non-Asian patients. We present the results of an analysis of a European cohort of patients with RET rearranged NSCLC. Methods: Nine hundred ninety-seven patients with KRAS/EGFR/ALK wildtype lung adenocarcinomas were analyzed using fluorescence in situ hybridization for RET fusions. Tumor specimens were molecularly profiled and clinicopathological characteristics of the patients were collected. Results: Rearrangements of RET were identified in 22 patients, with a prevalence of 2.2% in the KRAS/EGFR/ALK wildtype subgroup. Co-occurring genetic aberrations were detected in 10 patients, and the majority had mutations in TP53. The median age at diagnosis was 62 years (range, 39-80 years; mean +/- SD, 61 +/- 11.7 years) with a higher proportion of men (59% versus 41%). There was only a slight predominance of nonsmokers (54.5%) compared to current or former smokers (45.5%). Conclusions: Patients with RET rearranged adenocarcinomas represent a rare and heterogeneous NSCLC sub-group. In some contrast to published data, we see a high prevalence of current and former smokers in our white RET cohort. The significance of co-occurring aberrations, so far, is unclear. (C) 2015 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.
- Issue Date
- 2016
- Status
- published
- Publisher
- Elsevier Science Inc
- Journal
- Journal of Thoracic Oncology
- ISSN
- 1556-1380; 1556-0864