Stroke-like pattern in DTI and MRS of childhood mitochondrial leukoencephalopathy
2004 | journal article. A publication with affiliation to the University of Göttingen.
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- Authors
- Brockmann, Knut ; Finsterbusch, Jürgen; Schara, Ulrike; Wilichowski, Ekkehard ; Frahm, Jens ; Hanefeld, Folker
- Abstract
- In a 13-month-old boy with recurrent motor deterioration provoked by fever MRI and proton MRS detected a leukoencephalopathy with reduced cerebral metabolites and elevated lactate. At follow-up 6 and 16 months later these abnormalities improved gradually. Serial diffusion tensor imaging revealed a stroke-like pattern with an initial strong reduction of the apparent diffusion coefficient followed by elevated values 6 months later. The relative diffusion anisotropy remained reduced. Muscle biopsy confirmed a mitochondrial encephalomyopathy.
- Issue Date
- 2004
- Journal
- Neuroradiology
- ISSN
- 0028-3940