Modeling myocardial growth and hypertrophy in engineered heart muscle
2014 | journal article; overview. A publication with affiliation to the University of Göttingen.
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Details
- Authors
- Tiburcy, Malte ; Zimmermann, Wolfram-Hubertus
- Abstract
- The introduction of biomimetic culture paradigms has advanced myocardial tissue engineering fundamentally, enabling today the provision of engineered rodent and human heart muscle with features characteristically found in postnatal myocardium. This is in marked contrasts to "flat" cardiomyocyte cultures with their typically low degree of organotypic maturation. Here, we discuss the collagen hydrogel-based engineered heart muscle (EHM) technology and provide background information on its use in simulations of myocardial growth and disease. (C) 2013 Elsevier Inc. All rights reserved.
- Issue Date
- 2014
- Journal
- Trends in Cardiovascular Medicine
- Project
- SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz
SFB 1002 | C04: Fibroblasten-Kardiomyozyten Interaktion im gesunden und erkrankten Herzen: Mechanismen und therapeutische Interventionen bei Kardiofibroblastopathien - Working Group
- RG Tiburcy (Stem Cell Disease Modeling)
RG Zimmermann (Engineered Human Myocardium) - ISSN
- 1050-1738
