RG Tiburcy (Stem Cell Disease Modeling)

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  • 2024 | Journal Article
    ​ ​Protocol to develop force-generating human skeletal muscle organoids​
    Shahriyari, M.; Rinn, M.; Hofemeier, A. D.; Babych, A.; Zimmermann, W.-H. & Tiburcy, M.​ (2024) 
    STAR Protocols, 5(1) art. 102794​.​ DOI: https://doi.org/10.1016/j.xpro.2023.102794 
    ​Details  DOI  PMID  PMC 
  • 2023 | Journal Article
    ​ ​Therapeutic efficacy of AAV-mediated restoration of PKP2 in arrhythmogenic cardiomyopathy​
    Kyriakopoulou, E.; Versteeg, D.; de Ruiter, H.; Perini, I.; Seibertz, F.; Döring, Y. & Zentilin, L. et al.​ (2023) 
    Nature cardiovascular research, 2(12) pp. 1262​-1276​.​ DOI: https://doi.org/10.1038/s44161-023-00378-9 
    ​Details  DOI 
  • 2023 | Journal Article
    ​ ​Atrial fibrillation-associated electrical remodelling in human induced pluripotent stem cell-derived atrial cardiomyocytes: a novel pathway for antiarrhythmic therapy development​
    Seibertz, F.; Rubio, T.; Springer, R.; Popp, F.; Ritter, M.; Liutkute, A. & Bartelt, L. et al.​ (2023) 
    Cardiovascular Research, art. cvad143​.​ DOI: https://doi.org/10.1093/cvr/cvad143 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | 
    ​ ​Engineered skeletal muscle recapitulates human muscle development, regeneration and dystrophy​
    Shahriyari, M.; Islam, M. R.; Sakib, S. M.; Rinn, M.; Rika, A.; Krüger, D. & Kaurani, L. et al.​ (2022) 
    Journal of Cachexia, Sarcopenia and Muscle, 13(6) art. jcsm.13094​.​ DOI: https://doi.org/10.1002/jcsm.13094 
    ​Details  DOI 
  • 2022 | Journal Article | Research Paper
    ​ ​Using different geometries to modulate the cardiac fibroblast phenotype and the biomechanical properties of engineered connective tissues​
    Santos, G. L.; DeGrave, A. N.; Rehman, A.; Al Disi, S.; Xhaxho, K.; Schröder, H. & Bao, G. et al.​ (2022) 
    Biomaterials Advances, 139 art. 213041​.​ DOI: https://doi.org/10.1016/j.bioadv.2022.213041 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | Overview | 
    ​ ​The Evolution of Complex Muscle Cell In Vitro Models to Study Pathomechanisms and Drug Development of Neuromuscular Disease​
    Zschüntzsch, J.; Meyer, S.; Shahriyari, M.; Kummer, K.; Schmidt, M.; Kummer, S. & Tiburcy, M. ​ (2022) 
    Cells, 11(7) pp. 1233​.​ DOI: https://doi.org/10.3390/cells11071233 
    ​Details  DOI 
  • 2021 | Preprint
    ​ ​Human engineered skeletal muscle of hypaxial origin from pluripotent stem cells with advanced function and regenerative capacity​
    Shahriyari, M.; Islam, M. R.; Sakib, M. S.; Rika, A.; Krüger, D.; Kaurani, L.& Anandakumar, H. et al.​ (2021). DOI: https://doi.org/10.1101/2021.07.12.452030 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper
    ​ ​Truncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due to TTN mutations​
    Fomin, A.; Gärtner, A.; Cyganek, L. ; Tiburcy, M. ; Tuleta, I.; Wellers, L. & Folsche, L. et al.​ (2021) 
    Science Translational Medicine, 13(618).​ DOI: https://doi.org/10.1126/scitranslmed.abd3079 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper
    ​ ​Fibroblast Derived Human Engineered Connective Tissue for Screening Applications​
    Santos, G. L.; Meyer, T. ; Tiburcy, M. ; DeGrave, A.; Zimmermann, W.-H.   & Lutz, S. ​ (2021) 
    Journal of Visualized Experiments,(174).​ DOI: https://doi.org/10.3791/62700 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Generation of Engineered Human Myocardium in a Multi-well Format​
    Tiburcy, M. ; Meyer, T. ; Liaw, N. Y. & Zimmermann, W.-H. ​ (2020) 
    STAR Protocols, 1(1) art. 100032​.​ DOI: https://doi.org/10.1016/j.xpro.2020.100032 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Long‐term human IgG treatment improves heart and muscle function in a mouse model of Duchenne muscular dystrophy​
    Zschüntzsch, J. ; Jouvenal, P. V.; Zhang, Y.; Klinker, F. ; Tiburcy, M. ; Liebetanz, D.   & Malzahn, D.  et al.​ (2020) 
    Journal of Cachexia, Sarcopenia and Muscle, 11(4) pp. 1018​-1031​.​ DOI: https://doi.org/10.1002/jcsm.12569 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Troponin destabilization impairs sarcomere-cytoskeleton interactions in iPSC-derived cardiomyocytes from dilated cardiomyopathy patients​
    Dai, Y.; Amenov, A.; Ignatyeva, N.; Koschinski, A.; Xu, H.; Soong, P. L.   & Tiburcy, M.  et al.​ (2020) 
    Scientific Reports, 10(1) art. 209​.​ DOI: https://doi.org/10.1038/s41598-019-56597-3 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​CRISPLD1: a novel conserved target in the transition to human heart failure​
    Khadjeh, S. ; Hindmarsh, V.; Weber, F.; Cyganek, L. ; Vidal, R. O. ; Torkieh, S. & Streckfuss-Bömeke, K.  et al.​ (2020) 
    Basic Research in Cardiology, 115(3).​ DOI: https://doi.org/10.1007/s00395-020-0784-4 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper
    ​ ​Inhibition of Prolyl-Hydroxylase Domain Enzymes Protects From Reoxygenation Injury in Engineered Human Myocardium​
    Levent, E. ; Noack, C. ; Zelarayán, L. C. ; Katschinski, D. M. ; Zimmermann, W.-H.   & Tiburcy, M. ​ (2020) 
    Circulation, 142(17) pp. 1694​-1696​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.119.044471 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper
    ​ ​Intronic CRISPR Repair in a Preclinical Model of Noonan Syndrome–Associated Cardiomyopathy​
    Hanses, U.; Kleinsorge, M.; Roos, L.; Yigit, G. ; Li, Y. ; Barbarics, B. & El-Battrawy, I. et al.​ (2020) 
    Circulation, 142(11) pp. 1059​-1076​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.119.044794 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper
    ​ ​Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide​
    Montiel, V.; Bella, R.; Michel, L. Y. M.; Esfahani, H.; De Mulder, D.; Robinson, E. L. & Deglasse, J.-P. et al.​ (2020) 
    Science Translational Medicine, 12(564) art. eaay2176​.​ DOI: https://doi.org/10.1126/scitranslmed.aay2176 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper
    ​ ​Engineered heart tissue models from hiPSC-derived cardiomyocytes and cardiac ECM for disease modeling and drug testing applications​
    Goldfracht, I.; Efraim, Y.; Shinnawi, R.; Kovalev, E.; Huber, I.; Gepstein, A. & Arbel, G. et al.​ (2019) 
    Acta Biomaterialia, 92 pp. 145​-159​.​ DOI: https://doi.org/10.1016/j.actbio.2019.05.016 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper
    ​ ​Cardiac macrotissues-on-a-plate models for phenotypic drug screens​
    Meyer, T. ; Tiburcy, M.   & Zimmermann, W.-H. ​ (2019) 
    Advanced Drug Delivery Reviews, 140 pp. 93​-100​.​ DOI: https://doi.org/10.1016/j.addr.2019.03.002 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Agonistic and antagonistic roles of fibroblasts and cardiomyocytes on viscoelastic stiffening of engineered human myocardium​
    Schlick, S. F. ; Spreckelsen, F.; Tiburcy, M. ; Iyer, L. M. ; Meyer, T. ; Zelarayan, L. C.   & Luther, S.  et al.​ (2019) 
    Progress in Biophysics and Molecular Biology, 144 pp. 51​-60​.​ DOI: https://doi.org/10.1016/j.pbiomolbio.2018.11.011 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | 
    ​ ​Regeneration competent satellite cell niches in rat engineered skeletal muscle​
    Tiburcy, M. ; Markov, A.; Kraemer, L. K.; Christalla, P.; Rave-Fränk, M. ; Fischer, H. J.   & Reichardt, H. M.  et al.​ (2019) 
    FASEB BioAdvances, 1(12) pp. 731​-746​.​ DOI: https://doi.org/10.1096/fba.2019-00013 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper | 
    ​ ​Deep phenotyping of human induced pluripotent stem cell–derived atrial and ventricular cardiomyocytes​
    Cyganek, L. ; Tiburcy, M. ; Sekeres, K.; Gerstenberg, K.; Bohnenberger, H. ; Lenz, C.   & Henze, S.  et al.​ (2018) 
    JCI Insight, 3(12) art. e99941​.​ DOI: https://doi.org/10.1172/jci.insight.99941 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing​
    Long, C.; Li, H.; Tiburcy, M. ; Rodriguez-Caycedo, C.; Kyrychenko, V.; Zhou, H. & Zhang, Y. et al.​ (2018) 
    Science Advances, 4(1) art. eaap9004​.​ DOI: https://doi.org/10.1126/sciadv.aap9004 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper
    ​ ​Heat shock protein 47 knockout in fibroblasts causes contractile dysfunction in engineered human myocardium​
    Sur, S.; Noack, C.; Christalla, P.; Tiburcy, M. ; Nagata, K.; Mayr, M. & Zimmermann, W.-H. ​ (2017) 
    European Heart Journal, 38(suppl_1) art. 5044​.​ DOI: https://doi.org/10.1093/eurheartj/ehx493.5044 
    ​Details  DOI 
  • 2017 | Book Chapter
    ​ ​State-of-the-Art in Tissue-Engineered Heart Repair​
    Fujita, B. ; Tiburcy, M. ; Ensminger, S.& Zimmermann, W.-H. ​ (2017)
    In:​Ieda, Masaki; Zimmermann, Wolfram-Hubertus​ (Eds.), Cardiac Regeneration pp. 219​-239. ​Cham, Switzerland: ​Springer. DOI: https://doi.org/10.1007/978-3-319-56106-6_10 
    ​Details  DOI 
  • 2017 | Journal Article | Research Paper
    ​ ​Inducible paracrine release of IGF-1 improves heart muscle thickness and function​
    Soong, P. L. ; Sur, S.; Fujita, B. ; Grishina, E.; Kuzyakova, M.; Tiburcy, M.   & Zimmermann, W. H. ​ (2017) 
    European Heart Journal, 38(suppl_1) art. P2545​.​ DOI: https://doi.org/10.1093/eurheartj/ehx502.P2545 
    ​Details  DOI 
  • 2017 | Journal Article | Research Paper
    ​ ​Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair​
    Tiburcy, M. ; Hudson, J. E.; Balfanz, P.; Schlick, S.; Meyer, T. ; Chang Liao, M.-L. & Levent, E. et al.​ (2017) 
    Circulation, 135(19) pp. 1832​-1847​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.116.024145 
    ​Details  DOI 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Severe DCM phenotype of patient harboring RBM20 mutation S635A can be modeled by patient-specific induced pluripotent stem cell-derived cardiomyocytes​
    Streckfuss-Bömeke, K. ; Tiburcy, M. ; Fomin, A.; Luo, X.; Li, W.; Fischer, C. & Özcelik, C. et al.​ (2017) 
    Journal of Molecular and Cellular Cardiology, 113 pp. 9​-21​.​ DOI: https://doi.org/10.1016/j.yjmcc.2017.09.008 
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  • 2017 | Journal Article | Research Paper
    ​ ​Passive Stretch Induces Structural and Functional Maturation of Engineered Heart Muscle as Predicted by Computational Modeling​
    Abilez, O. J.; Tzatzalos, E.; Yang, H.; Zhao, M.-T.; Jung, G.; Zöllner, A. M. & Tiburcy, M.  et al.​ (2017) 
    Stem Cells, 36(2) pp. 265​-277​.​ DOI: https://doi.org/10.1002/stem.2732 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Catecholamine-Dependent β-Adrenergic Signaling in a Pluripotent Stem Cell Model of Takotsubo Cardiomyopathy​
    Borchert, T. ; Hübscher, D. ; Guessoum, C. I. ; Lam, T. Lam, Tuan-Dinh D.; Ghadri, J. R.; Schellinger, I. N.   & Tiburcy, M.  et al.​ (2017) 
    Journal of the American College of Cardiology, 70(8) pp. 975​-991​.​ DOI: https://doi.org/10.1016/j.jacc.2017.06.061 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Functional correction of dystrophin actin binding domain mutations by genome editing​
    Kyrychenko, V.; Kyrychenko, S.; Tiburcy, M. ; Shelton, J. M.; Long, C.; Schneider, J. W. & Zimmermann, W.-H.  et al.​ (2017) 
    JCI Insight, 2(18) art. e95918​.​ DOI: https://doi.org/10.1172/jci.insight.95918 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article | Research Paper
    ​ ​Magnetic Resonance Imaging of Cardiac Strain Pattern Following Transplantation of Human Tissue Engineered Heart Muscles​
    Qin, X.; Riegler, J.; Tiburcy, M.; Zhao, X.; Chour, T.; Ndoye, B. & Nguyen, M. et al.​ (2016) 
    Circulation: Cardiovascular Imaging, 9(11) art. e004731​.​ DOI: https://doi.org/10.1161/CIRCIMAGING.116.004731 
    ​Details  DOI 
  • 2015 | Journal Article | Research Paper | 
    ​ ​RhoA Ambivalently Controls Prominent Myofibroblast Characteritics by Involving Distinct Signaling Routes​
    Jatho, A. ; Hartmann, S.; Kittana, N.; Muegge, F.; Wuertz, C. M. ; Tiburcy, M.   & Zimmermann, W.-H.  et al.​ (2015) 
    PLoS ONE, 10(10) art. e0137519​.​ DOI: https://doi.org/10.1371/journal.pone.0137519 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper
    ​ ​Physiologic force-frequency response in engineered heart muscle by electromechanical stimulation​
    Godier-Furnemont, A. F. G.; Tiburcy, M. ; Wagner, E. ; Dewenter, M. ; Laemmle, S.; El-Armouche, A.   & Lehnart, S. E.  et al.​ (2015) 
    Biomaterials, 60 pp. 82​-91​.​ DOI: https://doi.org/10.1016/j.biomaterials.2015.03.055 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper | 
    ​ ​Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function​
    Sharma, P.; Abbasi, C.; Lazic, S.; Teng, A. C. T.; Wang, D.; Dubois, N. & Ignatchenko, V. et al.​ (2015) 
    Nature Communications, 6 art. 8391​.​ DOI: https://doi.org/10.1038/ncomms9391 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper
    ​ ​Human Engineered Heart Muscles Engraft and Survive Long Term in a Rodent Myocardial Infarction Model​
    Riegler, J.; Tiburcy, M. ; Ebert, A. ; Tzatzalos, E.; Raaz, U. ; Abilez, O. J. & Shen, Q. et al.​ (2015) 
    Circulation Research, 117(8) pp. 720​-730​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.115.306985 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper
    ​ ​p63RhoGEF regulates auto- and paracrine signaling in cardiac fibroblasts​
    Ongherth, A.; Pasch, S.; Wuertz, C. M. ; Nowak, K.; Kittana, N.; Weis, C. A. & Jatho, A.  et al.​ (2015) 
    Journal of Molecular and Cellular Cardiology, 88 pp. 39​-54​.​ DOI: https://doi.org/10.1016/j.yjmcc.2015.09.009 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper | 
    ​ ​Lights on for HIF-1 alpha: Genetically Enhanced Mouse Cardiomyocytes for Heart Tissue Imaging​
    Hesse, A. R.; Levent, E. ; Zieseniss, A. ; Tiburcy, M. ; Zimmermann, W.-H.   & Katschinski, D. M. ​ (2014) 
    Cellular Physiology and Biochemistry, 34(2) pp. 455​-462​.​ DOI: https://doi.org/10.1159/000363014 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Overview
    ​ ​Modeling myocardial growth and hypertrophy in engineered heart muscle​
    Tiburcy, M.   & Zimmermann, W.-H. ​ (2014) 
    Trends in Cardiovascular Medicine, 24(1) pp. 7​-13​.​ DOI: https://doi.org/10.1016/j.tcm.2013.05.003 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Book Chapter
    ​ ​Collagen-Based Engineered Heart Muscle​
    Tiburcy, M. ; Meyer, T. ; Soong, P. L.  & Zimmermann, W.-H. ​ (2014)
    In: Cardiac Tissue Engineering pp. 167​-176. ​New York: ​Humana Press. DOI: https://doi.org/10.1007/978-1-4939-1047-2_15 
    ​Details  DOI  PMID  PMC 
  • 2014 | Journal Article | Research Paper | 
    ​ ​miR-133a Enhances the Protective Capacity of Cardiac Progenitors Cells after Myocardial Infarction​
    Izarra, A.; Moscoso, I.; Levent, E. ; Canon, S.; Cerrada, I.; Diez-Juan, A. & Blanca, V. et al.​ (2014) 
    Stem Cell Reports, 3(6) pp. 1029​-1042​.​ DOI: https://doi.org/10.1016/j.stemcr.2014.10.010 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper | 
    ​ ​Enhanced Ca2+ influx through cardiac L-type Ca2+ channels maintains the systolic Ca2+ transient in early cardiac atrophy induced by mechanical unloading​
    Schwoerer, A. P.; Neef, S.; Broichhausen, I.; Jacubeit, J.; Tiburcy, M. ; Wagner, M. & Biermann, D. et al.​ (2013) 
    Pflügers Archiv - European Journal of Physiology, 465(12) pp. 1763​-1773​.​ DOI: https://doi.org/10.1007/s00424-013-1316-y 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​Comparative study of human-induced pluripotent stem cells derived from bone marrow cells, hair keratinocytes, and skin fibroblasts​
    Streckfuss-Boemeke, K. ; Wolf, F.; Azizian, A. ; Stauske, M.; Tiburcy, M. ; Wagner, S.   & Huebscher, D.  et al.​ (2013) 
    European heart journal, 34(33) pp. 2618​-2629​.​ DOI: https://doi.org/10.1093/eurheartj/ehs203 
    ​Details  DOI  PMID  PMC  WoS 

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