Lack of an Association between the Functional Polymorphism TREM-1 rs2234237 and the Clinical Course of Sepsis among Critically Ill Caucasian Patients-A Monocentric Prospective Genetic Association Study
2019 | journal article. A publication with affiliation to the University of Göttingen.
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Lack of an Association between the Functional Polymorphism TREM-1 rs2234237 and the Clinical Course of Sepsis among Critically Ill Caucasian Patients-A Monocentric Prospective Genetic Association Study
Runzheimer, J.; Mewes, C.; Büttner, B. ; Hinz, J. M. ; Popov, A.-F.; Ghadimi, M. B. & Kristof, K. et al. (2019)
Journal of Clinical Medicine, 8(3) art. 301. DOI: https://doi.org/10.3390/jcm8030301
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Details
- Authors
- Runzheimer, Julius; Mewes, Caspar; Büttner, Benedikt ; Hinz, José Maria ; Popov, Aron-Frederik; Ghadimi, Michael B. ; Kristof, Katalin; Beißbarth, Tim ; Schamroth, Joel; Tzvetkov, Mladen Vassilev ; Schmack, Bastian; Quintel, Michael I. ; Bergmann, Ingo ; Mansur, Ashham
- Abstract
- Sepsis is a life-threatening condition and a significant challenge for those working in intensive care, where it remains one of the leading causes of mortality. According to the sepsis-3 definition, sepsis is characterized by dysregulation of the host response to infection. The TREM-1 gene codes for the triggering receptor expressed on myeloid cells 1, which is part of the pro-inflammatory response of the immune system. This study aimed to determine whether the functional TREM-1 rs2234237 single nucleotide polymorphism was associated with mortality in a cohort of 649 Caucasian patients with sepsis. The 90-day mortality rate was the primary outcome, and disease severity and microbiological findings were analyzed as secondary endpoints. TREM-1 rs2234237 TT homozygous patients were compared to A-allele carriers for this purpose. Kaplan⁻Meier survival analysis revealed no association between the clinically relevant TREM-1 rs2234237 single nucleotide polymorphism and the 90-day or 28-day survival rate in this group of septic patients. In addition, the performed analyses of disease severity and the microbiological findings did not show significant differences between the TREM-1 rs2234237 genotypes. The TREM-1 rs2234237 genotype was not significantly associated with sepsis mortality and sepsis disease severity. Therefore, it was not a valuable prognostic marker for the survival of septic patients in the studied cohort.
- Issue Date
- 2019
- Publisher
- MDPI
- Journal
- Journal of Clinical Medicine
- ISSN
- 2077-0383
- eISSN
- 2077-0383
- Language
- English
- Sponsor
- Volkswagen Foundation