Hippocampal cannabinoid-1 receptor upregulation upon endothelin-B receptor deficiency: A neuroprotective substitution effect?
2005 | journal article
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Hippocampal cannabinoid-1 receptor upregulation upon endothelin-B receptor deficiency: A neuroprotective substitution effect?
Unzicker, C. ; Erberich, H. ; Moldrich, G. ; Woldt, H. ; Bulla, J.; Mechoulam, R. & Ehrenreich, H. et al. (2005)
Neurochemical Research, 30(10) pp. 1305-1309. DOI: https://doi.org/10.1007/s11064-005-8802-3
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- Authors
- Unzicker, Christian ; Erberich, Heike ; Moldrich, Gabriella ; Woldt, Helge ; Bulla, Jan; Mechoulam, Raphael; Ehrenreich, Hannelore ; Sirén, Anna-Leena
- Abstract
- Endothelin (ETB)-receptors mediate anti-apoptotic actions. Lack of functional ETB-receptors leads to increased neuronal apoptosis in the hippocampus. The increased apoptosis must be compensated by other mechanisms, however, as ETB-deficient rats display normal overall brain morphology. To illuminate on brain plasticity in ETB-receptor deficiency, we studied the expression and function of another neuroprotective system, the cannabinoid CB1-receptors, in ETB-deficient hippocampus. We show that CB1 expression in hippocampus increases postnatally in all rats but that the increase in CB1-receptor expression is significantly higher in ETB-deficient compared to wildtype littermates. Neuronal apoptosis decreases during brain maturation but remains on a significantly higher level in the ETB-deficient compared to wildtype dentate. When investigating survival of hippocampal neurons in culture, we found significant protection against hypoxia-induced cell death with CB1-analogs (noladin, (9-tetrahydrocannabinol) only in ETB-deficient neurons. We suggest that CB1-receptor upregulation in the ETB-mutant hippocampus reflects an attempt to compensate for the lack of ETB-receptors.
- Issue Date
- 2005
- Journal
- Neurochemical Research
- Language
- English