Exploring the thermodynamic derivatives of the structure factor of dense protein solutions

Abstract

Using small-angle X-ray scattering data of concentrated solutions of the protein lysozyme taken at different pressures and temperatures, the isothermal pressure derivative and the isobaric temperature derivative of the structure factor S(q) were determined. The pressure derivative of S(q) allows us to test various models for the triplet correlation function g(3). Significant differences were found in comparison to simple liquids reflecting the more complex interaction potential in dense protein solutions.