Nonlinear pressure dependence of the interaction potential of dense protein solutions
2011-04-29 | journal article; research paper
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Nonlinear pressure dependence of the interaction potential of dense protein solutions
Schroer, M. A.; Markgraf, J.; Wieland, D. C. F.; Sahle, C. J.; Möller, J.; Paulus, M. & Tolan, M. et al. (2011)
Physical Review Letters, 106(17) art. 178102. DOI: https://doi.org/10.1103/PhysRevLett.106.178102
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Details
- Authors
- Schroer, Martin A.; Markgraf, Jonas; Wieland, D. C. Florian; Sahle, Christoph J.; Möller, Johannes; Paulus, Michael; Tolan, Metin ; Winter, Roland
- Abstract
- The influence of pressure on the structure and protein-protein interaction potential of dense protein solutions was studied and analyzed using small-angle x-ray scattering in combination with a liquid state theoretical approach. The structural as well as the interaction parameters of dense lysozyme solutions are affected by pressure in a nonlinear way. The structural properties of water lead to a modification of the protein-protein interactions below 4 kbar, which might have significant consequences for the stability of proteins in extreme natural environments.
- Issue Date
- 29-April-2011
- Journal
- Physical Review Letters
- ISSN
- 0031-9007
- eISSN
- 1079-7114
- Language
- English
