Corticotropin-releasing factor binding protein--a ligand trap?
2005-10 | journal article; research paper
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Details
- Authors
- Jahn, Olaf ; Radulovic, Jelena; Stiedl, Oliver; Tezval, Hossein; Eckart, Klaus; Spiess, Joachim
- Abstract
- The actions of the neuropeptide corticotropin-releasing factor (CRF) are modulated by a CRF binding protein (CRFBP). In view of the memory-enhancing effects of CRF, the release of endogenous CRF from CRFBP by CRFBP inhibitors has been suggested as a therapeutical strategy for the treatment of cognitive deficits. This mini-review will summarize recent advances in the field with a focus on the pharmaceutical potential of CRFBP inhibitors.
- Issue Date
- October-2005
- Journal
- Mini-Reviews in ... Medicinal Chemistry
- ISSN
- 1389-5575
- Language
- English