SFB 1002 | A08: Translationale und posttranslationale Kontrolle trunkierter Titinproteine in Kardiomyozyten von Patienten mit dilatativer Kardiomyopathie RSS Feed


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  • 2022 | Journal Article | Research Paper | 
    ​ ​Targeted therapies in genetic dilated and hypertrophic cardiomyopathies: from molecular mechanisms to therapeutic targets. A position paper from the Heart Failure Association (HFA) and the Working Group on Myocardial Function of the European Society of Cardiology (ESC)​
    de Boer, R. A.; Heymans, S.; Backs, J.; Carrier, L.; Coats, A. J. S.; Dimmeler, S. & Eschenhagen, T. et al.​ (2022) 
    European Journal of Heart Failure, 24(3) pp. 406​-420​.​ DOI: https://doi.org/10.1002/ejhf.2414 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | 
    ​ ​Unraveling the mysteries of the titin-N2A signalosome​
    Hessel, A. L. & Linke, W. A. ​ (2021) 
    The Journal of General Physiology, 153(8).​ DOI: https://doi.org/10.1085/jgp.202112967 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin​
    Swist, S.; Unger, A.; Li, Y.; Vöge, A.; von Frieling-Salewsky, M.; Skärlén, Å. & Cacciani, N. et al.​ (2020) 
    Nature Communications, 11(1) pp. 4479​.​ DOI: https://doi.org/10.1038/s41467-020-18131-2 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Overview | 
    ​ ​Posttranslational modifications of titin from cardiac muscle: how, where, and what for?​
    Koser, F.; Loescher, C. & Linke, W. A. ​ (2019) 
    The FEBS Journal, 286(12) pp. 2240​-2260​.​ DOI: https://doi.org/10.1111/febs.14854 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper | 
    ​ ​Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes​
    Krysiak, J.; Unger, A.; Beckendorf, L.; Hamdani, N.; Frieling-Salewsky, M. von; Redfield, M. M. & Remedios, C. G. dos et al.​ (2018) 
    Nature Communications, 9(1) art. 262​.​ DOI: https://doi.org/10.1038/s41467-017-02483-3 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Dietary spermidine for lowering high blood pressure​
    Eisenberg, T.; Abdellatif, M.; Zimmermann, A.; Schroeder, S.; Pendl, T.; Harger, A. & Stekovic, S. et al.​ (2017) 
    Autophagy, 13(4) pp. 767​-769​.​ DOI: https://doi.org/10.1080/15548627.2017.1280225 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Overview | 
    ​ ​Tampering with springs: phosphorylation of titin affecting the mechanical function of cardiomyocytes​
    Hamdani, N.; Herwig, M. & Linke, W. A. ​ (2017) 
    Biophysical Reviews, 9(3) pp. 225​-237​.​ DOI: https://doi.org/10.1007/s12551-017-0263-9 
    ​Details  DOI 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Severe DCM phenotype of patient harboring RBM20 mutation S635A can be modeled by patient-specific induced pluripotent stem cell-derived cardiomyocytes​
    Streckfuss-Bömeke, K. ; Tiburcy, M. ; Fomin, A.; Luo, X.; Li, W.; Fischer, C. & Özcelik, C. et al.​ (2017) 
    Journal of Molecular and Cellular Cardiology, 113 pp. 9​-21​.​ DOI: https://doi.org/10.1016/j.yjmcc.2017.09.008 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article | Research Paper | 
    ​ ​Molecular and structural transition mechanisms in long-term volume overload​
    Mohamed, B. A. ; Schnelle, M. ; Khadjeh, S. ; Lbik, D.; Herwig, M.; Linke, W. A.   & Hasenfuß, G.  et al.​ (2016) 
    European Journal of Heart Failure, 18(4) pp. 362​-371​.​ DOI: https://doi.org/10.1002/ejhf.465 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Overview | 
    ​ ​Emerging importance of oxidative stress in regulating striated muscle elasticity​
    Beckendorf, L. & Linke, W. A. ​ (2015) 
    Journal of Muscle Research and Cell Motility, 36(1) pp. 25​-36​.​ DOI: https://doi.org/10.1007/s10974-014-9392-y 
    ​Details  DOI 

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