Prof. Dr. Jürgen Brockmöller

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  • 2022 | Journal Article
    ​ ​Gebauer, Lukas, et al. "Substrates and Inhibitors of the Organic Cation Transporter 3 and Comparison with OCT1 and OCT2​." ​Journal of Medicinal Chemistry, vol. 65, no. 18, ​2022, pp. 12403​-12416​, ​doi: 10.1021/acs.jmedchem.2c01075. 
    ​Details  DOI 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Jensen, Ole, et al. "Relationships between Inhibition, Transport and Enhanced Transport via the Organic Cation Transporter 1​." ​International Journal of Molecular Sciences, vol. 23, no. 4, ​2022, p. 2007​, ​doi: 10.3390/ijms23042007. 
    ​Details  DOI 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Doetsch, David A., et al. "Substrates of the Human Brain Proton-Organic Cation Antiporter and Comparison with Organic Cation Transporter 1 Activities​." ​International Journal of Molecular Sciences, vol. 23, no. 15, ​2022, p. 8430​, ​doi: 10.3390/ijms23158430. 
    ​Details  DOI 
  • 2022 | Journal Article
    ​ ​Sachkova, Alexandra, et al. "The mystery of the human proton-organic cation antiporter: One transport protein or many?​." ​Pharmacology & Therapeutics, vol. 239, ​2022, p. 108283​, ​doi: 10.1016/j.pharmthera.2022.108283. 
    ​Details  DOI 
  • 2021 | Journal Article
    ​ ​Dücker, Christof, and Jürgen Brockmöller. "How precise is quantitative prediction of pharmacokinetic effects due to drug-drug interactions and genotype from in vitro data? A comprehensive analysis on the example CYP2D6 and CYP2C19 substrates​." ​Pharmacology & Therapeutics, vol. 217, ​2021, p. 107629​, ​doi: 10.1016/j.pharmthera.2020.107629. 
    ​Details  DOI 
  • 2021 | Journal Article
    ​ ​Jensen, Ole, Jürgen Brockmöller, and Christof Dücker. "Identification of Novel High-Affinity Substrates of OCT1 Using Machine Learning-Guided Virtual Screening and Experimental Validation​." ​Journal of Medicinal Chemistry, vol. 64, no. 5, ​2021, pp. 2762​-2776​, ​doi: 10.1021/acs.jmedchem.0c02047. 
    ​Details  DOI 
  • 2021 | Journal Article
    ​ ​Rossi, Simone, et al. "Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines​." ​Clinical Neurophysiology, vol. 132, no. 1, ​2021, pp. 269​-306​, ​doi: 10.1016/j.clinph.2020.10.003. 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Jensen, Ole, et al. "Cellular Uptake of Psychostimulants – Are High- and Low-Affinity Organic Cation Transporters Drug Traffickers?​." ​Frontiers in Pharmacology, vol. 11, ​2021, , ​doi: 10.3389/fphar.2020.609811. 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Jensen, Ole, et al. "A double-Flp-in method for stable overexpression of two genes​." ​Scientific Reports, vol. 10, no. 1, ​2020, , ​doi: 10.1038/s41598-020-71051-5. 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Matthaei, Johannes, et al. "Inherited and Acquired Determinants of Hepatic CYP3A Activity in Humans​." ​Frontiers in Genetics, vol. 11, ​2020, , ​doi: 10.3389/fgene.2020.00944. 
    ​Details  DOI 
  • 2020 | Journal Article | Research Paper
    ​ ​Jensen, Ole, et al. "Stereoselective cell uptake of adrenergic agonists and antagonists by organic cation transporters​." ​Biochemical Pharmacology, vol. 171, ​2020, p. 113731​, ​doi: 10.1016/j.bcp.2019.113731. 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article
    ​ ​Meyer, Marleen J., et al. "Opioids as Substrates and Inhibitors of the Genetically Highly Variable Organic Cation Transporter OCT1​." ​Journal of Medicinal Chemistry, vol. 62, no. 21, ​2019, pp. 9890​-9905​, ​doi: 10.1021/acs.jmedchem.9b01301. 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Amare, Azmeraw T., et al. "The association of obesity and coronary artery disease genes with response to SSRIs treatment in major depression​." ​Journal of Neural Transmission, vol. 126, no. 1, ​2019, pp. 35​-45​, ​doi: 10.1007/s00702-018-01966-x. 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​CHEN, Jia-Yin, et al. "An in vitro study on interaction of anisodine and monocrotaline with organic cation transporters of the SLC22 and SLC47 families​." ​Chinese Journal of Natural Medicines, vol. 17, no. 7, ​2019, pp. 490​-497​, ​doi: 10.1016/S1875-5364(19)30070-6. 
    ​Details  DOI 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Heinemann, Stephanie, et al. "Why Z-drugs are used even if doctors and nurses feel unable to judge their benefits and risks—a hospital survey​." ​European Journal of Clinical Pharmacology, vol. 76, no. 2, ​2019, pp. 285​-290​, ​doi: 10.1007/s00228-019-02783-1. 
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​Jensen, Ole, et al. "Variability and heritability of thiamine pharmacokinetics with focus on OCT1 effects on membrane transport and pharmacokinetics in humans​." ​Clinical Pharmacology and Therapeutics, vol. 107, no. 3, ​2019, pp. 628​-638​, ​doi: 10.1002/cpt.1666. 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Rafehi, Muhammad, et al. "Highly Variable Pharmacokinetics of Tyramine in Humans and Polymorphisms in OCT1, CYP2D6, and MAO-A​." ​Frontiers in Pharmacology, vol. 10, ​2019, p. 1297​, ​doi: 10.3389/fphar.2019.01297. 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article
    ​ ​Matthaei, Johannes, et al. "OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil​." ​Clinical Pharmacology and Therapeutics, vol. 105, no. 1, ​2019, pp. 190​-200​, ​doi: 10.1002/cpt.1128. 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article
    ​ ​Amare, Azmeraw T., et al. "Association of the Polygenic Scores for Personality Traits and Response to Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder​." ​Frontiers in Psychiatry, vol. 9, ​2018, , ​doi: 10.3389/fpsyt.2018.00065. 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Dücker, Christof M., and Jürgen Brockmöller. "Genomic Variation and Pharmacokinetics in Old Age: A Quantitative Review of Age- vs. Genotype-Related Differences​." ​Clinical Pharmacology & Therapeutics, vol. 105, no. 3, ​2018, pp. 625​-640​, ​doi: 10.1002/cpt.1057. 
    ​Details  DOI 
  • 2018 | Journal Article | 
    ​ ​Bokelmann, Kristin, Jürgen Brockmöller, and Mladen Tzvetkov. "Impact of Promoter Polymorphisms on the Transcriptional Regulation of the Organic Cation Transporter OCT1 (SLC22A1)​." ​Journal of Personalized Medicine, vol. 8, no. 4, ​2018, p. 42​, ​doi: 10.3390/jpm8040042. 
    ​Details  DOI 
  • 2018 | Journal Article | 
    ​ ​Scholl, Catharina, et al. "Population nutrikinetics of green tea extract​." ​PLoS One, vol. 13, no. 2, ​2018, p. e0193074​, ​doi: 10.1371/journal.pone.0193074. 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Just, Katja Susanne, et al. "Falls: the adverse drug reaction of the elderly and the impact of pharmacogenetics​." ​Pharmacogenomics, vol. 18, no. 13, ​2017, pp. 1281​-1297​, ​doi: 10.2217/pgs-2017-0018. 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Antal, A., et al. "Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines​." ​Clinical Neurophysiology, vol. 128, no. 9, ​2017, pp. 1774​-1809​, ​doi: 10.1016/j.clinph.2017.06.001. 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Budde, M., et al. "Pharmacogenomic aspects of bipolar disorder: An update​." ​European Neuropsychopharmacology, vol. 27, no. 6, ​2017, pp. 599​-609​, ​doi: 10.1016/j.euroneuro.2017.02.001. 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Tzvetkov, Mladen V., et al. "Increased Systemic Exposure and Stronger Cardiovascular and Metabolic Adverse Reactions to Fenoterol in Individuals with Heritable OCT1 Deficiency​." ​Clinical Pharmacology & Therapeutics, vol. 103, no. 5, ​2017, pp. 868​-878​, ​doi: 10.1002/cpt.812. 
    ​Details  DOI 
  • 2017 | Journal Article | 
    ​ ​Meyer, Marleen Julia, et al. "Effects of genetic polymorphisms on the OCT1 and OCT2-mediated uptake of ranitidine​." ​PLOS ONE, vol. 12, no. 12, ​2017, , ​doi: 10.1371/journal.pone.0189521. 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article
    ​ ​Schütz, Ekkehard, et al. "Graft-derived cell-free DNA, a noninvasive early rejection and graft damage marker in liver transplantation: A prospective, observational, multicenter cohort study​." ​PLoS Medicine, vol. 14, no. 4, ​2017, , ​doi: 10.1371/journal.pmed.1002286. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article
    ​ ​Stamer, Ulrike M., et al. "Loss-of-function polymorphisms in the organic cation transporter OCT1 are associated with reduced postoperative tramadol consumption​." ​Pain, vol. 157, no. 11, ​2016, pp. 2467​-2475​, ​doi: 10.1097/j.pain.0000000000000662. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article
    ​ ​Matthaei, Johannes, et al. "Heritability of Metoprolol and Torsemide Pharmacokinetics​." ​Clinical Pharmacology & Therapeutics, vol. 98, no. 6, ​2015, pp. 611​-621​, ​doi: 10.1002/cpt.258. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article
    ​ ​Boretius, Susann, et al. "Halogenated volatile anesthetics alter brain metabolism as revealed by proton magnetic resonance spectroscopy of mice in vivo​." ​NeuroImage, vol. 69, ​2012, pp. 244​-255​, ​doi: 10.1016/j.neuroimage.2012.12.020. 
    ​Details  DOI  PMID  PMC 
  • 2012 | Journal Article | Research Paper | 
    ​ ​Seegers, Joachim, et al. "Rationale, objectives, and design of the EUTrigTreat clinical study: a prospective observational study for arrhythmia risk stratification and assessment of interrelationships among repolarization markers and genotype​." ​EP Europace, vol. 14, no. 3, ​2012, pp. 416​-422​, ​doi: 10.1093/europace/eur352. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article
    ​ ​Schirmer, Markus Anton, et al. "Acute Toxicity of Radiochemotherapy in Rectal Cancer Patients: A Risk Particularly for Carriers of the TGFB1 Pro25 variant​." ​International Journal of Radiation Oncology*Biology*Physics, vol. 83, no. 1, ​2012, pp. 149​-157​, ​doi: 10.1016/j.ijrobp.2011.05.063. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Conference Abstract
    ​ ​Christiansen, H., et al. "TGFB1 Pro25 allele as a risk marker for higher-grade acute Organ toxicity (CTC >= Grad2) during neoadjuvant Chemoradiotherapy in patients with locally advanced Rectal cancer (UICC Stage II/III)​." ​Strahlentherapie und Onkologie, vol. 187, ​2011, . ​
    ​Details  WoS 
  • 2011 | Journal Article | 
    ​ ​Schirmer, Markus Anton, et al. "A PUTATIVELY FUNCTIONAL HAPLOTYPE IN THE GENE ENCODING TRANSFORMING GROWTH FACTOR BETA-1 AS A POTENTIAL BIOMARKER FOR RADIOSENSITIVITY​." ​International Journal of Radiation Oncology*Biology*Physics, vol. 79, no. 3, ​2011, pp. 866​-874​, ​doi: 10.1016/j.ijrobp.2010.08.040. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2008 | Journal Article
    ​ ​Kirchheiner, Julia, et al. "Genetic variants in FKBP5 affecting response to antidepressant drug treatment​." ​Pharmacogenomics, vol. 9, no. 7, ​2008, pp. 841​-846​, ​doi: 10.2217/14622416.9.7.841. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2008 | Journal Article
    ​ ​Kirchheiner, Julia, et al. "Effects of the CYP2D6 gene duplication on the pharmacokinetics and pharmacodynamics of tramadol​." ​Journal of Clinical Psychopharmacology, vol. 28, no. 1, ​2008, pp. 78​-83​, ​doi: 10.1097/JCP.0b013e318160f827. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2007 | Journal Article
    ​ ​Mössner, Rotraut, et al. "Variations of the melanocortin-1 receptor and the glutathione-S transferase T1 and M1 genes in cutaneous malignant melanoma​." ​Archives of Dermatological Research, vol. 298, no. 8, ​2007, pp. 371​-379​, ​doi: 10.1007/s00403-006-0708-7. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2006 | Journal Article
    ​ ​Vormfelde, Stefan Viktor, et al. "Anxiety- and novelty seeking-related personality traits and serotonin transporter gene polymorphisms​." ​Journal of Psychiatric Research, vol. 40, no. 6, ​2006, pp. 568​-576​, ​doi: 10.1016/j.jpsychires.2005.10.002. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2005 | Journal Article | Research Paper
    ​ ​Wojnowski, Leszek, et al. "NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity​." ​Circulation, vol. 112, no. 24, ​2005, pp. 3754​-3762​, ​doi: 10.1161/CIRCULATIONAHA.105.576850. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2005 | Journal Article | Research Paper
    ​ ​Kulle, Bettina, et al. "Application of genomewide SNP arrays for detection of simulated susceptibility loci​." ​Human Mutation, vol. 25, no. 6, ​2005, pp. 557​-565​, ​doi: 10.1002/humu.20174. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2004 | Journal Article
    ​ ​Smits, K. M., et al. "Association of metabolic gene polymorphisms with tobacco consumption in healthy controls​." ​International Journal of Cancer, vol. 110, no. 2, ​2004, pp. 266​-270​, ​doi: 10.1002/ijc.20114. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2001 | Review
    ​ ​Kirchheiner, J., et al. "CYP2D6 and CYP2C19 genotype-based dose recommendations for antidepressants: a first step towards subpopulation-specific dosages​." ​Acta Psychiatrica Scandinavica, vol. 104, no. 3, ​2001, pp. 173​-192​, ​doi: 10.1034/j.1600-0447.2001.00299.x. 
    ​Details  DOI  PMID  PMC  WoS 

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