Prof. Dr. rer. nat. Oliver Wirths

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  • 2023 | Journal Article | 
    ​ ​Lack of STAT1 co-operative DNA binding protects against adverse cardiac remodelling in acute myocardial infarction​
    Doudin, A.; Riebeling, T.; Staab, J.; Menon, P. R.; Lühder, F.; Wirths, O.   & Vinkemeier, U. et al.​ (2023) 
    Frontiers in Cardiovascular Medicine, 10.​ DOI: https://doi.org/10.3389/fcvm.2023.975012 
    ​Details  DOI 
  • 2022 | Journal Article | 
    ​ ​Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer’s disease​
    Marengo, L.; Armbrust, F.; Schoenherr, C.; Storck, S. E.; Schmitt, U.; Zampar, S. & Wirths, O.  et al.​ (2022) 
    Cellular and Molecular Life Sciences, 79(3) art. 168​.​ DOI: https://doi.org/10.1007/s00018-022-04205-5 
    ​Details  DOI 
  • 2022 | Journal Article | 
    ​ ​Detection and quantification of Aβ−3–40 (APP669‐711) in cerebrospinal fluid​
    Klafki, H.; Wirths, O. ; Mollenhauer, B.; Liepold, T.; Rieper, P.; Esselmann, H. & Vogelgsang, J. et al.​ (2022) 
    Journal of Neurochemistry, 160(5) pp. 578​-589​.​ DOI: https://doi.org/10.1111/jnc.15571 
    ​Details  DOI 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Evaluation of the putative lymphoma-associated point mutation D427H in the STAT3 transcription factor​
    Behrendsen, L. S.; Menon, P. R.; Khan, M. J.; Gregus, A.; Wirths, O. ; Meyer, T.   & Staab, J. ​ (2022) 
    BMC Molecular and Cell Biology, 23(1) art. 23​.​ DOI: https://doi.org/10.1186/s12860-022-00422-9 
    ​Details  DOI 
  • 2021 | Journal Article
    ​ ​The anti-parallel dimer binding interface in STAT3 transcription factor is required for the inactivation of cytokine-mediated signal transduction​
    Menon, P. R.; Doudin, A.; Gregus, A.; Wirths, O. ; Staab, J. & Meyer, T.​ (2021) 
    Biochimica et Biophysica Acta. Molecular Cell Research, art. S0167488921001725​.​ DOI: https://doi.org/10.1016/j.bbamcr.2021.119118 
    ​Details  DOI 
  • 2021 | Journal Article
    ​ ​Physical activity and cognitive stimulation ameliorate learning and motor deficits in a transgenic mouse model of Alzheimer’s disease​
    Stazi, M. & Wirths, O. ​ (2021) 
    Behavioural Brain Research, 397 pp. 112951​.​ DOI: https://doi.org/10.1016/j.bbr.2020.112951 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Characterization of a Mouse Model of Alzheimer’s Disease Expressing Aβ4-42 and Human Mutant Tau​
    Zampar, S. & Wirths, O. ​ (2021) 
    International Journal of Molecular Sciences, 22(10) pp. 5191​.​ DOI: https://doi.org/10.3390/ijms22105191 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper | 
    ​ ​A microRNA signature that correlates with cognition and is a target against cognitive decline​
    Islam, M. R.; Kaurani, L.; Berulava, T.; Heilbronner, U.; Budde, M.; Centeno, T. P. & Elerdashvili, V. et al.​ (2021) 
    EMBO Molecular Medicine, 13(11).​ DOI: https://doi.org/10.15252/emmm.202013659 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article
    ​ ​N‐terminal heterogeneity of parenchymal and vascular amyloid‐β deposits in Alzheimer’s disease​
    Zampar, S.; Klafki, H. W. ; Sritharen, K.; Bayer, T. A. ; Wiltfang, J. ; Rostagno, A. & Ghiso, J. et al.​ (2020) 
    Neuropathology and Applied Neurobiology, 46(7) pp. 673​-685​.​ DOI: https://doi.org/10.1111/nan.12637 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Chronic Memantine Treatment Ameliorates Behavioral Deficits, Neuron Loss, and Impaired Neurogenesis in a Model of Alzheimer’s Disease​
    Stazi, M. & Wirths, O. ​ (2020) 
    Molecular Neurobiology, 58(1) pp. 204​-216​.​ DOI: https://doi.org/10.1007/s12035-020-02120-z 
    ​Details  DOI 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Development and Technical Validation of an Immunoassay for the Detection of APP669–711 (Aβ−3–40) in Biological Samples​
    Klafki, H. W. ; Rieper, P.; Matzen, A.; Zampar, S.; Wirths, O. ; Vogelgsang, J. & Osterloh, D. et al.​ (2020) 
    International Journal of Molecular Sciences, 21(18) pp. 6564​.​ DOI: https://doi.org/10.3390/ijms21186564 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Loss of Hippocampal Calretinin and Parvalbumin Interneurons in the 5XFAD Mouse Model of Alzheimer’s Disease​
    Giesers, N. K. & Wirths, O. ​ (2020) 
    ASN Neuro, 12 pp. 175909142092535​.​ DOI: https://doi.org/10.1177/1759091420925356 
    ​Details  DOI 
  • 2020 | Book Chapter | 
    ​ ​Immunotherapy Targeting Amyloid-β Peptides in Alzheimer’s Disease​
    Zampar, S.& Wirths, O. ​ (2020)
    In:​Huang, Xudong​ (Ed.), Alzheimer’s Disease: Drug Discovery pp. 23​-49. ​Exon Publications. DOI: https://doi.org/10.36255/exonpublications.alzheimersdisease.2020.ch2 
    ​Details  DOI 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Neuron Loss in Alzheimer’s Disease: Translation in Transgenic Mouse Models​
    Wirths, O.   & Zampar, S.​ (2020) 
    International Journal of Molecular Sciences, 21(21) pp. 8144​.​ DOI: https://doi.org/10.3390/ijms21218144 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​N-Terminal Truncated Aβ4-42 Is a Substrate for Neprilysin Degradation in vitro and in vivo​
    Hornung, K.; Zampar, S.; Engel, N.; Klafki, H. ; Liepold, T. ; Bayer, T. A.   & Wiltfang, J.  et al.​ (2019) 
    Journal of Alzheimer's Disease, 67(3) pp. 849​-858​.​ DOI: https://doi.org/10.3233/JAD-181134 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Emerging roles of N- and C-terminally truncated Aβ species in Alzheimer’s disease​
    Wirths, O.   & Zampar, S.​ (2019) 
    Expert Opinion on Therapeutic Targets, 23(12) pp. 991​-1004​.​ DOI: https://doi.org/10.1080/14728222.2019.1702972 
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​Physical Activity Ameliorates Impaired Hippocampal Neurogenesis in the Tg4-42 Mouse Model of Alzheimer’s Disease​
    Gerberding, A.-L.; Zampar, S.; Stazi, M.; Liebetanz, D.   & Wirths, O. ​ (2019) 
    ASN Neuro, 11 pp. 175909141989269​.​ DOI: https://doi.org/10.1177/1759091419892692 
    ​Details  DOI 
  • 2019 | Book Chapter | 
    ​ ​N-Terminally Truncated Aβ Peptide Variants in Alzheimer’s Disease​
    Wirths, O. ; Zampar, S.& Weggen, S.​ (2019)
    In: Alzheimer’s Disease pp. 107​-122.  DOI: https://doi.org/10.15586/alzheimersdisease.2019.ch7 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​The metalloprotease ADAMTS4 generates N-truncated Aβ4–x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer’s disease​
    Walter, S.; Jumpertz, T.; Hüttenrauch, M. ; Ogorek, I.; Gerber, H.; Storck, S. E. & Zampar, S. et al.​ (2018) 
    Acta Neuropathologica, 137(2) pp. 239​-257​.​ DOI: https://doi.org/10.1007/s00401-018-1929-5 
    ​Details  DOI 
  • 2018 | Journal Article | 
    ​ ​Glycoprotein NMB: a novel Alzheimer’s disease associated marker expressed in a subset of activated microglia​
    Hüttenrauch, M.; Ogorek, I.; Klafki, H.; Otto, M.; Stadelmann, C. ; Weggen, S. & Wiltfang, J. et al.​ (2018) 
    Acta Neuropathologica Communications, 6(1) art. 108​.​ DOI: https://doi.org/10.1186/s40478-018-0612-3 
    ​Details  DOI 
  • 2018 | Journal Article | 
    ​ ​The presubiculum is preserved from neurodegenerative changes in Alzheimer’s disease​
    Murray, C. E; Gami-Patel, P.; Gkanatsiou, E.; Brinkmalm, G.; Portelius, E.; Wirths, O.   & Heywood, W. et al.​ (2018) 
    Acta Neuropathologica Communications, 6(1) art. 62​.​ DOI: https://doi.org/10.1186/s40478-018-0563-8 
    ​Details  DOI 
  • 2018 | Journal Article | 
    ​ ​A two-step immunoassay for the simultaneous assessment of Aβ38, Aβ40 and Aβ42 in human blood plasma supports the Aβ42/Aβ40 ratio as a promising biomarker candidate of Alzheimer’s disease​
    Shahpasand-Kroner, H.; Klafki, H.-W.; Bauer, C.; Schuchhardt, J.; Hüttenrauch, M.; Stazi, M. & Bouter, C. et al.​ (2018) 
    Alzheimer's Research & Therapy, 10(1) art. 121​.​ DOI: https://doi.org/10.1186/s13195-018-0448-x 
    ​Details  DOI 
  • 2018 | Journal Article | 
    ​ ​Synergistic Effect on Neurodegeneration by N-Truncated Aβ4-42 and Pyroglutamate Aβ3-42 in a Mouse Model of Alzheimer's Disease.​
    Lopez-Noguerola, J. S.; Giessen, N. M. E.; Ueberück, M.; Meißner, J. N.; Pelgrim, C. E.; Adams, J. & Wirths, O.  et al.​ (2018) 
    Frontiers in aging neuroscience, 10 art. 64​.​ DOI: https://doi.org/10.3389/fnagi.2018.00064 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article
    ​ ​Altered neurogenesis in mouse models of Alzheimer disease​
    Wirths, O. ​ (2017) 
    Neurogenesis (Austin, Tex.), 4(1) pp. e1327002​.​ DOI: https://doi.org/10.1080/23262133.2017.1327002 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article
    ​ ​Extraction of Soluble and Insoluble Protein Fractions from Mouse Brains and Spinal Cords​
    Wirths, O. ​ (2017) 
    BIO-PROTOCOL, 7(15).​ DOI: https://doi.org/10.21769/BioProtoc.2422 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Preparation of Crude Synaptosomal Fractions from Mouse Brains and Spinal Cords​
    Wirths, O. ​ (2017) 
    BIO-PROTOCOL, 7(15).​ DOI: https://doi.org/10.21769/BioProtoc.2423 
    ​Details  DOI 
  • 2017 | Journal Article | 
    ​ ​N-truncated Aβ4–x peptides in sporadic Alzheimer’s disease cases and transgenic Alzheimer mouse models​
    Wirths, O. ; Walter, S.; Kraus, I. ; Klafki, H. W. ; Stazi, M.; Oberstein, T. J. & Ghiso, J. et al.​ (2017) 
    Alzheimer's Research & Therapy, 9(1) art. 80​.​ DOI: https://doi.org/10.1186/s13195-017-0309-z 
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​Endogenous Apolipoprotein E (ApoE) Fragmentation Is Linked to Amyloid Pathology in Transgenic Mouse Models of Alzheimer’s Disease​
    Saul, A.   & Wirths, O. ​ (2016) 
    Molecular Neurobiology, 54(1) pp. 319​-327​.​ DOI: https://doi.org/10.1007/s12035-015-9674-4 
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​Limited Effects of Prolonged Environmental Enrichment on the Pathology of 5XFAD Mice​
    Hüttenrauch, M. ; Walter, S.; Kaufmann, M.; Weggen, S. & Wirths, O. ​ (2016) 
    Molecular Neurobiology, 54(8) pp. 6542​-6555​.​ DOI: https://doi.org/10.1007/s12035-016-0167-x 
    ​Details  DOI 
  • 2016 | Journal Article | 
    ​ ​Physical activity delays hippocampal neurodegeneration and rescues memory deficits in an Alzheimer disease mouse model​
    Hüttenrauch, M. ; Brauß, A.; Kurdakova, A.; Borgers, H.; Klinker, F. ; Liebetanz, D.   & Salinas-Riester, G.  et al.​ (2016) 
    Translational Psychiatry, 6(5) art. e800​.​ DOI: https://doi.org/10.1038/tp.2016.65 
    ​Details  DOI 
  • 2016 | Journal Article | 
    ​ ​Deposition of C-terminally truncated Aβ species Aβ37 and Aβ39 in Alzheimer’s disease and transgenic mouse models​
    Reinert, J. ; Richard, B. C. ; Klafki, H. W. ; Friedrich, B.; Bayer, T. A. ; Wiltfang, J.   & Kovacs, G. G. et al.​ (2016) 
    Acta Neuropathologica Communications, 4(1) art. 24​.​ DOI: https://doi.org/10.1186/s40478-016-0294-7 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article | 
    ​ ​The Cannabinoid CB1/CB2 Agonist WIN55212.2 Promotes Oligodendrocyte Differentiation In Vitro and Neuroprotection During the Cuprizone-Induced Central Nervous System Demyelination​
    Tomas-Roig, J.; Wirths, O. ; Salinas-Riester, G. & Havemann-Reinecke, U.​ (2016) 
    CNS Neuroscience & Therapeutics, 22(5) pp. 387​-395​.​ DOI: https://doi.org/10.1111/cns.12506 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | 
    ​ ​Phosphorylation of the amyloid beta-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity​
    Kumar, S.; Wirths, O. ; Stueber, K.; Wunderlich, P.; Koch, P.; Theil, S. & Rezaei-Ghaleh, N. et al.​ (2016) 
    Acta Neuropathologica, 131(4) pp. 525​-537​.​ DOI: https://doi.org/10.1007/s00401-016-1546-0 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | 
    ​ ​Effects of Long-Term Environmental Enrichment on Anxiety, Memory, Hippocampal Plasticity and Overall Brain Gene Expression in C57BL6 Mice​
    Huettenrauch, M.; Salinas, G. & Wirths, O. ​ (2016) 
    Frontiers in Molecular Neuroscience, 9 art. 62​.​ DOI: https://doi.org/10.3389/fnmol.2016.00062 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article
    ​ ​N-Truncated Aβ2-X Starting with Position Two in Sporadic Alzheimer’s Disease Cases and Two Alzheimer Mouse Models​
    Savastano, A. ; Klafki, H. ; Haußmann, U.; Oberstein, T. J.; Muller, P.; Wirths, O.   & Wiltfang, J.  et al.​ (2015) 
    Journal of Alzheimer's Disease, 49(1) pp. 101​-110​.​ DOI: https://doi.org/10.3233/jad-150394 
    ​Details  DOI 
  • 2015 | Journal Article
    ​ ​Neprilysin Deficiency Alters the Neuropathological and Behavioral Phenotype in the 5XFAD Mouse Model of Alzheimer's Disease​
    Huettenrauch, M.; Baches, S.; Gerth, J.; Bayer, T. A.; Weggen, S. & Wirths, O. ​ (2015) 
    Journal of Alzheimer s Disease, 44(4) pp. 1291​-1302​.​ DOI: https://doi.org/10.3233/JAD-142463 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | 
    ​ ​N-truncated Abeta starting with position four: early intraneuronal accumulation and rescue of toxicity using NT4X-167, a novel monoclonal antibody​
    Antonios, G.; Saiepour, N. ; Bouter, Y. ; Richard, B. C. ; Paetau, A.; Verkkoniemi-Ahola, A. & Lannfelt, L. et al.​ (2013) 
    Acta Neuropathologica Communications, 1(1) art. 56​.​ DOI: https://doi.org/10.1186/2051-5960-1-56 
    ​Details  DOI  PMID  PMC 
  • 2008 | Journal Article | Research Paper | 
    ​ ​Early Intraneuronal Beta-Amyloid Pathology: Do Transgenic Mice Represent Valid Model Systems?​
    Wirths, O.   & Bayer, T. A. ​ (2008) 
    Open Longevity Science, 2 pp. 7​-12​.​ DOI: https://doi.org/10.2174/1876326X00802010007 
    ​Details  DOI 

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