Prof. Dr. med. Matthias Dobbelstein

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  • 2023 | Journal Article | 
    ​ ​N4-hydroxycytidine, the active compound of Molnupiravir, promotes SARS-CoV-2 mutagenesis and escape from a neutralizing nanobody​
    Zibat, A.; Zhang, X.; Dickmanns, A.; Stegmann, K. M.; Dobbelstein, A. W.; Alachram, H. & Soliwoda, R. et al.​ (2023) 
    iScience, 26(10) art. 107786​.​ DOI: https://doi.org/10.1016/j.isci.2023.107786 
    ​Details  DOI 
  • 2022 | Journal Article | Research Paper | 
    ​ ​MDM2 binds and ubiquitinates PARP1 to enhance DNA replication fork progression​
    Giansanti, C.; Manzini, V.; Dickmanns, A.; Dickmanns, A. ; Palumbieri, M. D.; Sanchi, A. & Kienle, S. M. et al.​ (2022) 
    Cell Reports, 39(9) art. 110879​.​ DOI: https://doi.org/10.1016/j.celrep.2022.110879 
    ​Details  DOI 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Inhibitors of dihydroorotate dehydrogenase cooperate with molnupiravir and N4-hydroxycytidine to suppress SARS-CoV-2 replication​
    Stegmann, K. M.; Dickmanns, A.; Heinen, N.; Blaurock, C.; Karrasch, T.; Breithaupt, A. & Klopfleisch, R. et al.​ (2022) 
    iScience, 25(5) art. S2589004222005636​.​ DOI: https://doi.org/10.1016/j.isci.2022.104293 
    ​Details  DOI 
  • 2021 | Journal Article
    ​ ​The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models​
    Stegmann, K. M.; Dickmanns, A.; Gerber, S.; Nikolova, V.; Klemke, L.; Manzini, V. & Schlösser, D. et al.​ (2021) 
    Virus Research, 302 art. S0168170221001763​.​ DOI: https://doi.org/10.1016/j.virusres.2021.198469 
    ​Details  DOI 
  • 2021 | Journal Article | 
    ​ ​Neutralization of SARS‐CoV‐2 by highly potent, hyperthermostable, and mutation‐tolerant nanobodies​
    Güttler, T.; Aksu, M.; Dickmanns, A.; Stegmann, K. M.; Gregor, K.; Rees, R. & Taxer, W. et al.​ (2021) 
    The EMBO Journal, 40(19).​ DOI: https://doi.org/10.15252/embj.2021107985 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis​
    Müller, A.; Dickmanns, A.; Resch, C.; Schäkel, K.; Hailfinger, S.; Dobbelstein, M.   & Schulze-Osthoff, K. et al.​ (2020) 
    Journal of Clinical Investigation, 130(11) pp. 5765​-5781​.​ DOI: https://doi.org/10.1172/JCI134217 
    ​Details  DOI 
  • 2018 | Journal Article | 
    ​ ​CDK4 inhibition diminishes p53 activation by MDM2 antagonists​
    Sriraman, A.; Dickmanns, A.; Najafova, Z.; Johnsen, S. A. & Dobbelstein, M. ​ (2018) 
    Cell Death & Disease, 9(9) art. 918​.​ DOI: https://doi.org/10.1038/s41419-018-0968-0 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article
    ​ ​MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53​
    Wienken, M.; Dickmanns, A.; Nemajerova, A.; Kramer, D.; Najafova, Z.; Weiss, M. & Karpiuk, O. et al.​ (2016) 
    Molecular Cell, 61(1) pp. 68​-83​.​ DOI: https://doi.org/10.1016/j.molcel.2015.12.008 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article
    ​ ​p63 antagonizes Wnt-induced transcription​
    Drewelus, I.; Göpfert, C.; Hippel, C.; Dickmanns, A.; Damianitsch, K.; Pieler, T. & Dobbelstein, M. ​ (2010) 
    Cell Cycle, 9(3) pp. 580​-587​.​
    ​Details  PMID  PMC  WoS 

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