Prof. Dr. med. Jens M. Schmidt

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  • 2022 Journal Article | Research Paper | 
    ​ ​Meyer, Stefanie, Silke Kaulfuß, Sabrina Zechel, Karsten Kummer, Ali Seif Amir Hosseini, Marielle Sophie Ernst, Jens Schmidt, Silke Pauli, and Jana Zschüntzsch. "Evidence of Two Novel LAMA2 Variants in a Patient With Muscular Dystrophy: Facing the Challenges of a Certain Diagnosis​." ​Frontiers in Neurology ​13 (2022): . ​https://doi.org/10.3389/fneur.2022.893605.
    Details  DOI 
  • 2022 Journal Article | Editorial Contribution (Editorial, Introduction, Epilogue)
    ​ ​Schmidt, Jens M., Peter Korsten, Sabrina Zechel, and Silke Schlüter. "Introducing the international Myositis Society (iMyoS): a novel multiprofessional society to foster the care, education, and research on myositis​." ​Clinical and Experimental Rheumatology ​40, no. 2 (2022): ​210​-213​. ​https://doi.org/10.55563/clinexprheumatol/1a7tkf.
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  • 2022 Journal Article
    ​ ​Glaubitz, Stefanie, Rachel Zeng, Goran Rakocevic, and Jens Schmidt. "Update on Myositis Therapy: From Today’s Standards to Tomorrow’s Possibilities​." ​Current Pharmaceutical Design ​28, no. 11 (2022): ​863​-880​. ​https://doi.org/10.2174/1381612827666211115165353.
    Details  DOI 
  • 2022 Journal Article | 
    ​ ​Merckx, Caroline, Jana Zschüntzsch, Stefanie Meyer, Robrecht Raedt, Hanne Verschuere, Jens Schmidt, Boel De Paepe, and Jan L. De Bleecker. "Exploring the Therapeutic Potential of Ectoine in Duchenne Muscular Dystrophy: Comparison with Taurine, a Supplement with Known Beneficial Effects in the mdx Mouse​." ​International Journal of Molecular Sciences ​23, no. 17 (2022): ​9567​. ​https://doi.org/10.3390/ijms23179567.
    Details  DOI 
  • 2021 Journal Article | 
    ​ ​Korsten, Peter, Jan-Gerd Rademacher, Linn Riedel, Eva-Maria Schnitzler, Ulrike Olgemöller, Cornelia Sabine Seitz, Jens Schmidt, Jörg Larsen, and Radovan Vasko. "Antisynthetase Syndrome-Associated Interstitial Lung Disease: Monitoring of Immunosuppressive Treatment Effects by Chest Computed Tomography​." ​Frontiers in Medicine ​7 (2021): . ​https://doi.org/10.3389/fmed.2020.609595.
    Details  DOI 
  • 2021 Journal Article | 
    ​ ​Fitzner, Maren, and Jens Schmidt. "Ursache von Muskelschwäche: Spektrum neuromuskulärer Erkrankungen und diagnostisches Vorgehen​." ​Aktuelle Rheumatologie ​46, no. 04 (2021): ​373​-381​. ​https://doi.org/10.1055/a-1548-8821.
    Details  DOI 
  • 2020 Journal Article
    ​ ​Glaubitz, Stefanie, Rachel Zeng, and Jens Schmidt. "New insights into the treatment of myositis​." ​Therapeutic Advances in Musculoskeletal Disease ​12 (2020): ​1759720X1988649​. ​https://doi.org/10.1177/1759720X19886494.
    Details  DOI 
  • 2020 Journal Article
    ​ ​Prukop, Thomas, Stephanie Wernick, Lydie Boussicault, David Ewers, Karoline Jäger, Julia Adam, Lorenz Winter et al. "Synergistic PXT3003 therapy uncouples neuromuscular function from dysmyelination in male Charcot–Marie–Tooth disease type 1A (CMT1A) rats​." ​Journal of Neuroscience Research ​98, no. 10 (2020): ​1933​-1952​. ​https://doi.org/10.1002/jnr.24679.
    Details  DOI 
  • 2020 Journal Article
    ​ ​Zeng, Rachel, and Jens Schmidt. "Impact and Management of Dysphagia in Inflammatory Myopathies​." ​Current Rheumatology Reports ​22, no. 10 (2020): . ​https://doi.org/10.1007/s11926-020-00950-3.
    Details  DOI 
  • 2020 Journal Article | 
    ​ ​Dohrn, Maike F., Michaela Auer-Grumbach, Ralf Baron, Frank Birklein, Fabiola Escolano-Lozano, Christian Geber, Nicolai Grether et al. "Chance or challenge, spoilt for choice? New recommendations on diagnostic and therapeutic considerations in hereditary transthyretin amyloidosis with polyneuropathy: the German/Austrian position and review of the literature​." ​Journal of Neurology (2020): . ​https://doi.org/10.1007/s00415-020-09962-6.
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  • 2020 Journal Article | Research Paper | 
    ​ ​Zschüntzsch, Jana, Pia Vanessa Jouvenal, Yaxin Zhang, Florian Klinker, Malte Tiburcy, David Liebetanz, Dörthe Malzahn, Heinrich Brinkmeier, and Jens Schmidt. "Long‐term human IgG treatment improves heart and muscle function in a mouse model of Duchenne muscular dystrophy​." ​Journal of Cachexia, Sarcopenia and Muscle ​11, no. 4 (2020): ​1018​-1031​. ​https://doi.org/10.1002/jcsm.12569.
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  • 2020 Journal Article | 
    ​ ​Korsten, Peter, Jens M. Schmidt, Jörg Larsen, and Cornelia Sabine Seitz. "Mechanic's hands in a patient with isolated anti-Ro52 antibodies: antisynthetase syndrome without antisynthetase antibodies​." ​Journal der Deutschen Dermatologischen Gesellschaft ​18, no. 2 (2020): ​147​-148​. ​https://doi.org/10.1111/ddg.13985.
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  • 2019 Journal Article
    ​ ​Korsten, Peter, Cornelia S Seitz, Carsten O Sahlmann, and Jens Schmidt. "Comment on: The temporal relationship between cancer and adult onset anti-transcriptional intermediary factor 1 antibody–positive dermatomyositis​." ​Rheumatology ​58, no. 11 (2019): ​2071​-2073​. ​https://doi.org/10.1093/rheumatology/kez313.
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  • 2019 Journal Article
    ​ ​Glaubitz, Stefanie, Karsten Schmidt, Jana Zschüntzsch, and Jens Schmidt. "Myalgia in myositis and myopathies​." ​Best Practice & Research. Clinical Rheumatology ​33, no. 3 (2019): ​101433​. ​https://doi.org/10.1016/j.berh.2019.101433.
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  • 2019 Journal Article
    ​ ​Schmidt, Jens. "Endpoint choice for inclusion body myositis: a step too far?​." ​The Lancet Neurology ​18, no. 9 (2019): ​807​-808​. ​https://doi.org/10.1016/S1474-4422(19)30279-0.
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  • 2019 Journal Article | 
    ​ ​Capkun, Gorana, Jens Schmidt, Shubhro Ghosh, Harsh Sharma, Thomas Obadia, Ana de Vera, Valery Risson, and Billy Amzal. "Development and validation of a Bayesian survival model for inclusion body myositis​." ​Theoretical Biology and Medical Modelling ​16, no. 1 (2019): . ​https://doi.org/10.1186/s12976-019-0114-4.
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  • 2019 Journal Article | 
    ​ ​Carstens, Per-Ole, Eva Maria Christina Schwaibold, Katharina Schregel, Carolin D. Obermaier, Arne Wrede, Sabrina Zechel, Silke Pauli, and Jens Schmidt. "X-linked myotubular myopathy and recurrent spontaneous pneumothorax: A new phenotype?​." ​Neurology Genetics ​5, no. 3 (2019): ​e327​. ​https://doi.org/10.1212/NXG.0000000000000327.
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  • 2018 Journal Article
    ​ ​De Paepe, Boel, Jana Zschüntzsch, Tea Šokčević, Joachim Weis, Jens Schmidt, and Jan L. De Bleecker. "Induction of Osmolyte Pathways in Skeletal Muscle Inflammation: Novel Biomarkers for Myositis​." ​Frontiers in Neurology ​9 (2018): . ​https://doi.org/10.3389/fneur.2018.00846.
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  • 2018 Journal Article
    ​ ​Miller, Frederick W., Janine A. Lamb, Jens Schmidt, and Kanneboyina Nagaraju. "Risk factors and disease mechanisms in myositis​." ​Nature Reviews. Rheumatology ​14, no. 5 (2018): ​255​-268​. ​https://doi.org/10.1038/nrrheum.2018.48.
    Details  DOI 
  • 2018 Journal Article | 
    ​ ​Herbelet, Sandrine, Elly De Vlieghere, Amanda Gonçalves, Boel De Paepe, Karsten Schmidt, Eline Nys, Laurens Weynants et al. "Localization and Expression of Nuclear Factor of Activated T-Cells 5 in Myoblasts Exposed to Pro-inflammatory Cytokines or Hyperosmolar Stress and in Biopsies from Myositis Patients​." ​Frontiers in Physiology ​9 (2018): . ​https://doi.org/10.3389/fphys.2018.00126.
    Details  DOI 
  • 2017 Journal Article
    ​ ​Schmidt, Karsten, and Jens Schmidt. "Inclusion body myositis​." ​Current Opinion in Rheumatology ​29, no. 6 (2017): ​632​-638​. ​https://doi.org/10.1097/BOR.0000000000000436.
    Details  DOI 
  • 2017 Journal Article
    ​ ​Smogavec, Mateja, Jana Zschüntzsch, Wolfram Kress, Julia Mohr, Peter Hellen, Barbara Zoll, Silke Pauli, and Jens Schmidt. "Novel fukutin mutations in limb-girdle muscular dystrophy type 2M with childhood onset​." ​Neurology Genetics ​3, no. 4 (2017): ​e167​. ​https://doi.org/10.1212/NXG.0000000000000167.
    Details  DOI 
  • 2017 Journal Article
    ​ ​Lilleker, James B, Jiri Vencovsky, Guochun Wang, Lucy R Wedderburn, Louise P Diederichsen, Jens Schmidt, Paula Jordan et al. "Response to: ‘Antisynthetase syndrome or what else? Different perspectives indicate the need for new classification criteria’ by Cavagna et al​." ​Annals of the Rheumatic Diseases (2017): ​annrheumdis-2017-212382​. ​https://doi.org/10.1136/annrheumdis-2017-212382.
    Details  DOI 
  • 2017 Review | 
    ​ ​Fitzner, Maren, and Jens Schmidt. "Inflammatory Muscle Disorders - State of the Art of Diagnosis and Treatment of Myositis​." Physikalische Medizin Rehabilitationsmedizin Kurortmedizin ​27​, no. 1​ (2017): ​23​-34​. ​https://doi.org/10.1055/s-0042-123877.
    Details  DOI  WoS 
  • 2017 Journal Article | 
    ​ ​Schmidt, Karsten, Magdalena Wienken, Christian W. Keller, Peter Balcarek, Christian Münz, and Jens Schmidt. "IL-1 beta-Induced Accumulation of Amyloid: Macroautophagy in Skeletal Muscle Depends on ERK​." ​Mediators of Inflammation (2017): ​5470831​. ​https://doi.org/10.1155/2017/5470831.
    Details  DOI  WoS 
  • 2016 Journal Article | Letter Note
    ​ ​Sunderkoetter, Cord, Alexander Nast, Margitta Worm, Reinhard Dengler, Thomas Doerner, Horst Ganter, Reinhard Hohlfeld et al. "Guidelines on dermatomyositis excerpt from the interdisciplinary S2k guidelines on myositis syndromes by the German Society of Neurology​." ​JDDG Journal der Deutschen Dermatologischen Gesellschaft ​14, no. 3 (2016): ​321​-333​. ​https://doi.org/10.1111/ddg.12909.
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  • 2016 Journal Article
    ​ ​Zschuentzsch, Jana, Y. Zhang, Florian Klinker, Gregor Makosch, Lars Klinge, Doerthe Malzahn, Heinrich Brinkmeier, David Liebetanz, and Jens Schmidt. "Treatment with human immunoglobulin G improves the early disease course in a mouse model of Duchenne muscular dystrophy​." ​Journal of Neurochemistry ​136, no. 2 (2016): ​351​-362​. ​https://doi.org/10.1111/jnc.13269.
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  • 2016 Journal Article
    ​ ​Stoeck, Katharina, Marios Nikos Psychogios, Andreas Ohlenbusch, Robert Steinfeld, and Jens Schmidt. "Late-Onset Metachromatic Leukodystrophy with Early Onset Dementia Associated with a Novel Missense Mutation in the Arylsulfatase A Gene​." ​Journal of Alzheimer's Disease ​51, no. 3 (2016): ​683​-687​. ​https://doi.org/10.3233/JAD-150819.
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  • 2016 Journal Article | 
    ​ ​Jones, Katherine L., Thomas Sejersen, Anthony A. Amato, David Hilton-Jones, Jens Schmidt, Amanda C. Wallace, Umesh A. Badrising, and Michael R. Rose. "A PROTOCOL TO DEVELOP CLINICAL GUIDELINES FOR INCLUSION-BODY MYOSITIS​." ​Muscle & Nerve ​53, no. 4 (2016): ​503​-507​. ​https://doi.org/10.1002/mus.25036.
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  • 2016 Journal Article | 
    ​ ​Schmidt, Karsten, Konstanze Kleinschnitz, Goran Rakocevic, Marinas C. Dalakas, and Jens Schmidt. "Molecular treatment effects of alemtuzumab in skeletal muscles of patients with IBM​." ​BMC Neurology ​16 (2016): ​48​. ​https://doi.org/10.1186/s12883-016-0568-5.
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  • 2016 Journal Article
    ​ ​Olthoff, Arno, Per-Ole Carstens, Shuo Zhang, Eva von Fintel, Tim Friede, Joachim Lotz, Jens Frahm, and Jens Schmidt. "Evaluation of dysphagia by novel real-time MRI​." ​Neurology ​87, no. 20 (2016): ​2132​-2138​. ​https://doi.org/10.1212/WNL.0000000000003337.
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  • 2016 Journal Article | Letter Note
    ​ ​Dalakas, Marinas C., and Jens Schmidt. "Viruses in IBM Hit-and-run, hide and persist, or irrelevant?​." ​Neurology ​86, no. 3 (2016): ​204​-205​. ​https://doi.org/10.1212/WNL.0000000000002295.
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  • 2015 Journal Article
    ​ ​Wiederschein, F., E. Vöhringer-Martinez, A. Beinsen, F. Postberg, J. Schmidt, R. Srama, F. Stolz, H. Grubmüller, and B. Abel. "Charge separation and isolation in strong water droplet impacts​." ​Physical Chemistry Chemical Physics ​17, no. 10 (2015): ​6858​-6864​. ​https://doi.org/10.1039/C4CP05618C.
    Details  DOI 
  • 2015 Journal Article
    ​ ​Muth, Ingrid E., Jana Zschuentzsch, Konstanze Kleinschnitz, Arne Wrede, Ellen Gerhardt, Peter Balcarek, Olivia Schreiber-Katz et al. "HMGB1 and RAGE in skeletal muscle inflammation: Implications for protein accumulation in inclusion body myositis​." ​Experimental Neurology ​271 (2015): ​189​-197​. ​https://doi.org/10.1016/j.expneurol.2015.05.023.
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  • 2014 Conference Abstract
    ​ ​Muth, Ingrid E., Konstanze Kleinschnitz, Peter Balcarek, Arne Wrede, Olivia Schreiber, Stephan Zierz, Marinas C. Dalakas, Reinhard E. Voll, and Jens Schmidt. "HMGB1 and RAGE in skeletal muscle inflammation: Implications for protein accumulation in inclusion body myositis (IBM)​." ​Journal of Neuroimmunology ​275​, ​no. 1-2 (2014): https://doi.org/10.1016/j.jneuroim.2014.08.186.
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  • 2014 Conference Abstract
    ​ ​Schmidt, Karsten, Konstanze Kleinschnitz, Goran Rakocevic, Marinas C. Dalakas, and Jens Schmidt. "Treatment of IBM with alemtuzumab: Molecular treatment effects in skeletal muscle​." ​Journal of Neuroimmunology ​275​, ​no. 1-2 (2014): https://doi.org/10.1016/j.jneuroim.2014.08.604.
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  • 2014 Conference Abstract
    ​ ​Haas, Christina, Jana Zschüntzsch, Sven Thoms, and Jens Schmidt. "Endoplasmic reticulum stress induced by inflammation in skeletal muscle cells is associated with protein accumulation and reduced by methylene blue: Implications for inclusion body myositis​." ​Journal of Neuroimmunology ​275​, ​no. 1-2 (2014): https://doi.org/10.1016/j.jneuroim.2014.08.161.
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  • 2014 Review
    ​ ​Breithaupt, Maren, and Jens Schmidt. "Treatment strategies for inclusion body myositis​." Expert Opinion on Orphan Drugs ​2​, no. 12​ (2014): ​1255​-1265​. ​https://doi.org/10.1517/21678707.2014.966688.
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  • 2013 Journal Article
    ​ ​Keller, Christian W., Matthias Schmitz, Christian Münz, Jan D. Luenemann, and Jens Schmidt. "TNF-alpha upregulates macroautophagic processing of APP/beta-amyloid in a human rhabdomyosarcoma cell line​." ​Journal of the Neurological Sciences ​325, no. 1-2 (2013): ​103​-107​. ​https://doi.org/10.1016/j.jns.2012.12.011.
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  • 2013 Review
    ​ ​Schmidt, Jens, and Marinas C. Dalakas. "Inclusion body myositis: from immunopathology and degenerative mechanisms to treatment perspectives​." Expert Review of Clinical Immunology ​9​, no. 11​ (2013): ​1125​-1133​. ​https://doi.org/10.1586/1744666X.2013.842467.
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  • 2013 Journal Article
    ​ ​Breithaupt, Maren, and Jens Schmidt. "Update on Treatment of Inclusion Body Myositis​." ​Current Rheumatology Reports ​15, no. 5 (2013): ​329​. ​https://doi.org/10.1007/s11926-013-0329-z.
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  • 2013 Journal Article | 
    ​ ​Fischer, Charlotte, Konstanze Kleinschnitz, Arne Wrede, Ingrid E. Muth, Niels Kruse, Ichizo Nishino, and Jens Schmidt. "Cell stress molecules in the skeletal muscle of GNE myopathy​." ​BMC Neurology ​13 (2013): ​24​. ​https://doi.org/10.1186/1471-2377-13-24.
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  • 2012 Conference Abstract
    ​ ​Schmidt, Jens. "Inclusion body myositis: Nitric oxide mediates inflammatory cell stress in skeletal muscle​." ​Journal of Neuroimmunology ​253​, ​no. 1-2 (2012): ​55​-56. 
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  • 2012 Conference Abstract
    ​ ​Zschuentzsch, Jana, Charlotte Weller, Y. Zhang, Florian Klinker, Gregor Makosch, Lars Klinge, Josbert M. Metselaar, David Liebetanz, Heinrich Brinkmeier, and Jens Schmidt. "Human IgG but not liposomal prednisolone improves the early clinical course of mdx mice as model for Duchenne muscular dystrophy​." ​Journal of Neuroimmunology ​253​, ​no. 1-2 (2012): ​177​-178. 
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  • 2012 Journal Article
    ​ ​Weller, Charlotte, Jana Zschuentzsch, Gregor Makosch, Josbert M. Metselaar, Florian Klinker, Lars Klinge, David Liebetanz, and Jens Schmidt. "Motor performance of young dystrophic mdx mice treated with long-circulating prednisolone liposomes​." ​Journal of Neuroscience Research ​90, no. 5 (2012): ​1067​-1077​. ​https://doi.org/10.1002/jnr.22825.
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  • 2012 Journal Article
    ​ ​Zschuentzsch, Jana, Joachim Voss, Kim Creus, Stephan Sehmisch, Raghavan Raju, Marinas C. Dalakas, and Jens Schmidt. "Provision of an Explanation for the Inefficacy of Immunotherapy in Sporadic Inclusion Body Myositis Quantitative Assessment of Inflammation and beta-Amyloid in the Muscle​." ​Arthritis & Rheumatism ​64, no. 12 (2012): ​4094​-4103​. ​https://doi.org/10.1002/art.37692.
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  • 2012 Journal Article
    ​ ​Schmidt, Jens, Konstanze Barthel, Jana Zschuentzsch, Ingrid E. Muth, Emily J. Swindle, Anja Hombach, Stephan Sehmisch et al. "Nitric oxide stress in sporadic inclusion body myositis muscle fibres: inhibition of inducible nitric oxide synthase prevents interleukin-1 beta-induced accumulation of beta-amyloid and cell death​." ​Brain ​135 (2012): ​1102​-1114​. ​https://doi.org/10.1093/brain/aws046.
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  • 2011 Journal Article
    ​ ​Keller, Christian W., Claudia Fokken, Stuart G. Turville, Anna Luenemann, Jens Schmidt, Christian Münz, and Jan D. Luenemann. "TNF-alpha Induces Macroautophagy and Regulates MHC Class II Expression in Human Skeletal Muscle Cells​." ​Journal of Biological Chemistry ​286, no. 5 (2011): ​3970​-3980​. ​https://doi.org/10.1074/jbc.M110.159392.
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  • 2009 Journal Article | Letter Note
    ​ ​Schmidt, Jens, and Marinas C. Dalakas. "Inflammation interrelates to APP in sIBM: IL-1 induces accumulation of amyloid​." ​Brain ​132 (2009): ​e107​. ​https://doi.org/10.1093/brain/awn164.
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  • 2009 Journal Article | Research Paper
    ​ ​Muth, I. E., Konstanze Barthel, Mathias Bähr, M. C. Dalakas, and J. Schmidt. "Proinflammatory cell stress in sporadic inclusion body myositis muscle: overexpression of alpha B-crystallin is associated with amyloid precursor protein and accumulation of beta-amyloid​." ​Journal of Neurology, Neurosurgery & Psychiatry ​80, no. 12 (2009): ​1344​-1349​. ​https://doi.org/10.1136/jnnp.2009.174276.
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  • 2008 Conference Abstract
    ​ ​Keller, Christian W., Monica Lee, Stuart G. Turville, Anna Lunemann, Jens Schmidt, Christian Münz, and Jan D. Luenemann. "TNF-alpha induces macroautophagy and regulates MHC class II expression in human skeletal myocytes​." ​Journal of Neuroimmunology ​203​, ​no. 2 (2008): 
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  • 2008 Journal Article
    ​ ​Linker, Ralf A., Charlotte Weller, Fred Luehder, Alexander Mohr, Jens Schmidt, Michael Knauth, Josbert M. Metselaar, and Ralf Gold. "Liposomal glucocorticosteroids in treatment of chronic autoimmune demyelination: Long-term protective effects and enhanced efficacy of methylprednisolone formulations​." ​Experimental Neurology ​211, no. 2 (2008): ​397​-406​. ​https://doi.org/10.1016/j.expneurol.2008.02.005.
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  • 2008 Journal Article | Research Paper | 
    ​ ​Schmidt, Jens, Konstanze Barthel, Arne Wrede, Mohammad Salajegheh, Mathias Bähr, and Marinos C. Dalakas. "Interrelation of inflammation and APP in sIBM: IL-1 beta induces accumulation of beta-amyloid in skeletal muscle​." ​Brain ​131, no. 5 (2008): ​1228​-1240​. ​https://doi.org/10.1093/brain/awn053.
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  • 2007 Journal Article
    ​ ​Lunemann, Jan D., Jens Schmidt, Marinas C. Dalakas, and Christian Münz. "Macroautophagy as a pathomechanism in sporadic inclusion body myositis​." ​Autophagy ​3, no. 4 (2007): ​384​-386​. ​
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  • 2007 Journal Article
    ​ ​Salajegheh, Mohammad, Raghavan Raju, Jens Schmidt, and Marinas C. Dalakas. "Upregulation of thrombospondin-1(TSP-1) and its binding partners, CD36 and CD47, in sporadic inclusion body myositis​." ​Journal of Neuroimmunology ​187, no. 1-2 (2007): ​166​-174​. ​https://doi.org/10.1016/j.jneuroim.2007.04.022.
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  • 2007 Journal Article
    ​ ​Lunemann, Jan D., Jens Schmidt, Dorothee Schmid, Konstanze Barthel, Arne Wrede, Marinas C. Dalakas, and Christian Münz. "beta-amyloid is a substrate of autophagy in sporadic inclusion body myositis​." ​Annals of Neurology ​61, no. 5 (2007): ​476​-483​. ​https://doi.org/10.1002/ana.21115.
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