Prof. Dr. med. Jochen Gaedcke

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  • 2023 Journal Article | 
    ​ ​Rühlmann F, Hedicke MS, Engelhardt D, Mackert AF, Tichelbäcker T, Leha A, et al. ​Incidence and impact of new-onset postoperative arrhythmia after surgery of the lower gastrointestinal tract​. ​​Scientific Reports. ​2023;​13​(1). ​doi:10.1038/s41598-023-27508-4. 
    Details  DOI 
  • 2022 Journal Article | Research Paper | 
    ​ ​Bremer SCB, Bittner G, Elakad O, Dinter H, Gaedcke J, König AO, et al. ​Enhancer of Zeste Homolog 2 (EZH2) Is a Marker of High-Grade Neuroendocrine Neoplasia in Gastroenteropancreatic and Pulmonary Tract and Predicts Poor Prognosis​. ​​Cancers. ​2022;​14​(12):​​2828​. ​doi:10.3390/cancers14122828. 
    Details  DOI 
  • 2021 Journal Article | 
    ​ ​De Oliveira T, Goldhardt T, Edelmann M, Rogge T, Rauch K, Kyuchukov ND, et al. ​Effects of the Novel PFKFB3 Inhibitor KAN0438757 on Colorectal Cancer Cells and Its Systemic Toxicity Evaluation In Vivo​. ​​Cancers. ​2021;​13​(5):​​1011​. ​doi:10.3390/cancers13051011. 
    Details  DOI 
  • 2021 Journal Article | 
    ​ ​Koerdel K, Spitzner M, Meyer T, Engels N, Krause F, Gaedcke J, et al. ​NOTCH Activation via gp130/STAT3 Signaling Confers Resistance to Chemoradiotherapy​. ​​Cancers. ​2021;​13​(3):​​455​. ​doi:10.3390/cancers13030455. 
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  • 2020 Journal Article
    ​ ​Dusch N, Oldani M, Steffen T, Kitz J, Koenig U, Azizian A, et al. ​Intensified Histopathological Work-Up after Pancreatic Head Resection Reveals Relevant Prognostic Markers​. ​​Digestion. ​2020;:​​1​-9​. ​doi:10.1159/000504648. 
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  • 2020 Journal Article
    ​ ​Patil S, Steuber B, Kopp W, Kari V, Urbach L, Wang X, et al. ​EZH2 Regulates Pancreatic Cancer Subtype Identity and Tumor Progression via Transcriptional Repression of GATA6​. ​​Cancer Research. ​2020;​80​(21):​​4620​-4632​. ​doi:10.1158/0008-5472.CAN-20-0672. 
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  • 2020 Journal Article
    ​ ​Bartsch F, Eberhard J, Rückert F, Schmelzle M, Lehwald‐Tywuschik N, Fichtner‐Feigl S, et al. ​Repeated resection for recurrent intrahepatic cholangiocarcinoma: A retrospective German multicentre study​. ​​Liver International. ​2020;​41​(1):​​180​-191​. ​doi:10.1111/liv.14682. 
    Details  DOI 
  • 2020 Journal Article | 
    ​ ​Azizian A, Rühlmann F, Krause T, Bernhardt M, Jo P, König A, et al. ​CA19-9 for detecting recurrence of pancreatic cancer​. ​​Scientific Reports. ​2020;​10​(1). ​doi:10.1038/s41598-020-57930-x. 
    Details  DOI 
  • 2020 Journal Article | 
    ​ ​Jo P, Bernhardt M, Nietert M, König A, Azizian A, Schirmer MA, et al. ​KRAS mutation status concordance between the primary tumor and the corresponding metastasis in patients with rectal cancer​. ​​PLoS One. ​2020;​15​(10):​​e0239806​. ​doi:10.1371/journal.pone.0239806. 
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  • 2019 Journal Article
    ​ ​Petrova E, Lapshyn H, Bausch D, D'Haese J, Werner J, Klier T, et al. ​Risk stratification for postoperative pancreatic fistula using the pancreatic surgery registry StuDoQ​. ​​Pancreatology. ​2019;​19​(1):​​17​-25​. ​doi:10.1016/j.pan.2018.11.008. 
    Details  DOI 
  • 2019 Journal Article
    ​ ​Bolm L, Petrova E, Woehrmann L, Werner J, Uhl W, Nuessler N, et al. ​The impact of preoperative biliary stenting in pancreatic cancer: A case-matched study from the German nationwide pancreatic surgery registry (DGAV StuDoQ​. ​​Pancreatology. ​2019;​19​(7):​​985​-993​. ​doi:10.1016/j.pan.2019.09.007. 
    Details  DOI 
  • 2019 Journal Article | 
    ​ ​Sen M, Wang X, Hamdan FH, Rapp J, Eggert J, Kosinsky RL, et al. ​ARID1A facilitates KRAS signaling-regulated enhancer activity in an AP1-dependent manner in colorectal cancer cells​. ​​Clinical Epigenetics. ​2019;​11​(1). ​doi:10.1186/s13148-019-0690-5. 
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  • 2019 Journal Article | 
    ​ ​Flebbe H, Hamdan FH, Kari V, Kitz J, Gaedcke J, Ghadimi BM, et al. ​Epigenome Mapping Identifies Tumor-Specific Gene Expression in Primary Rectal Cancer​. ​​Cancers. ​2019;​11​(8). ​doi:10.3390/cancers11081142. 
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  • 2018 Journal Article
    ​ ​Jo P, Kesruek H, Nietert M, Sahlmann C, Gaedcke J, Ghadimi M, et al. ​Inzidenz und prädiktive Faktoren des bilateralen papillären Schilddrüsenkarzinoms​. ​​Zentralblatt für Chirurgie. ​2018;​143​(04):​​361​-366​. ​doi:10.1055/a-0651-0878. 
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  • 2018 Journal Article | 
    ​ ​Wolff A, Bayerlová M, Gaedcke J, Kube D, Beißbarth T. ​A comparative study of RNA-Seq and microarray data analysis on the two examples of rectal-cancer patients and Burkitt Lymphoma cells.​. ​​PLOS ONE. ​2018;​13​(5). ​doi:10.1371/journal.pone.0197162. 
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  • 2017 Journal Article
    ​ ​Perkhofer L, Schmitt A, Romero Carrasco MC, Ihle M, Hampp S, Ruess DA, et al. ​ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage​. ​​Cancer Research. ​2017;​77​(20):​​5576​-5590​. ​doi:10.1158/0008-5472.CAN-17-0634. 
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  • 2017 Journal Article | Research Paper | 
    ​ ​Jo P, Azizian A, Salendo J, Kramer F, Bernhardt M, Wolff HA, et al. ​Changes of Microrna Levels in Plasma of Patients with Rectal Cancer during Chemoradiotherapy​. ​​International Journal of Molecular Sciences. ​2017;​18​(6). ​doi:10.3390/ijms18061140. 
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  • 2017 Journal Article
    ​ ​Chen, Nai-Ming, Neeße A, Dyck ML, Steuber B, König AO, Lubeseder-Martellato C, et al. ​Context-Dependent Epigenetic Regulation of Nuclear Factor of Activated T Cells 1 in Pancreatic Plasticity​. ​​Gastroenterology. ​2017;​152​(6):​​1507​-+​. ​doi:10.1053/j.gastro.2017.01.043. 
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  • 2017 Journal Article
    ​ ​Emons G, Spitzner M, Reineke S, Möller J, Auslander N, Kramer F, et al. ​Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-catenin Signaling​. ​​Molecular Cancer Research. ​2017;​15​(11):​​1481​-1490​. ​doi:10.1158/1541-7786.MCR-17-0205. 
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  • 2016 Conference Abstract
    ​ ​Koenig A, Heßmann E, Hanheide S, Gaedcke J, Zhang J, Billadeau DD, et al. ​mTOR Controls an Epigenetic Program Leading to Autophagy and Cell Growth Control​. ​ 13th Annual ENETS Conference for the Diagnosis and Treatment of Neuroendocrine Tumor Disease; ​Barcelona, SPAIN. ​Neuroendocrinology. ​2016;​103​
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  • 2016 Journal Article
    ​ ​Schirmer M, Mergler C, Droege L, Guhlich M, Gaedcke J, Ghadimi M, et al. ​EP-2057: Radiotoxicity prediction by gene expression profiling when simulating therapy in matched fibroblasts​. ​​Radiotherapy and Oncology. ​2016;​119​:​​S970​-S971​. ​doi:10.1016/S0167-8140(16)33308-4. 
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  • 2016 Journal Article
    ​ ​Azizian A, Gruber J, Ghadimi M, Gaedcke J. ​MicroRNA in rectal cancer​. ​​World Journal of Gastrointestinal Oncology. ​2016;​8​(5):​​416​. ​doi:10.4251/wjgo.v8.i5.416. 
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  • 2016 Conference Abstract
    ​ ​Jo P, Gusky L, Nietert MM, Kitz J, Conradi, Lena-Christin, Müller-Dornieden A, et al. ​Neoadjuvant therapy in rectal cancer - challenges of biobanking tumor biopsies taken prior to treatment​. ​​Oncology Research and Treatment. ​2016;​39​
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  • 2016 Journal Article
    ​ ​Wang J, Yang S, He P, Schetter AJ, Gaedcke J, Ghadimi BM, et al. ​Endothelial Nitric Oxide Synthase Traffic Inducer (NOSTRIN) is a Negative Regulator of Disease Aggressiveness in Pancreatic Cancer​. ​​Clinical Cancer Research. ​2016;​22​(24):​​5992​-6001​. ​doi:10.1158/1078-0432.CCR-16-0511. 
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  • 2016 Journal Article
    ​ ​Lueddecke S, Ertych N, Stenzinger A, Weichert W, Beißbarth T, Dyczkowski J, et al. ​The putative oncogene CEP72 inhibits the mitotic function of BRCA1 and induces chromosomal instability​. ​​Oncogene. ​2016;​35​(18):​​2398​-2406​. ​doi:10.1038/onc.2015.290. 
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  • 2016 Journal Article | 
    ​ ​Jo P, Nietert MM, Gusky L, Kitz J, Conradi, Lena-Christin, Müller-Dornieden A, et al. ​Neoadjuvant Therapy in Rectal Cancer - Biobanking of Preoperative Tumor Biopsies​. ​​Scientific Reports. ​2016;​6​. ​doi:10.1038/srep35589. 
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  • 2015 Journal Article | 
    ​ ​Srinivas US, Dyczkowski J, Beißbarth T, Gaedcke J, Mansour WY, Borgmann K, et al. ​5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair.​. ​​Oncotarget. ​2015;​6​(14):​​12574​-12586​. ​doi:10.18632/oncotarget.3728. 
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  • 2015 Journal Article | 
    ​ ​Wu Y, Lee, Suk-Hee, Williamson EA, Reinert BL, Cho JH, Xia F, et al. ​EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair​. ​​PLoS Genetics. ​2015;​11​(12). ​doi:10.1371/journal.pgen.1005675. 
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  • 2015 Journal Article
    ​ ​Singh SK, Chen, Nai-Ming, Heßmann E, Siveke JT, Lahmann M, Singh G, et al. ​Antithetical NFATc1-Sox2 and p53-miR200 signaling networks govern pancreatic cancer cell plasticity​. ​​The EMBO Journal. ​2015;​34​(4):​​517​-530​. ​doi:10.15252/embj.201489574. 
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  • 2015 Journal Article
    ​ ​Zhang X, Schulz R, Edmunds S, Krueger E, Markert E, Gaedcke J, et al. ​MicroRNA-101 Suppresses Tumor Cell Proliferation by Acting as an Endogenous Proteasome Inhibitor via Targeting the Proteasome Assembly Factor POMP​. ​​Molecular Cell. ​2015;​59​(2):​​243​-257​. ​doi:10.1016/j.molcel.2015.05.036. 
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  • 2015 Journal Article
    ​ ​Azizian A, Kramer F, Jo P, Wolff HA, Beißbarth T, Skarupke R, et al. ​Preoperative Prediction of Lymph Node Status by Circulating Mir-18b and Mir-20a During Chemoradiotherapy in Patients with Rectal Cancer​. ​​World Journal of Surgery. ​2015;​39​(9):​​2329​-2335​. ​doi:10.1007/s00268-015-3083-8. 
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  • 2014 Conference Abstract
    ​ ​Spitzner M, Roesler B, Bielfeld C, Herzberg C, Emons G, Gaedcke J, et al. ​Targeting STAT3 in vitro and in vivo reveals a novel therapeutic strategy to sensitize colorectal cancer cells to chemoradiotherapy​. ​ 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR); ​San Diego, CA. ​Cancer Research. ​2014;​74​(19)doi:10.1158/1538-7445.AM2014-855.
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  • 2014 Conference Abstract
    ​ ​Grade M, Spitzner M, Roesler B, Bielfeld C, Gaedcke J, Wolff HA, et al. ​Targeting STAT3 as a therapeutic strategy to sensitize colorectal cancer to chemoradiotherapy​. ​​Oncology Research and Treatment. ​2014;​37​
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  • 2014 Conference Abstract
    ​ ​Emons G, Spitzner M, Reineke S, Möller J, Kendziorra E, Beißbarth T, et al. ​Wnt/beta-catenin signaling mediates resistance of colorectal cancer cells to chemoradiotherapy​. ​​San Diego, CA. ​Cancer Research. ​2014;​74​(19)doi:10.1158/1538-7445.AM2014-3946.
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  • 2014 Journal Article | 
    ​ ​Landmann H, Proia DA, He S, Ogden FL, Kramer, Franz-Josef, Beißbarth T, et al. ​UDP glucuronosyltransferase 1A expression levels determine the response of colorectal cancer cells to the heat shock protein 90 inhibitor ganetespib​. ​​Cell Death and Disease. ​2014;​5​. ​doi:10.1038/cddis.2014.378. 
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  • 2014 Journal Article
    ​ ​Spitzner M, Roesler B, Bielfeld C, Emons G, Gaedcke J, Wolff HA, et al. ​STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo​. ​​International Journal of Cancer. ​2014;​134​(4):​​997​-1007​. ​doi:10.1002/ijc.28429. 
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  • 2013 Conference Abstract
    ​ ​Sprenger T, Gaedcke J, Conradi, Lena-Christin, Jo P, Jung K, Beißbarth T, et al. ​Association of CD133 expression levels with the k-ras mutation status in rectal cancers before and after preoperative radiochemotherapy​. ​ Gastrointestinal Cancers Symposium of the American-Society-of-Clinical-Oncology (ASCO); ​San Francisco, CA. ​Journal of Clinical Oncology. ​2013;​31​(4)
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  • 2013 Journal Article
    ​ ​Beck J, Bierau S, Balzer S, Andag R, Kanzow P, Schmitz J, et al. ​Digital droplet PCR for rapid quantification of donor DNA in the circulation of transplant recipients as a potential universal biomarker of graft injury​. ​​Clinical Chemistry. ​2013;​59​(12):​​1732​-1741​. ​doi:10.1373/clinchem.2013.210328. 
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  • 2013 Conference Paper
    ​ ​Salendo J, Spitzner M, Kramer F, Zhang X, Jo P, Wolff HA, et al. ​Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a,-224,-132 and let7g​. ​ 13th International Wolfsberg Meeting on Molecular Radiation Biology/Oncology; ​Ermatingen, SWITZERLAND. ​Radiotherapy and Oncology. ​2013;​108​(3):451​-457​. ​doi:10.1016/j.radonc.2013.06.032.
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  • 2013 Journal Article
    ​ ​Conradi, Lena-Christin, Styczen H, Sprenger T, Wolff HA, Roedel C, Nietert MM, et al. ​Frequency of HER-2 Positivity in Rectal Cancer and Prognosis​. ​​American Journal of Surgical Pathology. ​2013;​37​(4):​​522​-531​. ​doi:10.1097/PAS.0b013e318272ff4d. 
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  • 2012 Conference Abstract
    ​ ​Spitzner M, Roesler B, Bielfeld C, Gaedcke J, Rave-Fränk M, Beißbarth T, et al. ​Stat3 is a potential molecular target for chemoradiosensitization of colorectal cancer cells​. ​​Cancer Research. ​2012;​72​doi:10.1158/1538-7445.AM2012-3446.
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  • 2012 Conference Abstract
    ​ ​Grade M, Eimer C, Emons G, Kendziorra E, Spitzner M, Gaedcke J, et al. ​The Wnt transcription factor TCF4 mediates resistance of colorectal cancer cells to (chemo-) radiotherapy in a beta-catenin independent manner​. ​​Cancer Research. ​2012;​72​doi:10.1158/1538-7445.AM2012-5729.
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  • 2012 Journal Article
    ​ ​Gaedcke J, Grade M, Camps J, Sokilde R, Kaczkowski B, Schetter AJ, et al. ​The Rectal Cancer microRNAome - microRNA Expression in Rectal Cancer and Matched Normal Mucosa​. ​​Clinical Cancer Research. ​2012;​18​(18):​​4919​-4930​. ​doi:10.1158/1078-0432.CCR-12-0016. 
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  • 2012 Journal Article
    ​ ​Schirmer MA, Mergler CPN, Rave-Fränk M, Herrmann MKA, Hennies S, Gaedcke J, et al. ​Acute Toxicity of Radiochemotherapy in Rectal Cancer Patients: A Risk Particularly for Carriers of the TGFB1 Pro25 variant​. ​​International Journal of Radiation Oncology*Biology*Physics. ​2012;​83​(1):​​149​-157​. ​doi:10.1016/j.ijrobp.2011.05.063. 
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  • 2012 Journal Article
    ​ ​Jo P, Jung K, Grade M, Conradi, Lena-Christin, Wolff HA, Kitz J, et al. ​CpG island methylator phenotype infers a poor disease-free survival in locally advanced rectal cancer​. ​​Surgery. ​2012;​151​(4):​​564​-570​. ​doi:10.1016/j.surg.2011.08.013. 
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  • 2011 Conference Abstract
    ​ ​Kendziorra E, Ahlborn K, Spitzner M, Rave-Fränk M, Gaedcke J, Emons G, et al. ​Silencing of TCF7L2 sensitizes Wnt/beta-catenin signaling-dependent colorectal cancer cells to radiation​. ​​Cancer Research. ​2011;​71​doi:10.1158/1538-7445.AM2011-2490.
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  • 2011 Conference Abstract
    ​ ​Grade M, Spitzner M, Emons G, Kramer F, Gaedcke J, Rave-Fränk M, et al. ​Identification of potential relevant pathways and genes for resistance to chemoradiotherapy in colorectal cancer cells​. ​​Cancer Research. ​2011;​71​doi:10.1158/1538-7445.AM2011-2508.
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  • 2011 Conference Abstract
    ​ ​Christiansen H, Schirmer MA, Mergler CPN, Rave-Fränk M, Hennies S, Gaedcke J, et al. ​TGFB1 Pro25 allele as a risk marker for higher-grade acute Organ toxicity (CTC >= Grad2) during neoadjuvant Chemoradiotherapy in patients with locally advanced Rectal cancer (UICC Stage II/III)​. ​​Wiesbaden, GERMANY. ​Strahlentherapie und Onkologie. ​2011;​187​
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  • 2011 Journal Article
    ​ ​Kendziorra E, Ahlborn K, Spitzner M, Rave-Fränk M, Emons G, Gaedcke J, et al. ​Silencing of the Wnt transcription factor TCF4 sensitizes colorectal cancer cells to (chemo-) radiotherapy​. ​​Carcinogenesis. ​2011;​32​(12):​​1824​-1831​. ​doi:10.1093/carcin/bgr222. 
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  • 2011 Journal Article
    ​ ​Grade M, Hummon AB, Camps J, Emons G, Spitzner M, Gaedcke J, et al. ​A genomic strategy for the functional validation of colorectal cancer genes identifies potential therapeutic targets​. ​​International Journal of Cancer. ​2011;​128​(5):​​1069​-1079​. ​doi:10.1002/ijc.25453. 
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  • 2010 Conference Abstract
    ​ ​Grade M, Hummon AB, Camps J, Emons G, Spitzner M, Gaedcke J, et al. ​A COMBINED FUNCTIONAL AND SYSTEMS BIOLOGY APPROACH IDENTIFIES COLORECTAL CANCER GENES AS NOVEL POTENTIAL THERAPEUTIC TARGETS​. ​ Congress of the International-Society-for-Cellular-Oncology; ​Dresden, GERMANY. ​Cellular Oncology. ​2010;​32​(3):164​-165​. ​
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  • 2010 Conference Abstract
    ​ ​Gaedcke J, Grade M, Jung K, Camps J, Jo P, Becker H, et al. ​The effect of KRAS mutations on the rectal cancer transcriptome: clinical implications​. ​ 22nd EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics; ​Berlin, GERMANY. ​EJC SUPPLEMENTS. ​2010;​8​(7)doi:10.1016/S1359-6349(10)71892-9.
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  • 2010 Conference Abstract
    ​ ​Kendziorra E, Spitzner M, Emons G, Ahlborn K, Gaedcke J, Rave-Fränk M, et al. ​RNAi-MEDIATED SILENCING OF TCF7L2 SENSITIZES COLORECTAL CANCER CELLS TO RADIATION​. ​ Congress of the International-Society-for-Cellular-Oncology; ​Dresden, GERMANY. ​Cellular Oncology. ​2010;​32​(3):229​-230​. ​
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  • 2010 Journal Article
    ​ ​Gaedcke J, Grade M, Jung K, Camps J, Jo P, Emons G, et al. ​Mutated KRAS Results in Overexpression of DUSP4, a MAP-Kinase Phosphatase, and SMYD3, a Histone Methyltransferase, in Rectal Carcinomas​. ​​Genes Chromosomes and Cancer. ​2010;​49​(11):​​1024​-1034​. ​doi:10.1002/gcc.20811. 
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  • 2010 Journal Article
    ​ ​Gaedcke J, Grade M, Jung K, Schirmer MA, Jo P, Obermeyer C, et al. ​KRAS and BRAF mutations in patients with rectal cancer treated with preoperative chemoradiotherapy​. ​​Radiotherapy and Oncology. ​2010;​94​(1):​​76​-81​. ​doi:10.1016/j.radonc.2009.10.001. 
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  • 2010 Journal Article | 
    ​ ​Spitzner M, Emons G, Kramer F, Gaedcke J, Rave-Fränk M, Scharf, Jens-Gerd, et al. ​A GENE EXPRESSION SIGNATURE FOR CHEMORADIOSENSITIVITY OF COLORECTAL CANCER CELLS​. ​​International Journal of Radiation Oncology*Biology*Physics. ​2010;​78​(4):​​1184​-1192​. ​doi:10.1016/j.ijrobp.2010.06.023. 
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  • 2010 Journal Article | 
    ​ ​Opitz L, Salinas-Riester G, Grade M, Jung K, Jo P, Emons G, et al. ​Impact of RNA degradation on gene expression profiling​. ​​BMC Medical Genomics. ​2010;​3​. ​doi:10.1186/1755-8794-3-36. 
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  • 2010 Journal Article
    ​ ​Jung K, Grade M, Gaedcke J, Jo P, Opitz L, Becker H, et al. ​A new sensitivity-preferred strategy to build prediction rules for therapy response of cancer patients using gene expression data​. ​​Computer Methods and Programs in Biomedicine. ​2010;​100​(2):​​132​-139​. ​doi:10.1016/j.cmpb.2010.03.016. 
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  • 2009 Conference Abstract
    ​ ​Wolff HA, Gaedcke J, Jung K, Hermann RM, Rothe H, Herrmann MK, et al. ​High grade acute toxicity during neo adjuvant radiochemotherapy as positive predictor in histopathological tumour regression in locally advanced rectum carcinoma (UICC II/III)​. ​ 15th Annual Conference of the Deutschen-Gesellschaft-fur-Radioonkologie; ​Bremen, GERMANY. ​Strahlentherapie und Onkologie. ​2009;​185​
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