Dr. Thomas Prukop

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unigoe
 

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  • 2020 | Journal Article
    ​ ​Prukop T, Wernick S, Boussicault L, Ewers D, Jäger K, Adam J, et al. ​Synergistic PXT3003 therapy uncouples neuromuscular function from dysmyelination in male Charcot–Marie–Tooth disease type 1A (CMT1A) rats​. ​​Journal of Neuroscience Research. ​2020;​98​(10):​​1933​-1952​. ​doi:10.1002/jnr.24679. 
    ​Details  DOI 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Rafehi M, Faltraco F, Matthaei J, Prukop T, Jensen O, Grytzmann A, et al. ​Highly Variable Pharmacokinetics of Tyramine in Humans and Polymorphisms in OCT1, CYP2D6, and MAO-A​. ​​Frontiers in Pharmacology. ​2019;​10​:​​1297​. ​doi:10.3389/fphar.2019.01297. 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article
    ​ ​Matthaei J, Seitz T, Jensen O, Tann A, Prukop T, Tadjerpisheh S, et al. ​OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil​. ​​Clinical Pharmacology and Therapeutics. ​2019;​105​(1):​​190​-200​. ​doi:10.1002/cpt.1128. 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | 
    ​ ​Fledrich R, Abdelaal T, Rasch L, Bansal V, Schütza V, Brügger B, et al. ​Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy​. ​​Nature Communications. ​2018;​9​(1). ​doi:10.1038/s41467-018-05420-0. 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Tzvetkov MV, Matthaei J, Pojar S, Faltraco F, Vogler S, Prukop T, et al. ​Increased Systemic Exposure and Stronger Cardiovascular and Metabolic Adverse Reactions to Fenoterol in Individuals with Heritable OCT1 Deficiency​. ​​Clinical Pharmacology & Therapeutics. ​2017;​103​(5):​​868​-878​. ​doi:10.1002/cpt.812. 
    ​Details  DOI 
  • 2014 | Journal Article
    ​ ​Fledrich R, Stassart RM, Klink A, Rasch LM, Prukop T, Haag L, et al. ​Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A​. ​​Nature Medicine. ​2014;​20​(9):​​1055​-1061​. ​doi:10.1038/nm.3664. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2007 | Journal Article
    ​ ​Meyer zu Hörste G, Prukop T, Liebetanz D, Möbius W, Nave, Klaus-Armin, Sereda MW. ​Antiprogesterone therapy uncouples axonal loss from demyelination in a transgenic rat model of CMT1A neuropathy​. ​​Annals of Neurology. ​2007;​61​(1):​​61​-72​. ​doi:10.1002/ana.21026. 
    ​Details  DOI  WoS 

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