Myelin replacement triggered by single-cell demyelination in mouse cortex
2020 | journal article; research paper
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- Authors
- Snaidero, Nicolas; Schifferer, Martina ; Mezydlo, Aleksandra; Zalc, Bernard; Kerschensteiner, Martin ; Misgeld, Thomas
- Abstract
- Myelin, rather than being a static insulator of axons, is emerging as an active participant in circuit plasticity. This requires precise regulation of oligodendrocyte numbers and myelination patterns. Here, by devising a laser ablation approach of single oligodendrocytes, followed by in vivo imaging and correlated ultrastructural reconstructions, we report that in mouse cortex demyelination as subtle as the loss of a single oligodendrocyte can trigger robust cell replacement and remyelination timed by myelin breakdown. This results in reliable reestablishment of the original myelin pattern along continuously myelinated axons, while in parallel, patchy isolated internodes emerge on previously unmyelinated axons. Therefore, in mammalian cortex, internodes along partially myelinated cortical axons are typically not reestablished, suggesting that the cues that guide patchy myelination are not preserved through cycles of de- and remyelination. In contrast, myelin sheaths forming continuous patterns show remarkable homeostatic resilience and remyelinate with single axon precision.
- Issue Date
- 2020
- Journal
- Nature Communications
- Project
- TRR 274: Checkpoints of Central Nervous System Recovery
TRR 274 | B02: Inflammatory neurodegeneration and repair mechanisms in childhood onset autoimmune and neurometabolic demyelinating CNS disease
TRR 274 | C02: In vivo detection and targeting of calcium clearance and axonal membrane repair after acute CNS insults
TRR 274 | C05: Checkpoints for circuit integration of nascent neurons in the injured brain
TRR 274 | Z01: Bioimaging Platform - Working Group
- RG Kerschensteiner (Neuroimmune Interactions)
RG Misgeld
RG Schifferer - ISSN
- 2041-1723
- Language
- English