Selective plasticity of callosal neurons in the adult contralesional cortex following murine traumatic brain injury
2022 | journal article; research paper
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Cite this publication
Empl, Laura, Alexandra Chovsepian, Maryam Chahin, Wing Yin Vanessa Kan, Julie Fourneau, Valérie Van Steenbergen, Sanofer Weidinger et al. "Selective plasticity of callosal neurons in the adult contralesional cortex following murine traumatic brain injury." Nature Communications 13, no. 1 (2022): 2659. https://doi.org/10.1038/s41467-022-29992-0.
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Details
- Authors
- Empl, Laura; Chovsepian, Alexandra; Chahin, Maryam; Kan, Wing Yin Vanessa; Fourneau, Julie; Van Steenbergen, Valérie; Weidinger, Sanofer; Marcantoni, Maite; Ghanem, Alexander; Bradley, Peter; Conzelmann, Karl Klaus; Cai, Ruiyao; Ghasemigharagoz, Alireza; Ertürk, Ali; Wagner, Ingrid; Kreutzfeldt, Mario; Merkler, Doron; Liebscher, Sabine; Bareyre, Florence M.
- Abstract
- Traumatic brain injury (TBI) results in deficits that are often followed by recovery. The contralesional cortex can contribute to this process but how distinct contralesional neurons and circuits respond to injury remains to be determined. To unravel adaptations in the contralesional cortex, we used chronic in vivo two-photon imaging. We observed a general decrease in spine density with concomitant changes in spine dynamics over time. With retrograde co-labeling techniques, we showed that callosal neurons are uniquely affected by and responsive to TBI. To elucidate circuit connectivity, we used monosynaptic rabies tracing, clearing techniques and histology. We demonstrate that contralesional callosal neurons adapt their input circuitry by strengthening ipsilateral connections from pre-connected areas. Finally, functional in vivo two-photon imaging demonstrates that the restoration of pre-synaptic circuitry parallels the restoration of callosal activity patterns. Taken together our study thus delineates how callosal neurons structurally and functionally adapt following a contralateral murine TBI.
- Issue Date
- 2022
- Journal
- Nature Communications
- Project
- TRR 274: Checkpoints of Central Nervous System Recovery
TRR 274 | C03: Glial sculpting of neuronal remodeling as a checkpoint of recovery in the injured CNS - Working Group
- RG Bareyre (Neuronal Repair)
- ISSN
- 2041-1723
- Language
- English