Activation of caspase-3 in axotomized rat retinal ganglion cells in vivo
1999 | journal article; research paper. A publication with affiliation to the University of Göttingen.
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Kermer, Pawel, N. Klocker, M. Labes, S Thomsen, A. Srinivasan, and Mathias Bähr. "Activation of caspase-3 in axotomized rat retinal ganglion cells in vivo." FEBS Letters 453, no. 3 (1999): 361-364. https://doi.org/10.1016/S0014-5793(99)00747-4.
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- Authors
- Kermer, Pawel ; Klocker, N.; Labes, M.; Thomsen, S; Srinivasan, A.; Bähr, Mathias
- Abstract
- Recently, we have shown that inhibition of caspase-3-like caspases is the most effective treatment strategy to protect adult rat retinal ganglion cells from secondary death following optic nerve transection. In the present study, we localized active caspase-3 in axotomized retinal ganglion cells in vivo and demonstrated a co-localization of the active p20 fragment and TUNEL-staining in some of these cells. In line with this, we detected an enhanced cleavage and activity of caspase-3 protein in retinal tissue after lesion, while caspase-3 mRNA expression remained unchanged. These data suggest caspase-3 as an important mediator of secondary retinal ganglion cell death following axotomy in vivo. (C) 1999 Federation of European Biochemical Societies.
- Issue Date
- 1999
- Publisher
- Elsevier Science Bv
- Journal
- FEBS Letters
- ISSN
- 0014-5793